DROSHA antibody
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- Target See all DROSHA Antibodies
- DROSHA (Drosha, Ribonuclease Type III (DROSHA))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DROSHA antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogen
- A synthetic peptide of human DROSHA (NP_037367.3).
- Isotype
- IgG
- Top Product
- Discover our top product DROSHA Primary Antibody
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- Application Notes
- WB 1:500-1:2000 IF 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- DROSHA (Drosha, Ribonuclease Type III (DROSHA))
- Alternative Name
- DROSHA (DROSHA Products)
- Synonyms
- im:7150667 antibody, zgc:158612 antibody, ETOHI2 antibody, HSA242976 antibody, RANSE3L antibody, RN3 antibody, RNASE3L antibody, RNASEN antibody, 1110013A17Rik antibody, AI874853 antibody, Etohi2 antibody, Rn3 antibody, Rnasen antibody, RGD1307626 antibody, ribonuclease type III, nuclear antibody, Ribonuclease 3 antibody, ribonuclease 3 antibody, drosha ribonuclease III antibody, drosha, ribonuclease type III antibody, rnasen antibody, Thicy_0885 antibody, Sinme_0866 antibody, Isova_2087 antibody, Sphch_0770 antibody, DROSHA antibody, Drosha antibody
- Background
- This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.
- Molecular Weight
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Observed_MW: 180 kDa
Calculated_MW: 138 kDa/151 kDa/155 kDa/159 kDa
- Gene ID
- 29102
- UniProt
- Q9NRR4
- Pathways
- Regulatory RNA Pathways
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