Browse our anti-FMR1 (FMR1) Antibodies

Full name:
anti-Fragile X Mental Retardation 1 Antibodies (FMR1)
On www.antibodies-online.com are 169 Fragile X Mental Retardation 1 (FMR1) Antibodies from 27 different suppliers available. Additionally we are shipping FMR1 Proteins (7) and FMR1 Kits (5) and many more products for this protein. A total of 188 FMR1 products are currently listed.
Synonyms:
AT24755, BcDNA:GM08679, cg6203, dfmr, dfmr1, dFmrp, dfxr, dfxr1, dFXRP, Dmel\\CG6203, dmfr1, EP(3)3517, fmr, Fmr-1, fmr1, Fmrp, FRAXA, FXR, POF, POF1, zFMR1
list all antibodies Gene Name GeneID UniProt
FMR1 2332 Q06787
FMR1 24948 Q80WE1
FMR1 14265  

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Top referenced anti-FMR1 Antibodies

  1. Fruit Fly (Drosophila melanogaster) Monoclonal FMR1 Primary Antibody for ICC, IF - ABIN108599 : Wan, Dockendorff, Jongens, Dreyfuss: Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. in Molecular and cellular biology 2000 (PubMed)
    Show all 7 references for 108599

  2. Bat Polyclonal FMR1 Primary Antibody for WB - ABIN610747 : Anderson, Teutsch, Dong, Wortis: An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 2 references for 610747

  3. Human Polyclonal FMR1 Primary Antibody for ELISA, IHC (p) - ABIN451678 : Hanson, Blank, Valenzuela, Garner, Madison: The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. in The Journal of physiology 2007 (PubMed)

  4. Human Polyclonal FMR1 Primary Antibody for FACS, IHC (p) - ABIN390866 : Yuhas, Walichiewicz, Pan, Zhang, Casillas, Hagerman, Tassone: High-risk fragile x screening in Guatemala: use of a new blood spot polymerase chain reaction technique. in Genetic testing and molecular biomarkers 2009 (PubMed)

  5. Human Polyclonal FMR1 Primary Antibody for ELISA, WB - ABIN4312232 : Dölen, Osterweil, Rao, Smith, Auerbach, Chattarji, Bear: Correction of fragile X syndrome in mice. in Neuron 2007 (PubMed)

  6. Human Polyclonal FMR1 Primary Antibody for ICC, IF - ABIN443330 : Zhang, Brown, Hyland, Chen, Kronengold, Fleming, Kohn, Moroz, Kaczmarek: Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 (PubMed)

More Antibodies against FMR1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. Fmr1 protein associates with ninaE (show RHO Antibodies) mRNA and represses its translation.

  2. Our data strongly support a gain-of-function pathogenic mechanism of PQBP1 (show PQBP1 Antibodies) c.459_462delAGAG and c.463_464dupAG mutations, and suggest that therapeutic strategies to restore FMRP function may be beneficial for those patients

  3. dFMRP cooperates with Piwi in maintaining genome integrity by silencing heterochromatic genes and suppressing transposon expression.

  4. results show Fragile X Mental Retardation Protein (FMRP) shapes neuron class-specific calcium signaling in excitatory vs. inhibitory neurons in developing learning/memory circuitry, and that FMRP mediates activity-dependent regulation of calcium signaling specifically during the early-use critical period.

  5. results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 (show TARDBP Antibodies) overexpression

  6. demonstrate that Zfrp8 genetically interacts with Fmr1 and tral (show LSM14A Antibodies) in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways

  7. dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart.

  8. These results show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical period development of learning and memory circuitry in the Drosophila brain.

  9. upon the stimulation of replication stress, dFMR1 is associated with chromatin in a domain-specific manner, which is essential for its ability to induce the phosphorylation of H2Av (show H2AFV Antibodies).

  10. FMRP inhibits translation by binding directly to the L5 protein on the 80S ribosome.

Human Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. Intragenic FMR1 variants, although much less frequent than CGG expansions, are a significant mutational mechanism leading to FXS.

  2. FMR1 triple CGG repeats in the normal range may be associated with primary ovarian insufficiency in China

  3. Expression of FMRpolyG is pathogenic, while the sole expression of CGG RNA is not. FMRpolyG interacts with the nuclear lamina protein LAP2beta (show TMPO Antibodies) and disorganizes the nuclear lamina architecture in neurons differentiated from FXTAS iPS (show SLC27A4 Antibodies) cells. Finally, expression of LAP2beta (show TMPO Antibodies) rescues neuronal death induced by FMRpolyG.

  4. FMR1 CGG trinucleotide repeats were low in Caucasian women with diminished ovarian reserve.

  5. For routine screening of patients/carriers with full/pre-mutations of the FMR1 gene in the population.

  6. Data show that the FMRP deficiency in fragile X syndrome (FXS) patients has significant impact on the gene expression patterns during development, which will help to discover potential targeting candidates for the cure of FXS symptoms.

  7. FMRP plays a role regulating mRNAs during pivotal maturational processes in fetal germ cells, and ovarian dysfunction resulting from FMR1 premutation may have its origins during these stages of oocyte development.

  8. Social anxiety is more frequent in females with the fragile X mental retardation 1 protein (FMR1) premutation than in controls, but not in males.

  9. Study provides evidence linking white matter microstructure to executive dysfunction and elevated FMR1 mRNA and FMR1 exon 1/intron 1 boundary methylation in women with a FMR1 premutation expansion without fragile X-associated tremor/ataxia (show USP14 Antibodies) syndrome

  10. a shared dataset of FMRP consensus binding sequences (FCBS), which were reproducibly identified in two published FMRP CLIP sequencing datasets.

Zebrafish Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. We identified thousands of clustered RNA editing sites in the zebrafish transcriptome and showed that Fmrp biochemically interacts with the Adar2a protein. The expression levels of the adar (show ADAR Antibodies) genes and Adar2 (show ADARB1 Antibodies) protein increased in fmr1-/- zebrafish

  2. Loss-of-function fmr1 mutants carrying an anti-fmr1 miRNA transgene show abnormal neuronal morphology and connectivity similar to that seen in human fragile X syndrome.

Mouse (Murine) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. FMRP mediates structural plasticity of olfactory bulb adult-born neurons to support olfactory learning through alphaCaMKII local translation.

  2. This study demonstrated that astrocyte-specific Fmr1 conditional knock-out and restoration mice, and provided compelling evidence that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS.

  3. FMRP is involved in pri-miRNA processing via enhancing DROSHA (show DROSHA Antibodies) expression that may play an important role in fragile X syndrome.

  4. FMRP is likely to participate in retinal physiology, since its expression changes with light exposure. In addition, the expression pattern and regulation by light of FMRP seems well conserved since it was similar in both mouse and chick.

  5. Male offspring of Fmr1+/- mothers, independent of their own Fmr1 genotype, exhibit social behavior abnormality.

  6. This study demonstrated that alterations in intrinsic properties in individual neurons are involved in the abnormal excitability of cortical circuitry in Fmr-1 knockout mice.

  7. One third of the putative mRNA targets described for FMRP appear to be transported in granules and FMRP is more abundant in granules than in polyribosomes. This observation supports a primary role for FMRP in granules biology.

  8. Study showed that Fmr1 knock-out astrocytes affect the dendritic arborization of all subtypes of hippocampal neurons and that select populations of hippocampal neurons are more effected by this astrocyte-mediated developmental delay; specifically, the stellate neurons grown on Fmr1 knock-out astrocytes exhibit the most pervasive developmental delays

  9. The data reveal an age-dependent deficit in long-term potentiation in Fmr1KO mice, which may correlate to some of the complex age-related deficits in Fragile X syndrome.

  10. increased white matter seen in the FMR1-KO-FVB could be highlighting a structural over-connectivity, which could lead to some of the behavioral abnormalities seen with the FMR1-KO-FVB mice

FMR1 Antigen Profile

Antigen Summary

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

Alternative names and synonyms associated with FMR1

  • CG6203 gene product from transcript CG6203-RC (Fmr1) antibody
  • fragile X mental retardation 1 (FMR1) antibody
  • fragile X mental retardation 1 (Fmr1) antibody
  • fragile X mental retardation 1 (fmr1) antibody
  • fragile X mental retardation syndrome 1 (Fmr1) antibody
  • AT24755 antibody
  • BcDNA:GM08679 antibody
  • cg6203 antibody
  • dfmr antibody
  • dfmr1 antibody
  • dFmrp antibody
  • dfxr antibody
  • dfxr1 antibody
  • dFXRP antibody
  • Dmel\\CG6203 antibody
  • dmfr1 antibody
  • EP(3)3517 antibody
  • fmr antibody
  • Fmr-1 antibody
  • fmr1 antibody
  • Fmrp antibody
  • FRAXA antibody
  • FXR antibody
  • POF antibody
  • POF1 antibody
  • zFMR1 antibody

Protein level used designations for FMR1

CG6203-PA , CG6203-PB , CG6203-PC , CG6203-PD , CG6203-PE , CG6203-PF , CG6203-PG , CG6203-PH , CG6203-PI , Fmr1-PA , Fmr1-PB , Fmr1-PC , Fmr1-PD , Fmr1-PE , Fmr1-PF , Fmr1-PG , Fmr1-PH , Fmr1-PI , Fragile-X mental retardation protein , Fragile-X-related , dFmr1 , drosophila fragile X mental retardation protein , fragile X , fragile X mental retardation , fragile X mental retardation 1 , fragile X mental retardation gene , fragile X mental retardation protein , fragile X protein , fragile X related protein , fragile X-related , fragile x related , fragile-X , fragile X mental retardation protein 1 , fragile X mental retardation protein 1 homolog , fragile X mental retardation syndrome 1 homolog , fragile X mental retardation-1 protein , protein FMR-1 , ragile X mental retardation protein , fragile X mental retardation 1 protein , FMRP , mFmr1p

GENE ID SPECIES
37528 Drosophila melanogaster
465894 Pan troglodytes
2332 Homo sapiens
481070 Canis lupus familiaris
24948 Rattus norvegicus
259191 Danio rerio
422395 Gallus gallus
100155078 Sus scrofa
507482 Bos taurus
100172902 Pongo abelii
14265 Mus musculus
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