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Browse our FDFT1 Proteins (FDFT1)

Full name:
Farnesyl-Diphosphate Farnesyltransferase 1 Proteins (FDFT1)
On are 11 Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) Proteins from 5 different suppliers available. Additionally we are shipping FDFT1 Antibodies (105) and FDFT1 Kits (26) and many more products for this protein. A total of 149 FDFT1 products are currently listed.
DGPT, DKFZp459C1712, ERG9, fdft1, SQS, SS
list all proteins Gene Name GeneID UniProt
FDFT1 14137 P53798
FDFT1 29580 Q02769
FDFT1 2222 P37268

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FDFT1 Proteins (FDFT1) by Origin

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Mouse (Murine) Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) interaction partners

  1. This study demonistrated that fdft1 is regulate the neuronal cholesterol synthesis during neurite outgrowth.

  2. Result provides the first in vivo evidence that SS plays a regulatory role in cholesterol metabolism through modulation of HMG-CoA reductase (show HMGCR Proteins) activity and cholesterol biosynthesis.

  3. VEGF (show VEGFA Proteins) expression, APOPTOSIS, AND ANGIOGENESIS in squalene synthase -ablated neural stem cells wERE strongly upregulated

Human Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) interaction partners

  1. The results indicate that the ennea-peptide CLSPHSMFC, tetra-peptides SMFC, CKTE, and WHQW can effectively inhibit Squalene Synthase activities (IC50 values equal to 64, 76, 87, and 90 muM, respectively)

  2. The minor allele in FDFT1 was associated with advanced fibrosis in the non-steatotic but not in the steatotic subgroup in patients with chronic hepatitis C.

  3. Up-regulation of SQS promotes metastasis of lung cancer by enhancing tumor necrosis factor-alpha receptor (show TNFRSF1A Proteins) 1 and nuclear factor-kappaB activation and matrix metallopeptidase (show ECEL1 Proteins) 1 expression.

  4. Several critical residues that are involved in binding of NADPH (show NQO1 Proteins) have been identified in the active site of squalene synthase.

  5. HCV infection increases FDFT1 protein level but not FDFT1 mRNA level.

  6. ABHD5 (show ABHD5 Proteins), PGRMC1 (show PGRMC1 Proteins) and SQS are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features.

  7. FDFT1 and its encoded enzyme, squalene synthase, may play an important role in prostate cancer development and its aggressive phenotypes.

  8. CTSB (show CTSB Proteins) and FDFT1 are excluded as candidates for keratolytic winter erythema

  9. NASH (show SAMSN1 Proteins) is intimately related to fibrosis progression, the FDFT1 SNP is a good candidate for a link with inflammation and fibrosis.

  10. In multivariate models adjusted for age, body mass index, diabetes, waist/hip ratios, and levels of glycated hemoglobin (show HBB Proteins), the NAFLD activity score was associated with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1)

FDFT1 Protein Profile

Protein Summary

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

Alternative names and synonyms associated with FDFT1

  • farnesyl-diphosphate farnesyltransferase 1 (FDFT1)
  • farnesyl-diphosphate farnesyltransferase 1 (fdft1)
  • farnesyl-diphosphate farnesyltransferase 1 (LOC100217567)
  • farnesyl diphosphate farnesyl transferase 1 (Fdft1)
  • farnesyl-diphosphate farnesyltransferase 1 (Fdft1)
  • si:ch73-107c13.2 (si:ch73-107c13.2)
  • DGPT protein
  • DKFZp459C1712 protein
  • ERG9 protein
  • fdft1 protein
  • SQS protein
  • SS protein

Protein level used designations for FDFT1

farnesyl-diphosphate farnesyltransferase 1 , squalene synthase , SS , SQS , Squalene synthetase , FPP:FPP farnesyltransferase , squalene synthase-like , farnesyl-diphosphate farnesyltransferase , squalene synthetase , farnesyl diphosphate farnesyltransferase , presqualene-di-diphosphate synthase

696396 Macaca mulatta
740684 Pan troglodytes
100029000 Monodelphis domestica
100173463 Pongo abelii
100216201 Xenopus (Silurana) tropicalis
100479603 Ailuropoda melanoleuca
100560926 Anolis carolinensis
100603333 Nomascus leucogenys
100217567 Taeniopygia guttata
14137 Mus musculus
29580 Rattus norvegicus
422038 Gallus gallus
2222 Homo sapiens
477362 Canis lupus familiaris
100312971 Sus scrofa
281767 Bos taurus
100345480 Oryctolagus cuniculus
100714445 Cavia porcellus
101119109 Ovis aries
571911 Danio rerio
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