Browse our anti-TXNRD1 (TXNRD1) Antibodies

Full name:
anti-Thioredoxin Reductase 1 Antibodies (TXNRD1)
On are 132 Thioredoxin Reductase 1 (TXNRD1) Antibodies from 20 different suppliers available. Additionally we are shipping TXNRD1 Kits (37) and TXNRD1 Proteins (33) and many more products for this protein. A total of 206 TXNRD1 products are currently listed.
cb682, fb83a08, GB14972, GRIM-12, MGC85342, NADPH-dependent thioredoxin reductase C, T32G6.20, T32G6_20, Tr, TR1, TRXR1, TXNR, wu:fb83a08
list all antibodies Gene Name GeneID UniProt
TXNRD1 7296 Q16881
TXNRD1 58819 O89049
TXNRD1 50493 Q9JMH6

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Top referenced anti-TXNRD1 Antibodies

  1. Human Polyclonal TXNRD1 Primary Antibody for IF (p), IHC (p) - ABIN1386102 : Kaya, Çiçek, Erdi, Findik, Karatas, Esen, Keskin, Kalkan: Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma. in Molecular and clinical oncology 2016 (PubMed)

  2. Human Polyclonal TXNRD1 Primary Antibody for ELISA, WB - ABIN184781 : Gasdaska, Gasdaska, Cochran, Powis: Cloning and sequencing of a human thioredoxin reductase. in FEBS letters 1995 (PubMed)

More Antibodies against TXNRD1 Interaction Partners

Arabidopsis thaliana Thioredoxin Reductase 1 (TXNRD1) interaction partners

  1. NTRC is highly sensitive to rapidly changing light intensities.NTRC is not responsible for 'metabolism-related' regulation of the ATP synthase.

  2. cooperative control of chloroplast functions via the FTR/Trx (show TXN Antibodies) and NTRC pathways is essential for plant viability

  3. These data uncover a new role for NTRC in the control of photosynthetic yield.

  4. An Arabidopsis thaliana double knockout mutant lacking NTRC and Srx (show SRX1 Antibodies) shows a phenotype similar to the ntrc mutant, while the srx (show SRX1 Antibodies) mutant resembles wild-type plants. NTRC deficiency causes reduced overoxidation of 2-Cys (show DNAJC5 Antibodies) peroxiredoxins.

  5. NADPH thioredoxin reductase C is involved in redox regulation of the Mg-chelatase I subunit in Arabidopsis thaliana chloroplasts

  6. interaction of chloroplast 2-Cys (show DNAJC5 Antibodies) peroxiredoxin with NADPH (show NQO1 Antibodies)-thioredoxin reductase C (NTRC) and thioredoxin (show TXN Antibodies) x

  7. The strongest reduction in ntrc growth occurred under photoperiods with nights longer than 14 h, whereas knockout of the NTRC gene did not alter the circadian-clock-controlled growth. Lack of NTRC modulated chloroplast reactive oxygen species metabolism.

  8. heat shock-mediated holdase chaperone function of NTRC is responsible for the increased thermotolerance of Arabidopsis and the activity is significantly supported by NADPH

  9. analysis of electron transfer pathways and dynamics of chloroplast NADPH-dependent thioredoxin reductase C (NTRC)

  10. NADPH (show NQO1 Antibodies)-thioredoxin reductase C (NTRC), previously reported as exclusive to green tissues, is also expressed in nonphotosynthetic tissues of Arabidopsis thaliana.

Caenorhabditis elegans (C. elegans) Thioredoxin Reductase 1 (TXNRD1) interaction partners

  1. Selenoprotein TRXR-1 and GSR-1 (show GSR Antibodies) are essential for removal of old cuticle during molting in Caenorhabditis elegans.

Human Thioredoxin Reductase 1 (TXNRD1) interaction partners

  1. Inhibition of thioredoxin reductase-1 by brevetoxin-2 is via the formation of a Michael adduct between selenocysteine and the alpha, beta-unsaturated aldehyde moiety of the toxin.

  2. Here, the authors use a novel assay to demonstrate that the reduction in non-native disulfides requires NADPH (show NQO1 Antibodies) as the ultimate electron donor, and a robust cytosolic thioredoxin (show TXN Antibodies) system, driven by thioredoxin reductase 1 (TrxR1 or TXNRD1).

  3. Taken together, these findings indicate that auranofin inhibition of TrxR activity in Hep3B cells activates ROS (show ROS1 Antibodies)- and caspase (show CASP3 Antibodies)-dependent apoptotic signaling pathways and triggers cancer cell death.

  4. It was observed that the combination of redox/protonation states of the N-terminal (FAD (show BRCA2 Antibodies) and Cys59/64) and C-terminal (Cys497/Selenocysteine498) redox centers defines the preferred relative positions and allows for the flexible arm to work as the desired electron "shuttle."

  5. Our results clearly demonstrate that DIMC can synergistically enhance the cancer cell killing when combined with radiation by targeting thioredoxin (show TXN Antibodies) system.

  6. thioredoxin reductase is inhibited by plumbagin, which leads to apoptosis in HL-60 cells

  7. TXNRD1 variants may favor anti-tuberculosis drug-induced hepatotoxicity susceptibility in females and nonsmokers.

  8. Our findings demonstrate that elevated TrxR1 levels correlate with the acquisition of bortezomib resistance in MM. We propose considering TrxR1-inhibiting drugs, such as auranofin, either for single agent or combination therapy to circumvent bortezomib-resistance and improve survival outcomes of MM patients.

  9. Cardamonin exposure and selenium availability regulate expression of HO-1 (show HMOX1 Antibodies), GPX2 (show GPX2 Antibodies) and TrxR1 in human intestinal cells.

  10. Under the conditions of inhibition of TrxRs in cells, Parthenolide (PTL (show PNLIP Antibodies)) does not cause significant alteration of cellular thiol homeostasis, supporting selective target of TrxRs by PTL (show PNLIP Antibodies). Importantly, overexpression of functional TrxR1 or Trx1 (show MLL Antibodies) confers protection, whereas knockdown of the enzymes sensitizes cells to PTL (show PNLIP Antibodies) treatment.

Pig (Porcine) Thioredoxin Reductase 1 (TXNRD1) interaction partners

  1. The developmental expression of cytosolic glutathione peroxidase (show GPX1 Antibodies) and TRXR1 during fetal development and the effect of maternal selenium consumption on the expression of these proteins are reported.

  2. regenerated coronary endothelial cells exhibit downregulation of thioredoxin reductase

Cow (Bovine) Thioredoxin Reductase 1 (TXNRD1) interaction partners

  1. These results suggest that thioredoxin reductase (show PRDX5 Antibodies) may act as a positive regulator of NF-kappa B (show NFKB1 Antibodies) and may play an important role in the cellular inflammatory response.

  2. data provide evidence for the involvement of the Trx/TrxR (show GSR Antibodies) system, in the regulation of haem oxygenase-1 expression in aortic endothelial cells during pro-oxidant challenge

Mouse (Murine) Thioredoxin Reductase 1 (TXNRD1) interaction partners

  1. GSR (show GSR Antibodies) is not essential for the maintenance of antioxidant defenses in mouse cochlea; the thioredoxin/thioredoxin (show TXN Antibodies) reductase (show PRDX2 Antibodies) system can probably operate as a functional backup for GSR (show GSR Antibodies).

  2. TrxR1 represents a novel therapeutic target to prevent oxygen-mediated neonatal lung injury through Nrf2 (show NFE2L2 Antibodies).

  3. The results demonstrate that DATS protects against oxidative stress-induced (show SQSTM1 Antibodies) DNA damage and apoptosis in C2C12 cells in part through the activation of Nrf2 (show NFE2L2 Antibodies)-mediated TrxR1 induction via the ERK (show EPHB2 Antibodies) signaling pathway.

  4. Collectively, our results suggest that MsrA (show MSR1 Antibodies) protects hepatocytes from APAP-induced cytotoxicity through the modulation of TXNRD1 expression.

  5. the timely upregulation of Trx1 (show TXN Antibodies)/TrxR1 and the active control of intracellular redox status is critical for the survival of thymocytes during and short after positive selection.

  6. Considering the variable expression levels of Sep15 (show SEP15 Antibodies) and TR1 found within the human population, our results provide insights into new roles of selenoproteins in cancer

  7. Data suggest TXNRD1 and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.

  8. Augmentation of GSH systems by TrxR1 inhibition could represent a promising therapeutic approach to attenuate oxidant-mediated lung injury and improve patient outcomes.

  9. Because the N-terminal domain of Sepp1 (show SEPP1 Antibodies) has a thioredoxin (show TXN Antibodies) fold, Sepp1 (show SEPP1 Antibodies)(UF) were compared with full-length Sepp1 (show SEPP1 Antibodies), Sepp1 (show SEPP1 Antibodies)(Delta240-361), and Sepp1 (show SEPP1 Antibodies)(U40S) as a substrate of thioredoxin reductase-1 (TrxR1).

  10. Sec-containing TrxR1 is absolutely required for self-sufficient growth of MEFs under high-glucose conditions, owing to an essential importance of this enzyme for elimination of glucose-derived H2O2.

TXNRD1 Antigen Profile

Antigen Summary

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

Alternative names and synonyms associated with TXNRD1

  • thioredoxin reductase 1 (TXNRD1) antibody
  • thioredoxin reductase 1 (txnrd1) antibody
  • thioredoxin reductase 1 (Trxr-1) antibody
  • NADPH-dependent thioredoxin reductase C (NTRC) antibody
  • Protein TRXR-1 (trxr-1) antibody
  • thioredoxin reductase 1 (Txnrd1) antibody
  • cb682 antibody
  • fb83a08 antibody
  • GB14972 antibody
  • GRIM-12 antibody
  • MGC85342 antibody
  • NADPH-dependent thioredoxin reductase C antibody
  • T32G6.20 antibody
  • T32G6_20 antibody
  • Tr antibody
  • TR1 antibody
  • TRXR1 antibody
  • TXNR antibody
  • wu:fb83a08 antibody

Protein level used designations for TXNRD1

thioredoxin reductase 1, cytoplasmic , thioredoxin reductase 3 , thioredoxin reductase 1 , thioredoxin reductase 1, cytoplasmic-like , KM-102-derived reductase-like factor , gene associated with retinoic and IFN-induced mortality 12 protein , gene associated with retinoic and interferon-induced mortality 12 protein , oxidoreductase , thioredoxin reductase GRIM-12 , thioredoxin reductase TR1 , TR , redox enzyme thioredoxin reductase , NADPH-dependent thioredoxin reductase , selenoprotein oxidoreductase , TR alpha

100067923 Equus caballus
701062 Macaca mulatta
352924 Danio rerio
410032 Apis mellifera
447610 Xenopus laevis
467112 Pan troglodytes
100015072 Monodelphis domestica
100401029 Callithrix jacchus
100479058 Ailuropoda melanoleuca
100495372 Xenopus (Silurana) tropicalis
100568111 Anolis carolinensis
100600391 Nomascus leucogenys
818766 Arabidopsis thaliana
177466 Caenorhabditis elegans
7296 Homo sapiens
396681 Sus scrofa
58819 Rattus norvegicus
474536 Canis lupus familiaris
282388 Bos taurus
50493 Mus musculus
418082 Gallus gallus
100356179 Oryctolagus cuniculus
100718723 Cavia porcellus
100174180 Pongo abelii
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