Browse our BST2 Proteins (BST2)

Full name:
Bone Marrow Stromal Cell Antigen 2 Proteins (BST2)
On are 23 Bone Marrow Stromal Cell Antigen 2 (BST2) Proteins from 9 different suppliers available. Additionally we are shipping BST2 Antibodies (177) and BST2 Kits (8) and many more products for this protein. A total of 232 BST2 products are currently listed.
2310015I10Rik, Bst-2, BST2, C87040, CD317, DAMP-1, Damp1, GREG, TETHERIN
list all proteins Gene Name GeneID UniProt
BST2 684 Q10589
BST2 69550 Q8R2Q8
BST2 378947 Q811A2

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BST2 Proteins (BST2) by Origin

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Top referenced BST2 Proteins

  1. Human BST2 Protein expressed in Escherichia coli (E. coli) - ABIN667927 : Schubert, Zhai, Sandrin, Eckert, Garcia-Maya, Saul, Sundquist, Steiner, Hill: Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 2 references for 667927

More Proteins for BST2 Interaction Partners

Chimpanzee Bone Marrow Stromal Cell Antigen 2 (BST2) interaction partners

  1. The cytoplasmic domain of HIV-1 Vpu contributes to the physical interaction with, and functional antagonism of chimpanzee BST-2.

Rhesus Monkey Bone Marrow Stromal Cell Antigen 2 (BST2) interaction partners

  1. the detected relationship between BST2 expression and viral load as well as with MX1 (show MX1 Proteins) indicate a common regulation by the interferon (show IFNA Proteins) response and suggest rather limited influence of BST2 in vivo on the simian immunodeficiency virus infection outcome

  2. Data suggest that rhesus macaque tetherin and Simian immunodeficiency virus Nef undergo physical interaction leading to removal of tetherin from plasma membrane by clathrin-mediated endocytosis.

  3. A 5-amino-acid sequence in the rhesus BST-2 cytoplasmic domain accounts for the interaction with Vpu and for rhesus BST-2 antagonism by HIV-1 Vpu.

  4. Simian immunodeficiency virus infection results in rapid upregulation of BST-2 on peripheral blood lymphocytes.

Pig (Porcine) Bone Marrow Stromal Cell Antigen 2 (BST2) interaction partners

  1. Indirect immunofluorescence assay and western blot analysis showed that the MAb was specifically reacted with the overexpressed porcine BST-2 protein in Vero cells. The specific MAb of porcine BST-2 provides a valuable tool for further studies of BST-2 to restrict virus infection

  2. This antibody only reacted with porcine BST-2 protein and not with human, monkey, or mouse BST-2 protein

  3. PRRSV counteract the antiviral functions of IFITM1 (show IFITM1 Proteins) and Tetherin by the interaction of the Nsp3 (show SH2D3C Proteins) with IFITM1 (show IFITM1 Proteins) and the E protein with Tetherin.

  4. The BST2 had antiviral activity against vesicular stomatitis virus, avian influenza virus and Porcine reproductive and respiratory syndrome virus.

Human Bone Marrow Stromal Cell Antigen 2 (BST2) interaction partners

  1. BST-2 and HIV-2 Env (show ERVW-1 Proteins) proteins interact through their ectodomain but residues involved are not clearly defined. In this study, we demonstrated the importance of the asparagine residue at position 659 in the HIV-2 gp36 (show PDPN Proteins) ectodomain for the anti-tetherin function. This study also demonstrated the involvement of the HIV-2 Env (show ERVW-1 Proteins) cytoplasmic tail in this antagonistic role.

  2. Despite the influence of rs919266 and rs9576 on BST2 expression being still undetermined, a preventive role by BST2 polymorphisms was found during HIV-1 infection.

  3. The authors demonstrated that BST2 restricts the release of Japanese encephalitis virus whose budding occurs at the endoplasmic reticulum-Golgi intermediate compartment, and in turn, Japanese encephalitis virus downregulates BST2 expression via envelope protein E (show CRISP1 Proteins).

  4. These results suggest that BST2 plays an important role in the progression of renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)), and, because BST2 is expressed on the cell membrane, BST2 is a good therapeutic target for RCC (show XRCC1 Proteins).

  5. findings show that BST-2 upregulation by IFN-beta (show IFNB1 Proteins) and interleukin-27 (IL-27 (show IL27 Proteins)) also increases the surface expression of Env (show ERVW-1 Proteins) and thus boosts the ability of CD4mc to sensitize HIV-1-infected cells to ADCC by sera from HIV-1-infected individuals.

  6. study found that tetherin expression on hematopoietic cells resulted in the specific reduction of Moloney murine leukemia virus cell-free plasma viremia but not the number of infected hematopoietic cells

  7. BST2 is involved in the osteogenic differentiation of bone marrow stromal cells via the regulation of the BMP2 (show BMP2 Proteins) signaling pathway.

  8. The authors show that orthobunyaviruses viruses with human tropism (Oropouche virus and La Crosse virus) are restricted by sheep BST-2 but not by the human orthologue, while viruses with ruminant tropism (Schmallenberg virus and others) are restricted by human BST-2 but not by the sheep orthologue.

  9. Thus, efficient human immunodeficiency virus type 1 release from infected cells seems to play an important role in the spread of the virus in the human population and requires a fully functional Vpu protein that counteracts human tetherin.

  10. BST-2 restricts influenza A virus release and is countered by the viral M2 protein.

Mouse (Murine) Bone Marrow Stromal Cell Antigen 2 (BST2) interaction partners

  1. Tetherin-mediated retention of R-defective virions on the cell surface could enhance syncytium formation.

  2. Bone marrow stromal antigen 2-mediated dendritic cell activation as a critical mechanism for how Tetherin influenced retrovirus cell-mediated immune responses that subsequently inhibited retrovirus replication in vivo.

  3. BST-2 does not have a role in modulating Influenza A Virus in the mouse model of infection

  4. Although Bst2 prevented Measles virus (MV) release from nonneuronal cells, its deletion had no effect on viral pathogenesis in MV-challenged mice.

  5. BST-2 contributes to the emergence of neoplasia and malignant progression of breast cancer. BST-2 enhances cancer cell adhesion, anchorage-independency, migration, and invasion.

  6. BST-2 protects lymphoid tissues from Chikungunya virus (CHIKV) infection and regulates CHIKV-induced inflammatory response by the host.

  7. TLR4 (show TLR4 Proteins) and PI3K effects on BST-2 induction are at the level of transcription.

  8. Tetherin acts as a modulator of the cell-mediated immune response against retrovirus infection in vivo.

  9. These findings suggest that BST2 antagonism by Vpu is critical for efficient early viral expansion and dissemination during acute infection and as such is likely to confer HIV-1 increased transmission fitness.

  10. These data suggest that overexpression of BST-2 in carcinoma tissues could not be attributed to interferons but to a yet to be determined factor that upregulates BST-2 once oncogenesis is initiated.

BST2 Protein Profile

Protein Summary

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined\; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis.

Alternative names and synonyms associated with BST2

  • bone marrow stromal cell antigen 2 (BST2)
  • bone marrow stromal cell antigen 2 (Bst2)
  • 2310015I10Rik protein
  • Bst-2 protein
  • BST2 protein
  • C87040 protein
  • CD317 protein
  • DAMP-1 protein
  • Damp1 protein
  • GREG protein
  • TETHERIN protein

Protein level used designations for BST2

bone marrow stromal antigen 2 , bone marrow stromal cell antigen 2 , tetherin , BST-2 , HM1.24 antigen , NPC-A-7 , DAMP-1 protein homolog , protein DAMP-1

455837 Pan troglodytes
609654 Canis lupus familiaris
618737 Bos taurus
719092 Macaca mulatta
100302088 Sus scrofa
100359386 Pongo abelii
100652388 Felis catus
684 Homo sapiens
69550 Mus musculus
378947 Rattus norvegicus
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