Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
New function of p73 (show ARHGAP24 Proteins), independent of p53 (show TP53 Proteins), in the neurogenic architecture of the SVZ of rodent brain.
these results therefore highlight an unanticipated role for p53 (show TP53 Proteins) family proteins in a regulatory network that integrates essential Wnt (show WNT2 Proteins)-Tcf (show HNF4A Proteins) and nodal-Smad (show SMAD1 Proteins) inputs.
TAp73 as necessary and sufficient for basal body docking, axonemal extension, and motility during the differentiation of Motile multiciliated cell progenitors.
p73 (show ARHGAP24 Proteins) drives multiciliogenesis, both through transcriptional activation of a master ciliogenesis transcription factor FoxJ1 (show FOXJ1 Proteins) and through regulation of multiple genes central to ciliogenesis.
The p73 (show ARHGAP24 Proteins) acts as a critical regulator of multiciliogenesis in its capacity as a sequence-specific transcription factor, through genomic binding and regulation of genes.
Data show that the Mdm4 (show MDM4 Proteins)-p73 (show ARHGAP24 Proteins) axis cannot override the dominant role of p53 (show TP53 Proteins) in development and tumorigenesis and that Mdm4 (show MDM4 Proteins) and p73 (show ARHGAP24 Proteins) interaction during development and tumorigenesis suggests new insight into the role of p53 (show TP53 Proteins) family members.
In vivo inhibition of both p63 (show CKAP4 Proteins) and p73 (show ARHGAP24 Proteins) in combination accelerates tumor regression and increases survival of p53 (show TP53 Proteins)-deficient mice.
Results indicate that p73 (show ARHGAP24 Proteins) regulates basal and starvation-induced fuel metabolism in the liver, a finding that is likely to be highly relevant for metabolism-associated disorders, such as diabetes and cancer.
MDM2 (show MDM2 Proteins) mediates p73 (show ARHGAP24 Proteins) ubiquitination
p73 (show ARHGAP24 Proteins) is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF (show VEGFA Proteins) and TGFbeta (show TGFB1 Proteins) signaling
High TP73 expression is associated with Metastasis of Hepatocellular Carcinoma.
The reduction of tumor protein p63 (show TP63 Proteins) and tumor protein p73 isoforms, rather than alteration of DeltaN isoform expression, exerted a significant functional repercussion on cell death and proliferation in hepatitis B virus -expressing HepB cells.
p73 is epigenetically silenced in chondrosarcoma due to promoter methylation, which suggests the utility of p73 methylation as a biomarker.
A considerable number of lymphoma patients lacked the expression of either or both isoforms, while all lymphoid leukemia patients expressed both isoforms. The expression pattern differences of p73 isoforms may reflect differences in the biology of these malignancies.
TAp73beta upregulates pro-IL-1beta (show IL1B Proteins) mRNA and processed IL-1beta (show IL1B Proteins) protein. In addition, analysis of breast and lung cancer patient cohorts demonstrated that interaction between p73 and IL-1beta (show IL1B Proteins) predicts a negative survival outcome in these cancers.
analysis of how trifluoroethanol induces a conformational transition in the C-terminal sterile alpha motif (SAM (show TTN Proteins)) of human p73
The findings of this study suggested that the polymorphism G4C14-to-A4T14 in p73 gene might be associated with severe spermatogenesis impairment and could affect the susceptibility to male infertility with severe spermatogenesis impairment in Chinese population.
Authors confirmed that miR (show MLXIP Proteins)-200a could directly bind to TP73-AS1 and the 3'UTR of HMGB1 (show HMGB1 Proteins); TP73-AS1 competed with HMGB1 (show HMGB1 Proteins) for miR (show MLXIP Proteins)-200a binding.
The p73 gene may play a role as a tumor suppressor in the colorectal cancer progression.
TP73 expression in cervical cancer was significantly higher than that in normal cervical squamous epithelium (meta-analysis)
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.
tumor protein p73
, tumor protein p73-like
, p53-like transcription factor
, p53-related protein
, transformation related protein 73