CDKL5 antibody (C-Term)

Catalog No. ABIN391362

The Rabbit Polyclonal anti-CDKL5 antibody (Clone RB3556) (ABIN391362) specifically detects CDKL5 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CDKL5 antibody (C-Term) (ABIN391362)

Target: CDKL5 (Cyclin-Dependent Kinase-Like 5 (CDKL5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKL5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3556

Product Details anti-CDKL5 Antibody

Binding Specificity: AA 982-1012, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CDKL5 (STK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 982-1012 amino acids from the C-terminal region of human CDKL5 (STK9).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for CDKL5

Target: CDKL5 (Cyclin-Dependent Kinase-Like 5 (CDKL5))

Alternative Name: CDKL5 (STK9)

Background: Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.

Molecular Weight: 107519

Gene ID: 6792

NCBI Accession: NP_001032420, NP_003150

UniProt: O76039

Pathways: Regulation of Cell Size