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anti-Human CDKL5 Antibodies:
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Human Polyclonal CDKL5 Primary Antibody for WB - ABIN611314
Barbara, Wrana, Letarte: Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. in The Journal of biological chemistry 1999
Show all 4 Pubmed References
Human Polyclonal CDKL5 Primary Antibody for ICC, IF - ABIN4297085
Ricciardi, Ungaro, Hambrock, Rademacher, Stefanelli, Brambilla, Sessa, Magagnotti, Bachi, Giarda, Verpelli, Kilstrup-Nielsen, Sala, Kalscheuer, Broccoli: CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons. in Nature cell biology 2012
Although abilities were markedly impaired for the majority with the CDKL5 disorder, some females and a few males had better functional abilities. This variability may be related to underlying gene variants, with females with a late truncating variant having better levels of ability than those with no functional protein.
We have characterised the predominant brain isoform of CDKL5, a 9.7 kb transcript comprised of 18 exons with a large 6.6 kb 3'-untranslated region (UTR (show UTS2R Antibodies)), which we name hCDKL5_1. In addition we describe new exonic regions and a range of novel splice and UTR (show UTS2R Antibodies) isoforms
In the asymptomatic mother, the mutated copy of the CDKL5 gene was inactivated in 90% of blood cells. We also identified a premature stop codon (p.Arg926*) in IQSEC2 (show IQSEC2 Antibodies) in a patient with a Rett-like phenotype. Finally, exome sequencing enabled us to characterize a heterozygous de novo missense (p.Val408Ala) in KCNA2 (show KCNA2 Antibodies) in a girl with infantile-onset seizures variant of Rett syndrome (RTT)
The results suggested the mutant CDKL5 was responsible for the Rett syndrome disease.
Rett syndrome with early epilepsy and the congenital variant are mainly due to variations in the CDKL5 and FOXG1 (show FOXG1 Antibodies) genes, respectively
Mutations in exon 8 of cyclin-dependent kinase-like 5 gene (show GPD1 Antibodies) were determined to be disease-causing in epileptic encephalopathy.
study presents the genotype of 2 sisters, a CDKL5 mutation c. 283-3_290del, but different phenotype
Data suggest that the increased dosage of cyclin dependent kinase like 5 protein(CDKL5) might have affected interactions of this kinase with its substrates, leading to perturbation of neurodevelopmental and neurobehavioral abnormalities.
It was indicated that CDKL5 controls excitatory synaptic transmission and the conditions associated with CDKL5 deviation in man indicates synaptic abnormalities.
CDKL5 gene mutations accounted for 5.4% of boys with early onset epileptic encephalopathy
The data of this study demonstrate that dendritic spine stabilization is strongly regulated by CDKL5.
Our findings demonstrate that CDKL5 is an important regulator of synaptic function in glutamatergic neurons and serves a critical role in learning and memory.
Nuclear HDAC4 (show HDAC5 Antibodies) binds to chromatin as well as to MEF2A (show MEF2A Antibodies) transcription factor, leading to histone deacetylation and altered neuronal gene expression. By using a Cdkl5 knockout (Cdkl5 -/Y) mouse model, we found that hypophosphorylated HDAC4 (show HDAC5 Antibodies) translocates to the nucleus of neural precursor cells, thereby reducing histone 3 acetylation.
Taken together, these results strongly suggested that DYRK1A (show DYRK1A Antibodies) bound to CDKL5 and phosphorylated it on Ser (show SIGLEC1 Antibodies)-308, thus interfering with its nuclear localization.
CDKL5 deletion during development more markedly impairs the establishment of a correct GABAergic cerebellar network than that of glutamatergic one, leading to the behavioural symptoms associated with CDKL5 mutation.
these results point to a role of CDKL5 in the early steps of neuronal differentiation that can be explained, at least in part, by its association with shootin1 (show KIAA1598 Antibodies).
Findings highlight a critical role of CDKL5 in the fundamental processes of brain development, namely neuronal precursor proliferation, survival and maturation
Amph1 (show AMPH Antibodies) is the cytoplasmic substrate for CDKL5.
CDKL5 regulates signal transduction pathways and mediates autistic-like phenotypes.
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.
cyclin-dependent kinase-like 5
, cyclin-dependent kinase-like 5-like
, cyclin dependent kinase 5 transcript
, serine/threonine kinase 9
, serine/threonine-protein kinase 9