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Browse our Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Proteins (CTNNA1)

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Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Proteins (CTNNA1)
On are 7 Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) Proteins from 5 different suppliers available. Additionally we are shipping Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Antibodies (164) and Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Kits (25) and many more products for this protein. A total of 199 Catenin (Cadherin-Associated Protein), alpha 1, 102kDa products are currently listed.
2010010M04Rik, a-cat, AA517462, AI988031, Alpha-Cat, alpha-catenin, alpha-ctn, alphacat, CAP102, Catna1, CG17947, CT39986, ctnna, CTNNA1, Dalpha-cat, DalphaC, Dalphacat, DgriGH19548, dgri_GLEANR_3829, Dmcatp, Dmel\\CG17947, GH19548
list all proteins Gene Name GeneID UniProt
CTNNA1 12385 P26231
CTNNA1 1495 P35221
Rat CTNNA1 CTNNA1 307505  

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Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Proteins (CTNNA1) by Origin

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More Proteins for Catenin (Cadherin-Associated Protein), alpha 1, 102kDa Interaction Partners

Fruit Fly (Drosophila melanogaster) Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

  1. Increased Rap1 (show TERF2IP Proteins) activity restricts epithelial invagination in an alpha-catenin-dependent manner.

  2. alpha-Cat mutant phenotype can be rescued by the expression of a DE-cadherin::alpha-Catenin fusion protein, which argues against an essential cytosolic, cadherin-independent role of Drosophila alpha-Catenin

  3. alpha-catenin and p120(ctn (show CTNND1 Proteins)) are key players in a mechanism of recruiting Rho1 to its sites of action.

Zebrafish Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

  1. Depletion of alphaE-catenin caused a defect in radial intercalation that was associated with decreased cell-cell adhesion, in a similar manner to E-cadherin (show CDH1 Proteins) depletion. Depletion of alphaE-catenin also caused deep cells to have plasma membrane blebbing.

Mouse (Murine) Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

  1. Two Dtna (show DTNA Proteins) interactors, alpha-catulin (show CTNNAL1 Proteins) (phosphorylation independent) and Grb2 (show GRB2 Proteins) (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.

  2. alphaE-catenin inhibits beta4 integrin-mediated activation of SRC (show SRC Proteins) tyrosine kinase (show TYRO3 Proteins)

  3. E-cadherin (show CDH1 Proteins)/alphaE-catenin chimeras used previously do not mimic alphaE-catenin in the native CCC, and imply that both CCC-bound monomer and cytosolic homodimer alphaE-catenin are required for strong cell-cell adhesion.

  4. Loss of alpha-catenin elicits a cholestatic response and impairs liver regeneration

  5. alphaE-catenin binding to filamentous actin favors assembly of unbranched filament bundles that are protected from severing over more dynamic, branched filament arrays.

  6. Fusing VE-cadherin (show CDH5 Proteins) to alpha-catenin presents a mutation, which leads to embryonic lethality, due to a lack of fetal liver hematopoiesis and severe lymphedema but no detectable defects in blood vessel formation and remodeling.

  7. alphaE-catenin recruits vinculin to adherens junctions more effectively than alphaN-catenin, partly because of its higher affinity for actin filaments.

  8. our results show that alpha-catenin-mediated cell adhesion and cell organization are important for the fissure closure in mice, and further suggest that genes that regulate cell adhesion may underlie certain coloboma cases in humans

  9. alpha-Catenin and vinculin (show VCL Proteins) cooperate to promote high E-cadherin (show CDH1 Proteins)-based adhesion strength

  10. alpha-catenin, previously implicated in tumor suppression and cell density sensing in the skin, is an upstream negative regulator of Yap1 (show YAP1 Proteins); alpha-catenin controls Yap1 (show YAP1 Proteins) activity and phosphorylation by modulating its interaction with 14-3-3 (show YWHAQ Proteins) and PP2A (show PPP2R2B Proteins) phosphatase.

Human Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) interaction partners

  1. alpha- and beta-catenins may be important in the early stages of phyllodes tumours development, while E-cadherin (show CDH1 Proteins) may be required for malignant development

  2. This work identified alpha-catenin as another molecule in addition to E- and P-cadherin that were targeted to inactivate homotypic cell-in-cell structures formation in human tumor cells.

  3. Progressive loss of e-cadherin (show CDH1 Proteins)/alpha-catenin expression is associated with an aggressive phenotype (low differentiation, increased metastatic activity/advanced stage) in thyroid carcinomas.

  4. study identifies CTNNA1 gene variants as a cause of macular dystrophy, indicates that CTNNA1 is involved in maintaining RPE (show RPE Proteins) integrity

  5. The results demonstrate a Fas (show FAS Proteins)-mediated apoptotic signaling pathway that is enhanced by the age-dependent loss of alpha(E)-catenin in renal tubule epithelial cells.

  6. Actin-dependent CTNNA1 clustering is a unique molecular mechanism mediating both integrity and reassembly of the cell-cell adhesive interface formed through weak cis (show CISH Proteins)- and trans-intercadherin interactions.

  7. alpha-catenin is a reversible, stretch-activatable sensor that mechanically links cadherin complexes and actin and is an indispensable player in cadherin-specific mechanotransduction at intercellular junctions.

  8. alpha-catenin functions as a tumor suppressor in E-cadherin (show CDH1 Proteins)-negative basal like breast cancer cells by inhibiting NF-kappaB (show NFKB1 Proteins) signaling.

  9. CTNNA1 hypermethylation was detected in three out of four with isolated del(5q), one with trisomy 11, one with monosomy 7, one out of four with del(20q), and one out of seven with complex abnormalities, but in none with trisomy 8.

  10. CTNNA1 methylation is a recurrent event but has no influence on prognosis in acute myeloid leukemia (show BCL11A Proteins)

Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) Protein Profile

Protein Summary

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Alternative names and synonyms associated with Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1)

  • catenin (cadherin-associated protein), alpha 1, 102kDa (CTNNA1)
  • alpha Catenin (alpha-Cat)
  • alpha Catenin (Dgrialpha-Cat)
  • catenin alpha-1 (Tsp_10127)
  • catenin (cadherin-associated protein), alpha 1, 102kDa (ctnna1)
  • catenin (cadherin associated protein), alpha 1 (Ctnna1)
  • catenin (cadherin-associated protein), alpha 1 (ctnna1)
  • catenin (cadherin-associated protein), alpha 1, 102kDa (Ctnna1)
  • catenin (cadherin-associated protein), alpha 2 (CTNNA2)
  • 2010010M04Rik protein
  • a-cat protein
  • AA517462 protein
  • AI988031 protein
  • Alpha-Cat protein
  • alpha-catenin protein
  • alpha-ctn protein
  • alphacat protein
  • CAP102 protein
  • Catna1 protein
  • CG17947 protein
  • CT39986 protein
  • ctnna protein
  • CTNNA1 protein
  • Dalpha-cat protein
  • DalphaC protein
  • Dalphacat protein
  • DgriGH19548 protein
  • dgri_GLEANR_3829 protein
  • Dmcatp protein
  • Dmel\\CG17947 protein
  • GH19548 protein

Protein level used designations for CTNNA1

CG17947-PA , D-alpha-catenin , Dalpha-Catenin , Dalpha-cadherin , DalphaCatenin , a-catenin , alpha catenin , alpha-Cat-PA , alpha-Catenin , alphaCatenin , catenin alpha 1 subunit , catenin alpha-1 , DgriGH19548-PA , Dgrialpha-Cat-PA , GH19548-PA , catenin (cadherin-associated protein), alpha 1, 102kDa , catenin alpha-1-like , 102 kDa cadherin-associated protein , CAP102 , alpha E catenin , alpha E-catenin , alpha(E)-catenin , cadherin associated protein , catenin alpha 1 , [a]E-catenin , alpha-E-catenin , alpha-catenin , alphaE-catenin , cadherin-associated protein,102kDa , renal carcinoma antigen NY-REN-13 , catenin (cadherin associated protein), alpha 1 , catenin, alpha 1

100072548 Equus caballus
40517 Drosophila melanogaster
450165 Pan troglodytes
574385 Macaca mulatta
6563215 Drosophila grimshawi
10905794 Trichinella spiralis
100020276 Monodelphis domestica
100091564 Ornithorhynchus anatinus
100407624 Callithrix jacchus
100453792 Pongo abelii
100483944 Ailuropoda melanoleuca
100538100 Danio rerio
100550456 Meleagris gallopavo
12385 Mus musculus
30741 Danio rerio
1495 Homo sapiens
474698 Canis lupus familiaris
307505 Rattus norvegicus
416184 Gallus gallus
100523778 Sus scrofa
526848 Bos taurus
100328952 Oryctolagus cuniculus
483088 Canis lupus familiaris
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