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Browse our CXCR4 Proteins (CXCR4)

Full name:
Chemokine (C-X-C Motif) Receptor 4 Proteins (CXCR4)
On www.antibodies-online.com are 17 Chemokine (C-X-C Motif) Receptor 4 (CXCR4) Proteins from 7 different suppliers available. Additionally we are shipping CXCR4 Antibodies (469) and CXCR4 Kits (32) and many more products for this protein. A total of 534 CXCR4 products are currently listed.
Synonyms:
cb403, CD184, Cmkar4, CXC-R4, CXC-R4-B, CXCR-4, CXCR-4-B, CXCR4, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, PB-CKR, PBSF/SDF-1, Sdf1r, WHIM, xcxcr4, zgc:109863
list all proteins Gene Name GeneID UniProt
CXCR4 12767 P70658
CXCR4 60628  
CXCR4 7852 P61073

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CXCR4 Proteins (CXCR4) by Origin

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Top referenced CXCR4 Proteins

  1. Human CXCR4 Protein expressed in Escherichia coli (E. coli) - ABIN2180954 : Saini, Marchese, Majetschak: CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin. in The Journal of biological chemistry 2010 (PubMed)

More Proteins for CXCR4 Interaction Partners

Medaka Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. bilateral lineup in the trunk before PGC (show PGC Proteins) migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor (show CCR1 Proteins) gene cxcr4b

Mouse (Murine) Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. Irradiation enhances expression of cxcr4 in glioma cells via a HIF-1alpha (show HIF1A Proteins)-independent pathway.

  2. CXCL12 (show CXCL12 Proteins)/CXCR4 regulates HA and LG following corneal suture placement, and provides a novel strategy to inhibit LG. Notably, the present study is the first to demonstrate evidence that CXCL12 (show CXCL12 Proteins)/CXCR4 modulates LG in a corneal suture-induced mouse model.

  3. CXCR4 expression was significantly associated with higher rate of metastasis and poor prognosis in patients with bone and soft tissue sarcoma. (Meta-analysis)

  4. the present study indicates that the CXCL12 (show CXCL12 Proteins)/CXCR4 signaling pathway is important during the development of cochleae in neonatal mice.

  5. crosstalk between astrocytic CXCL12 (show CXCL12 Proteins) and microglial CXCR4 in the pathogenesis of neuropathic pain.

  6. Results from using a plasmid transient expression of shRNA antiCXR4 shown that CXCR4 plays a critical role in the initial stages of development of murine melanoma B16F10 melanoma.

  7. DPP-4 (show DPP4 Proteins) inhibition may have direct protective effects on the post-myocardial infarction heart by inducing an antiapoptotic effect and inhibiting a decrease in vessel number through the SDF-1a/CXCR4-mediated STAT3 (show STAT3 Proteins) signaling pathway.

  8. confirm a pivotal role of the SDF-1/CXCR4/CXCR7 axis for chronic allograft vasculopathy development

  9. CXCR4 has an important role in endothelial progenitor cells migration at the ischemic site.

  10. CXCR4/CXCL12 (show CXCL12 Proteins) signaling may control movement of epithelial progenitors from the dental stem cell niche.

Human Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. these results suggest that the CD133/CXCR4/epithelial-mesenchymal transition axis may be a prognostic marker and may provide novel targets for combinational therapies in the treatment of non-small cell lung cancer

  2. Implication of peptide carriers modified with CXCR4 ligand is a promising approach to develop targeted siRNA delivery system.

  3. High CXCR4 expression is associated with cisplatin-resistance in non-small cell lung cancer.

  4. Chronic prostatitis/chronic pelvic pain syndrome has negative effects on surrogate parameters of male fertility and is associated significantly with systemic and local epigenetic inactivation of CXCR4

  5. our results demonstrate for the first time that PA is a novel inhibitor of HER2 (show ERBB2 Proteins) and CXCR4 expression via kinase pathways and may play a critical role in determining the metastatic potential of breast cancer cells

  6. miR (show MLXIP Proteins)-126 was downregulated in thyroid cancer. In addition, miR (show MLXIP Proteins)-126 was revealed to inhibit thyroid cancer cell proliferation, migration and invasion by targeting CXCR4.

  7. Our results suggest that the bach1 (show BACH1 Proteins)-specific small interfering RNA effectively decrease CXCR4 receptor, matrix metalloproteinase-9 (show MMP9 Proteins) expression and breast adenocarcinoma cells invasive, also increased the expression of tumor-suppressive microRNA-203 and miR (show MLXIP Proteins)-145

  8. the SDF1 (show CXCL12 Proteins)/CXCR4 axis promoted cell apoptosis in human degenerative NPCs via the NFkappaB (show NFKB1 Proteins) pathway, thus suggesting that SDF1 (show CXCL12 Proteins)/CXCR signaling may be a therapeutic target for the treatment of degenerative IVD (show IVD Proteins) diseases.

  9. mass spectrum followed by immunoprecipitation identified non-muscle myosin heavy chain-IIA (NMMHC-IIA (show MYH9 Proteins)) as the CXCR4-interacting protein. Furthermore, pharmaceutical inhibition of NMMHC-IIA (show MYH9 Proteins) by blebbistatin dampened the nuclear translocation of CXCR4 as well as the metastatic capacity of RCC (show XRCC1 Proteins) cells

  10. CXCL12 (show CXCL12 Proteins) may be an effective diagnostic marker for papillary thyroid carcinoma, and CXCL12 (show CXCL12 Proteins)/CXCR4/CXCR7 axis may contribute to thyroid cancer development by regulating cancer cell migration and invasion via AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins) signaling and MMP-2 (show MMP2 Proteins) activation.

Pig (Porcine) Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. CXCR4 controls leukocyte mobilization after trauma.

  2. The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (show CXCL12 Proteins)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.

  3. reports transmural and perivascular expression patterns of chemokines CCL2 (show CCL2 Proteins) and CXCL2 (show CXCL2 Proteins) and of chemokine (show CCL1 Proteins) receptors CCR2 (show CCR2 Proteins), CCR5, and CXCR4 following coronary angioplasty

Xenopus laevis Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

Cow (Bovine) Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. There is a potential link between follicular SDF1 (show CXCL12 Proteins)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.

  2. The combination of low expression of CXCR4 and high expression of IL-10 (show IL10 Proteins) might be closely concerned with some bias for the production of PI calves.

Rhesus Monkey Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. The increased CXCR4 and CXCR7 expression resulted in increased SDF-1 (show CXCL12 Proteins)-induced RF/6A cell migration and tube formation.

  2. The CXCR7/CXCR4/CXCL12 (show CXCL12 Proteins) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.

  3. These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4, and TGFB1 (show TGFB1 Proteins) expression and inhibiting choroidl endothelial cell proliferation.

  4. Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively

Zebrafish Chemokine (C-X-C Motif) Receptor 4 (CXCR4) interaction partners

  1. Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.

  2. SDF1a directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7.

  3. Hoxb8a is induced by and cooperates with Wnt (show WNT2 Proteins) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.

  4. Expression of Cxcr4 and Cxcl12 (show CXCL12 Proteins) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (show CXCL12 Proteins)/Cxcr4 pair in brain development and functioning.

  5. show that inactivation of the estrogen receptor ESR1 (show ESR1 Proteins) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (show ESR1 Proteins) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.

  6. Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.

  7. A CXCR4-like chemokine receptor (show CCR1 Proteins) is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (show CXCL12 Proteins)-CXCR4 system.

  8. Knocking down CXCR4 results in severe defects in primordial germ cell migration.

  9. SDF-1 (show CXCL12 Proteins)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.

  10. chemokine (show CCL1 Proteins) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish

CXCR4 Protein Profile

Protein Summary

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with CXCR4

  • chemokine (C-X-C motif) receptor 4 (cxcr4)
  • chemokine (C-X-C motif) receptor 4 (CXCR4)
  • chemokine (C-X-C motif) receptor 4 (Cxcr4)
  • chemokine (C-X-C motif) receptor 4 (cxcr4-b)
  • chemokine (C-X-C motif), receptor 4b (cxcr4b)
  • neuropeptide Y receptor type 3 (CXCR4)
  • cb403 protein
  • CD184 protein
  • Cmkar4 protein
  • CXC-R4 protein
  • CXC-R4-B protein
  • CXCR-4 protein
  • CXCR-4-B protein
  • CXCR4 protein
  • D2S201E protein
  • FB22 protein
  • HM89 protein
  • HSY3RR protein
  • LAP3 protein
  • LCR1 protein
  • LESTR protein
  • NPY3R protein
  • NPYR protein
  • NPYRL protein
  • NPYY3R protein
  • PB-CKR protein
  • PBSF/SDF-1 protein
  • Sdf1r protein
  • WHIM protein
  • xcxcr4 protein
  • zgc:109863 protein

Protein level used designations for CXCR4

C-X-C chemokine receptor type 4 , SDF-1 receptor , Stromal cell-derived factor 1 receptor , chemokine (C-X-C motif) receptor 4 , CXC-R4 , CXCR-4 , chemokine (C-X-C) receptor 4 , chemokine receptor 4 , fusin , leukocyte-derived seven transmembrane domain receptor , leukocyte-expressed seven-transmembrane-domain , pre-B-cell-derived chemokine receptor , stromal cell-derived factor 1 receptor , CXC chemokine receptor , LESTR , chemokine receptor (LCR1) , CD184 antigen , leukocyte-derived seven-transmembrane-domain receptor , lipopolysaccharide-associated protein 3 , neuropeptide Y receptor Y3 , seven transmembrane helix receptor , seven-transmembrane-segment receptor, spleen , C-X-C chemokine receptor type 4-B , SDF-1 receptor B , SDF-1 receptor-B , Stromal cell-derived factor 1 receptor-B , stromal cell-derived factor 1 receptor B , LCR1 , chemokine receptor CXCR4 , CXC chemokine receptor 4 , ody , odysseus

GENE ID SPECIES
100038176 Xenopus (Silurana) tropicalis
100049444 Oryzias latipes
100346189 Oryctolagus cuniculus
100451032 Pongo abelii
100604120 Nomascus leucogenys
12767 Mus musculus
60628 Rattus norvegicus
7852 Homo sapiens
396659 Sus scrofa
380373 Xenopus laevis
281736 Bos taurus
493676 Felis catus
483900 Canis lupus familiaris
707329 Macaca mulatta
395324 Gallus gallus
100126711 Papio anubis
450130 Pan troglodytes
114447 Danio rerio
443532 Ovis aries
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