Browse our IL27 Receptor alpha Proteins (IL27RA)

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Interleukin 27 Receptor, alpha Proteins (IL27RA)
On are 14 Interleukin 27 Receptor, alpha (IL27RA) Proteins from 8 different suppliers available. Additionally we are shipping IL27 Receptor alpha Antibodies (106) and IL27 Receptor alpha Kits (2) and many more products for this protein. A total of 130 IL27 Receptor alpha products are currently listed.
CRL1, IL-27R, IL-27RA, IL27R, IL27RA, Tccr, WSX-1, Wsx1, zcytor1
list all proteins Gene Name GeneID UniProt
IL27RA 9466 Q6UWB1
IL27RA 50931 O70394
IL27RA 288905  

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IL27 Receptor alpha Proteins (IL27RA) by Origin

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Top referenced IL27 Receptor alpha Proteins

  1. Human IL27 Receptor alpha Protein expressed in Human Cells - ABIN2002953 : Chen, Ghilardi, Wang, Baker, Xie, Gurney, Grewal, de Sauvage: Development of Th1-type immune responses requires the type I cytokine receptor TCCR. in Nature 2000 (PubMed)
    Show all 4 references for 2002953

  2. Human IL27 Receptor alpha Protein expressed in HEK-293 Cells - ABIN2181379 : Sprecher, Grant, Baumgartner, Presnell, Schrader, Yamagiwa, Whitmore, OHara, Foster: Cloning and characterization of a novel class I cytokine receptor. in Biochemical and biophysical research communications 1998 (PubMed)
    Show all 4 references for 2181379

More Proteins for IL27 Receptor alpha Interaction Partners

Human Interleukin 27 Receptor, alpha (IL27RA) interaction partners

  1. These results identify IL-27 (show IL27 Proteins) and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.

  2. Findings demonstrated that IL-27 (show IL27 Proteins) and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 (show IL27 Proteins) can modulate immune properties of astrocytes and infiltrating immune cells

  3. The significant expression of IL-27 (show IL27 Proteins) in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor (show EBI3 Proteins) pair is detrimental in TB.

  4. natural sIL (show PMEL Proteins)-27Ralpha binds rIL (show PDLIM4 Proteins)-27, inhibits IL-27 (show IL27 Proteins) binding to its cell surface receptor, and is a potent inhibitor of IL-27 (show IL27 Proteins) signaling, as shown by its ability to specifically block IL-27 (show IL27 Proteins)-mediated STAT (show STAT1 Proteins) activation, at low molar excess over IL-27 (show IL27 Proteins).

  5. Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes.

  6. TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration.

  7. Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.

  8. WSX-1 is essential for transcriptional activation of STAT1 (show STAT1 Proteins) and for augmenting the induction of T-bet expression during initiation of Th1 (show TH1L Proteins) cell differentiation.

  9. WSX-1 together with the cytokine receptor (show EBI3 Proteins) gp130 (show IL6ST Proteins) constitutes a functional signal-transducing receptor for IL-27 (show IL27 Proteins).

  10. IL-27R possesses hematopoietic cell-transforming properties

Mouse (Murine) Interleukin 27 Receptor, alpha (IL27RA) interaction partners

  1. The combination of mutant p53 (show TP53 Proteins) & IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis, whereas either gene alone has no effects on the liver.

  2. IL-10 (show IL10 Proteins) production by CD4 (show CD4 Proteins)(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 (show IL27 Proteins) receptor signaling that is supported after CD4 (show CD4 Proteins)(+) T cell priming by ICOS (show ICOS Proteins) signaling.

  3. The significant expression of IL-27 (show IL27 Proteins) in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor (show LEPR Proteins) pair is detrimental in TB.

  4. IL-27R-mediated regulation of IL-17 (show IL17A Proteins) controls the development of respiratory syncytial virus-associated pathogenesis.

  5. CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice

  6. The loss of IL-27R signaling across the whole mouse resulted in reduced viral control and a slight increase in the number of virus-specific CD4 (show CD4 Proteins) T cells at early stages of viral infection.

  7. Diminution of the Th1 response in infected Il27ra mice in vivo by neutralization of IL-12p40 attenuated CCR5 expression.

  8. These findings establish a novel antiatherogenic role for IL-27 (show IL27 Proteins) receptor signaling, which acts to suppress the production of proinflammatory cytokines and chemokines and to curb the recruitment of inflammatory myeloid cells into atherosclerotic aortas.

  9. In Th1 (show HAND1 Proteins)-dependent autoinflammatory lesions, IL-27Ralpha has a biphasic role in vivo, initially pathogenic, but ultimately playing a protective role by regulating immune responses and attenuating disease.

  10. Data show that the deletion of Il27ra ameliorates pathology in the pristane-induced SLE model.

IL27 Receptor alpha (IL27RA) Protein Profile

Protein Summary

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.

Alternative names and synonyms associated with IL27 Receptor alpha (IL27RA)

  • interleukin 27 receptor, alpha (IL27RA)
  • interleukin 27 receptor, alpha (Il27ra)
  • CRL1 protein
  • IL-27R protein
  • IL-27RA protein
  • IL27R protein
  • IL27RA protein
  • Tccr protein
  • WSX-1 protein
  • Wsx1 protein
  • zcytor1 protein

Protein level used designations for IL27RA

interleukin 27 receptor, alpha , class I cytokine receptor , interleukin-27 receptor subunit alpha , type-I T cell cytokine receptor , IL-27 receptor subunit alpha , IL-27R subunit alpha , IL-27R-alpha , T-cell cytokine receptor type 1 , cytokine receptor WSX-1 , cytokine receptor-like 1 , type I T-cell cytokine receptor , IL-27RA , T cell cytokine receptor , T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1 , cytokine receptor family, class 1 (WSXWS), member 1

456370 Pan troglodytes
484907 Canis lupus familiaris
514529 Bos taurus
717549 Macaca mulatta
9466 Homo sapiens
50931 Mus musculus
288905 Rattus norvegicus
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