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bilateral lineup in the trunk before PGC migration colonizing gonadal areas is defective in PGCS expressing a missense mutation in chemokine receptor gene cxcr4b
Efficient plasma cell differentiation and trafficking require Cxcr4 desensitization.
High CXCR4 expression is associated with Prostate Cancer.
Data show that FLT3 ligand (FLT3L (show FLT3LG Proteins)) enhances thymopoiesis through increased survival and export of hematopoietic stem cell (Lin([minus])Sca1 (show ATXN1 Proteins)(+)c-Kit(+) [LSK (show LCK Proteins)] cells via CXCR4 receptor regulation.
Adipocytes promoted osteoclast differentiation, function and expression of adhesion-related molecules through the CXCL12 (show CXCL12 Proteins)/CXCR4 signalling pathway.
Efficient Cxcr4 desensitization is critical for lymphoid differentiation of hematopoietic stem and progenitor cell (HSPC (show PSMA7 Proteins)), and its impairment is a key mechanism underpinning the lymphopenia observed in mice and likely in WHIM Syndrome (WS) patients.
COUP-TFI (show NR2F1 Proteins) is required predominantly in Dentate gyrus progenitors for modulating expression of the Cxcr4 receptor during granule cell neurogenesis and migration.
CXCR4, CCR2 (show CCR2 Proteins), and CX3CR1 (show CX3CR1 Proteins) direct dendritic cell precursors from the bone marrow to the lung differentially.
data suggest that prolonged but reversible pharmacologic blockade of the CXCR4/CXCL12 axis represents an approach that releases HSPC with efficiency superior to any other known mobilization strategy and may also serve as an effective method to expand the BM HSPC pool.
role of MIM (show MTSS1 Proteins) in the homeostasis of BM cells, including HSPCs, through modulation of the CXCR4/SDF-1 (show CXCL12 Proteins) axis and interactions of BM leukocytes with their microenvironments.
Results suggest that SDF-1 (show CXCL12 Proteins)/CXCR4 signaling plays an important role in the dynamics associated with adult sub-ventricular zone lineage cell proliferation and differentiation.
Efficient plasma cell differentiation and trafficking require Cxcr4 desensitization which does not occur in the WHIM syndrome patients.
ligand-induced activation of the chemokine receptor CXCR4 and the urotensin 2 receptor UTS2R, triggers a marked reduction in the biogenesis of autophagosomes.
The data describe the critical early step of directional cell movement toward SDF-1 (show CXCL12 Proteins) that ZAP-70 (show ZAP70 Proteins) is recruited to the CXCR4 at the leading edge of membrane and consequently modulates lamellipodia/filopodia formation and integrin activation.
Data suggest that the interplay between CCR1 upregulation and inactivation of CXCR4 signaling (the CCR1/CXCR4 axis) drives the egress of multiple myeloma PCs from the bone marrow, leading to disease dissemination.
High CXCR4 expression is associated with gemcitabine resistance in pancreatic cancer.
Mutations in CXCR4 have been identified in approximately 29% of patients with WM having the MYD88L265P mutation. Patients with MYD88L265P and CXCR4 nonsense mutations are reported to show more extensive bone marrow involvement, higher serum IgM levels, and more pronounced hyperviscosity requiring therapeutic intervention.
High CXCR4 expression is associated with colon cancer metastasis.
our findings indicate the functional role of HBx in regulating the stem-like properties of OV6(+) CSCs in HCC (show FAM126A Proteins) through the MDM2 (show MDM2 Proteins)/CXCL12 (show CXCL12 Proteins)/CXCR4/beta-catenin (show CTNNB1 Proteins) signaling axis, and identify HBx, MDM2 (show MDM2 Proteins), CXCR4 and OV6 as a novel prognostic pathway and potential therapeutic targets for patients with HBV-related HCC (show FAM126A Proteins) patients
study revealed that the CXCL12 (show CXCL12 Proteins)-CXCR4 interaction is crucial for stromal cell contact-mediated early B lymphoid and pDC (show PNKD Proteins) differentiation from immature hematopoietic and early T lymphoid precursors with a multilineage differentiation potential but not for stromal cell contact-independent generation of early T lymphoid precursors.
Knocking-down CXCR4 in degenerated nucleus pulposus cells abolished the mesenchymal-stem-cell-induced decrease in the mechanical moduli and increased biological activity of degenerated NPCs, suggesting a crucial role for SDF-1 (show CXCL12 Proteins)/CXCR4 signaling.
CXCR4 controls leukocyte mobilization after trauma.
The new method has shown to be capable of promoting CSCs proliferation and differentiation into cardiomyocytes through activating the SDF-1 (show CXCL12 Proteins)/CXCR4 axis, while inhibiting myocardial apoptosis , thereby enhancing myocardial regeneration.
reports transmural and perivascular expression patterns of chemokines CCL2 (show CCL2 Proteins) and CXCL2 (show CXCL2 Proteins) and of chemokine (show CCL1 Proteins) receptors CCR2 (show CCR2 Proteins), CCR5, and CXCR4 following coronary angioplasty
The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2.
There is a potential link between follicular SDF1 (show CXCL12 Proteins)/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
The combination of low expression of CXCR4 and high expression of IL-10 (show IL10 Proteins) might be closely concerned with some bias for the production of PI calves.
The increased CXCR4 and CXCR7 (show CXCR7 Proteins) expression resulted in increased SDF-1 (show CXCL12 Proteins)-induced RF/6A cell migration and tube formation.
The CXCR7 (show CXCR7 Proteins)/CXCR4/CXCL12 (show CXCL12 Proteins) axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4, and TGFB1 (show TGFB1 Proteins) expression and inhibiting choroidl endothelial cell proliferation.
Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Arteries are formed by vein-derived endothelial tip cells, this process critically depends on chemokine receptor Cxcr4 function.
SDF1a (show CXCL12 Proteins) directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7 (show CXCR7 Proteins).
Hoxb8a is induced by and cooperates with Wnt (show WNT2 Proteins) signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.
Expression of Cxcr4 and Cxcl12 (show CXCL12 Proteins) in radial glial cells of the adult zebrafish brain supports important roles for the Cxcl12 (show CXCL12 Proteins)/Cxcr4 pair in brain development and functioning.
show that inactivation of the estrogen receptor ESR1 (show ESR1 Proteins) results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 (show ESR1 Proteins) overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Study suggest that the Cxcl12a-Cxcr4b ligand-receptor pair are involved in the migration of GnRH3 neurons in zebrafish, and are therefore crucial for the development of this system.
A CXCR4-like chemokine receptor is expressed by the migrating lateral line primordium cells. Both the formation and the innervation of this system depend on the SDF1 (show CXCL12 Proteins)-CXCR4 system.
Knocking down CXCR4 results in severe defects in primordial germ cell migration.
SDF-1 (show CXCL12 Proteins)/CXCR4 signaling is important for guiding retinal ganglion cell axons within the retina to the optic stalk to exit the retina.
chemokine (show CCL1 Proteins) signaling contributes to both the olfactory placode assembly and the olfactory sensory neurons axon pathfinding in zebrafish
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
C-X-C chemokine receptor type 4
, SDF-1 receptor
, Stromal cell-derived factor 1 receptor
, chemokine (C-X-C motif) receptor 4
, chemokine (C-X-C) receptor 4
, chemokine receptor 4
, leukocyte-derived seven transmembrane domain receptor
, leukocyte-expressed seven-transmembrane-domain
, pre-B-cell-derived chemokine receptor
, stromal cell-derived factor 1 receptor
, CXC chemokine receptor
, chemokine receptor (LCR1)
, CD184 antigen
, leukocyte-derived seven-transmembrane-domain receptor
, lipopolysaccharide-associated protein 3
, neuropeptide Y receptor Y3
, seven transmembrane helix receptor
, seven-transmembrane-segment receptor, spleen
, C-X-C chemokine receptor type 4-B
, SDF-1 receptor B
, SDF-1 receptor-B
, Stromal cell-derived factor 1 receptor-B
, stromal cell-derived factor 1 receptor B
, chemokine receptor CXCR4
, CXC chemokine receptor 4