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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A ELISA Kits), sp1 and sod1 (show SOD1 ELISA Kits) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
decreased expression of transcription factor Sp1 contributes to suppression of SHIP2 (show INPPL1 ELISA Kits) in gastric cancer cells.
this study shows that IL-10 (show IL10 ELISA Kits) production by CD20 (show MS4A1 ELISA Kits)+ B cells among peripheral blood mononuclear cell is enhanced by bendamustine via p38 MAP kinase (show MAPK14 ELISA Kits)-Sp1 (show PSG1 ELISA Kits) pathway
During inflammatory conditions, AP-1 (show FOSB ELISA Kits) and Sp1 (show PSG1 ELISA Kits) sustained the expression of ADAMTS7 (show ADAMTS7 ELISA Kits), and ADAMTS7 (show ADAMTS7 ELISA Kits) sustained the expression of catabolic genes in nucleus pulposus cells
there is a SP1 (show PSG1 ELISA Kits) site in DKK1 (show DKK1 ELISA Kits) promoter region; overexpression of SP1 (show PSG1 ELISA Kits) could increase DKK1 (show DKK1 ELISA Kits) promoter activity in a dose dependent manner; and siRNA inhibition of SP1 (show PSG1 ELISA Kits) expression reduced DKK1 (show DKK1 ELISA Kits) promoter activity and decreased the expression of DKK1 (show DKK1 ELISA Kits) protein.
The data demonstrated that Sp1 transcription factor protein (show SSRP1 ELISA Kits) expression is induced by TNFalpha (show TNF ELISA Kits) and interleukin1 beta.
It was found that miR411 was significantly downregulated in breast cancer, and associated with lymph node metastasis and histological grade. Additionally, it was observed that miR411 suppressed cell growth, migration and invasion in the breast cancer cells. miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer.
the present study suggests that GAPDH (show GAPDH ELISA Kits) plays an important role in cancer metastasis by affecting EMT (show ITK ELISA Kits) through regulation of Sp1 (show PSG1 ELISA Kits)-mediated SNAIL (show SNAI1 ELISA Kits) expression.
the primary activating regulatory region of human IRF5 (show IRF5 ELISA Kits) was located in its minimal promoter region between nucleotides -179 and +62. In addition, it was shown that Sp1 (show PSG1 ELISA Kits) was able to bind to the multiple sites in IRF5 (show IRF5 ELISA Kits) promoter region, and was involved in the transcriptional regulation of IRF5 (show IRF5 ELISA Kits) at the basal level.
melatonin suppresses the motility of NPC (show NPC1 ELISA Kits) by regulating TPA (show PLAT ELISA Kits)-induced MMP-9 (show MMP9 ELISA Kits) gene expression via inhibiting SP-1 (show PSG1 ELISA Kits)-DNA binding ability. The results provide a functional link between melatonin-mediated SP-1 (show PSG1 ELISA Kits) regulation and the antimetastatic actions of melatonin on nasopharyngeal carcinoma.
miRNA-223 specifically regulates the epithelial-mesenchymal transition (EMT (show ITK ELISA Kits))process of gastric cancer cells through its target gene Sp1 (show PSG1 ELISA Kits). Overexpression of miRNA-223 in these cells inhibits EMT (show ITK ELISA Kits) via the miRNA-223/Sp1 (show PSG1 ELISA Kits)/EMT (show ITK ELISA Kits) pathway
study demonstrates the co-expression of DLX3 (show DLX3 ELISA Kits), PPARG (show PPARG ELISA Kits) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH ELISA Kits) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (show FASN ELISA Kits) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP ELISA Kits) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP ELISA Kits) promoter and its activity.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
miR (show MLXIP ELISA Kits)-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 (show COL11A1 ELISA Kits) gene in chondrocytes.
In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 ELISA Kits) gene was regulated by E2F1 (show E2F1 ELISA Kits) and Sp1, and was then gradually replaced under the control of both MyoD (show MYOD1 ELISA Kits) and myogenin (show MYOG ELISA Kits).
Data indicate that Sp1 and AP-1 (show JUN ELISA Kits)-related factors are involved in the regulation of MFG-E8 (show MFGE8 ELISA Kits) gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.
Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor (show SP3 ELISA Kits) members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
age-dependent alteration in the Fmr-1 (show FMR1 ELISA Kits) gene expression is associated with Sp1 interaction with Fmr-1 (show FMR1 ELISA Kits) promoter which in turn might be related with cognitive development during brain maturation and aging.
The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate (show GRIN1 ELISA Kits) signalling pathways in schizophrenia
The transcription factor SP1 is induced in brain by ischemia/reperfusion.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1