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Browse our FAK Proteins (PTK2)

Full name:
PTK2 Protein tyrosine Kinase 2 Proteins (PTK2)
On www.antibodies-online.com are 16 PTK2 Protein tyrosine Kinase 2 (PTK2) Proteins from 8 different suppliers available. Additionally we are shipping FAK Antibodies (679) and FAK Kits (31) and many more products for this protein. A total of 753 FAK products are currently listed.
Synonyms:
Fadk, FAK, FAK1, FRNK, mKIAA4203, p125FAK, pp125FAK, PPP1R71
list all proteins Gene Name GeneID UniProt
PTK2 5747 Q05397
PTK2 25614 O35346
PTK2 14083 P34152

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FAK Proteins (PTK2) by Origin

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Top referenced FAK Proteins

  1. Human FAK Protein expressed in HEK-293 Cells - ABIN2720714 : Banerjee, de Freitas, Friggeri, Zmijewski, Liu, Abraham: Intracellular HMGB1 negatively regulates efferocytosis. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)

More Proteins for FAK Interaction Partners

Human PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. SMARCE1 (show SMARCE1 Proteins) plays an essential role in breast cancer metastasis by protecting cells against anoikis through the HIF1A (show HIF1A Proteins)/PTK2 pathway.

  2. Data show that p63 transcription factors modulate cell migration via Src-focal adhesion kinase (FAK) signaling in foreskin keratinocytes (HFK) expressing human papilloma virus (HPV)16 E6/E7 genes.

  3. Focal adhesion kinase expression predicts neoadjuvant Chemoradiation response in rectal cancer patients

  4. FAK is tightly associated with H3K9 methylation and negatively related to the growth of tumor-repopulating cells.

  5. FAK plays a key role in regulating macrophage behavior, which underlies the chronic progression of abdominal aortic aneurysms.

  6. No associations between PTK2 SNP and skeletal muscle specific (show EIF3K Proteins) force were observed.

  7. FAK kinase activity is important in promoting influenza A virus subtypes replication by regulating its polymerase activity.

  8. Mono treatment with lexatumumab was not sufficient to induce apoptosis in pancreatic cancer cells, whereas focal adhesion kinase inhibitor PF573228 significantly sensitized lexatumumab-induced apoptosis. Western blotting analysis revealed that lexatumumab and PF573228 combination treatment increased death receptor 5 (show TNFRSF10B Proteins) but decreased Bcl-xL (show BCL2L1 Proteins) expression. sed the ins (show INS Proteins)

  9. NF2 (show NF2 Proteins) regulates the interaction of FAK-p53 (show TP53 Proteins) and MDM2 (show MDM2 Proteins)-p53 (show TP53 Proteins).

  10. These data provide insight into the mechanisms guiding PRL (show PRL Proteins)-mediated breast cancer cell motility and invasion and highlight a significant role for phosphoTyr-PAK1 (show PAK1 Proteins) in breast cancer metastasis.

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. evidence that despite the fact that FAK is in the active, open conformation at CAs (show CSE1L Proteins), its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.

  2. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  3. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  4. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  5. These data suggest an important role for the FERM domain in the activation of FAK.

  6. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF Proteins), while phosphorylation at Y925 controls the rate of point contact turnover.

  7. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  8. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. identify FAK as a novel negative regulator of Beclin1 (show BECN1 Proteins)-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth

  2. FAK is tightly associated with H3K9 methylation and negatively related to the growth of tumor-repopulating cells.

  3. FAK plays a key role in regulating macrophage behavior, which underlies the chronic progression of abdominal aortic aneurysms.

  4. FAK sustained the active integrin conformation by maintaining talin association with Rab11 endosomes in a type I phosphatidylinositol phosphate kinase (PIPKIgamma)-dependent manner.

  5. FAK promotes nascent integrin adhesions (NA) assembly and timely turnover to couple lamellipodial protrusion to adhesions for efficient advance of the leading edge. Phosphorylation on Y397 of FAK promotes dense NA formation but is dispensable for transient NA stabilization and leading edge advance.

  6. this manuscript shows that endothelial cell FAK activity induces VCAM-1 (show VCAM1 Proteins) expression and contributes to atherosclerosis

  7. FAK activation is necessary for the promotion of osteogenesis induced by extracorporeal shockwave.

  8. Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.

  9. results suggest that LPS (show TLR4 Proteins)-stimulated macrophage mediators attenuate both FAK and Src (show SRC Proteins) activations in osteoblast, suggesting a novel role for TNFalpha (show TNF Proteins) on osteoblast performance

  10. Report phosphorylation sites in focal adhesion kinase and putative new binding partners.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. RhoA (show RHOA Proteins) and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK activation in response to shear stress.

  2. XIAP (show XIAP Proteins) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C

  4. These results suggest that TGF-beta1 (show TGFB1 Proteins)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC Proteins)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 Proteins)-induced vascular smooth muscle cell migration.

FAK (PTK2) Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Alternative names and synonyms associated with FAK (PTK2)

  • PTK2 protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (Ptk2)
  • protein tyrosine kinase 2 (ptk2)
  • PTK2 protein tyrosine kinase 2 (Ptk2)
  • Fadk protein
  • FAK protein
  • FAK1 protein
  • FRNK protein
  • mKIAA4203 protein
  • p125FAK protein
  • pp125FAK protein
  • PPP1R71 protein

Protein level used designations for PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

GENE ID SPECIES
100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
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