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anti-Human DROSHA Antibodies:
anti-Mouse (Murine) DROSHA Antibodies:
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Human Polyclonal DROSHA Primary Antibody for ICC, IF - ABIN315874
Hsieh, Lin, Liu, Chang, Shih, Zhong, Lee, Tan: WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway. in Nucleic acids research 2011
Show all 5 Pubmed References
Human Polyclonal DROSHA Primary Antibody for ELISA, WB - ABIN188686
Thomson, Newman, Parker, Morin-Kensicki, Wright, Hammond: Extensive post-transcriptional regulation of microRNAs and its implications for cancer. in Genes & development 2006
Mechanistic dissection reveals that NEAT1 broadly interacts with the NONO (show NONO Antibodies)-PSF (show IGFBP7 Antibodies) heterodimer as well as many other RNA-binding proteins and that multiple RNA segments in NEAT1, including a 'pseudo pri-miRNA' near its 3' end, help attract the Drosha-DGCR8 (show DGCR8 Antibodies) Microprocessor.
Results show that Mammalian DROSHA genes have evolved a conserved hairpin structure spanning a specific exon-intron junction serving as a substrate for the microprocessor in human but not in murine cells. This hairpin element decides whether the overlapping exon is alternatively or constitutively spliced. Also, DROSHA promotes skipping of the overlapping exon in human cells independently of its cleavage function.
Report DROSHAnumerous processing sites on primary microRNAs and noncanonical substrates which may serve as cis (show CISH Antibodies)-elements for DROSHA-mediated gene regulation.
HPV E6/E7 increased expression of DROSHA and DICER (show DICER1 Antibodies) mRNA and protein in cervical carcinoma cells.
Knockdown of Drosha, the apoptosis rate of MGC-803 cells was increased, the protein expressions of caspase-3 (show CASP3 Antibodies) , caspase-9 (show CASP9 Antibodies) and Bax (show BAX Antibodies) were significantly upregulated and Bcl-2 (show BCL2 Antibodies) was downregulated.
The rs417309 and rs1640299 polymorphisms of the DGCR8 (show DGCR8 Antibodies) gene as well as rs6877842 of the DROSHA gene might be associated with a risk of laryngeal cancer occurrence in the Polish population.
miR (show MLXIP Antibodies)-27b mimics, DROSHA siRNA, and miR (show MLXIP Antibodies)-27b inhibitors to verify the negative regulatory relationship between MiR (show MLXIP Antibodies)-27b and DROSHA. The presence of rs10719 disrupted the interaction between miR (show MLXIP Antibodies)-27b and DROSHA, which might be the underlying mechanism of the observation that rs10719 is significantly associated with risk of primary hypertension.
For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 (show ESR1 Antibodies) rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 (show ZCCHC11 Antibodies) rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR (show MLXIP Antibodies)-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s
Drosha and DGRC8 were significantly downregulated in healthy-appearing perilesional skin from hidradenitis suppurativa patients compared to healthy controls.
Authors found that DENV4 infection exhibited the highest viral load 3 days post-infection. Dicer (show DICER1 Antibodies), Drosha, and DGCR8 (show DGCR8 Antibodies) showed reduced expression following DENV4 infection as compared with negative controls.
Identification of Microprocessor component DROSHA as a novel DNMT1 (show DNMT1 Antibodies)-interactor.
Results show that Mammalian DROSHA genes have evolved a conserved hairpin structure spanning a specific exon-intron junction serving as a substrate for the microprocessor in human but not in murine cells.
Knockdown of NFIB (show NFIB Antibodies) in Drosha-deficient hippocampal neural stem cells restores neurogenesis, suggesting that the Drosha/NFIB (show NFIB Antibodies) mechanism robustly prevents oligodendrocyte fate acquisition in vivo.
FMRP (show FMR1 Antibodies) is involved in pri-miRNA processing via enhancing DROSHA expression that may play an important role in fragile X (show FMR1 Antibodies) syndrome.
our findings suggest that DROSHA is involved in stromal decidualization and may play an important role in embryo implantation in mice.
These data indicate that oocyte DICER (show DICER1 Antibodies) expression in the fetal ovary is required, and oocyte DROSHA is dispensable, for postnatal follicular development and female fertility in adulthood.
Drosha repressed the expression of two mRNAs encoding inhibitors of myelopoiesis in early hematopoietic progenitors.
Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.
Data indicate that Arf-deficient cells transformed by oncogenic Ras were dependent on increased Drosha expression as Drosha knockdown was sufficient to inhibit Ras-dependent cellular transformation.
Drosha is required for VSMC survival by targeting multiple signaling pathways.
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002
, ribonuclease 3
, Ribonuclease 3
, RNase III
, drosha, double-stranded RNA-specific endoribonuclease
, nuclear RNase III Drosha
, protein Drosha
, putative protein p241 which interacts with transcription factor Sp1
, putative ribonuclease III
, ribonuclease III, nuclear
, ribonuclease type III, nuclear
, ethanol induced 2