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Browse our FAK Proteins (PTK2)

Full name:
PTK2 Protein tyrosine Kinase 2 Proteins (PTK2)
On are 15 PTK2 Protein tyrosine Kinase 2 (PTK2) Proteins from 8 different suppliers available. Additionally we are shipping FAK Antibodies (709) and FAK Kits (30) and many more products for this protein. A total of 778 FAK products are currently listed.
Fadk, FAK, FAK1, FRNK, mKIAA4203, p125FAK, pp125FAK, PPP1R71
list all proteins Gene Name GeneID UniProt
PTK2 5747 Q05397
PTK2 25614 O35346
PTK2 14083 P34152

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FAK Proteins (PTK2) by Origin

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Top referenced FAK Proteins

  1. Human FAK Protein expressed in Human - ABIN2720714 : Banerjee, de Freitas, Friggeri, Zmijewski, Liu, Abraham: Intracellular HMGB1 negatively regulates efferocytosis. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)

More Proteins for FAK Interaction Partners

Human PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK/SRC (show SRC Proteins) and paxillin (show PXN Proteins) play a role in the pathophysiological aspects of mobile tongue squamous cell carcinoma and could constitute therapeutic targets

  2. RNA interference effectively silences FAK expression and inhibits malignant cell proliferation and invasion in gastric cancer cells.

  3. Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 (show RBL2 Proteins) Crk-associated substrate (CAS (show BCAR1 Proteins)) was found to be correlated with pancreatic cancer cell invasiveness.

  4. Focal adhesion kinase-sortilin (show SORT1 Proteins) interactions have an important role in colorectal cancer cells dissociation. (Review)

  5. both UFH and LMWH, through a FAK/actin cytoskeleton axis, promoted the adhesion and migration of B6FS fibrosarcoma cells

  6. AURKA (show AURKA Proteins) may induce EMT (show ITK Proteins) to promote metastasis via activation of the FAK/PI3K (show PIK3CA Proteins) pathway in LSCC.

  7. Lunasin suppresses the metastasis of breast cancer cells through integrin-mediated FAK/Akt (show AKT1 Proteins)/ERK (show EPHB2 Proteins) and NF-kappaB (show NFKB1 Proteins) signaling pathways followed by downregulation of the activity and expression of MMP-2 (show MMP2 Proteins)/-9.

  8. FAK and FAK[pY397] were overexpressed in human UM tumors compared to normal ocular tissue and high levels of FAK[pY397] were seen in the most aggressive UM cell lines.

  9. Upregulated expression of FAK is associated with hepatocellular carcinoma.

  10. ITGB4 (show ITGB4 Proteins) is overexpressed in hepatocellular carcinoma tissues and promotes metastases of HCC (show FAM126A Proteins) by conferring anchorage independence through EGFR (show EGFR Proteins)-dependent FAK-AKT (show AKT1 Proteins) activation.

Xenopus laevis PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex.

  2. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.

  3. work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development

  4. These data suggest an important role for the FERM domain in the activation of FAK.

  5. FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF (show BDNF Proteins), while phosphorylation at Y925 controls the rate of point contact turnover.

  6. Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis.

  7. FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins.

Mouse (Murine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. FAK promotes nascent integrin adhesions (NA) assembly and timely turnover to couple lamellipodial protrusion to adhesions for efficient advance of the leading edge. Phosphorylation on Y397 of FAK promotes dense NA formation but is dispensable for transient NA stabilization and leading edge advance.

  2. this manuscript shows that endothelial cell FAK activity induces VCAM-1 (show VCAM1 Proteins) expression and contributes to atherosclerosis

  3. FAK activation is necessary for the promotion of osteogenesis induced by extracorporeal shockwave.

  4. Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.

  5. results suggest that LPS (show TLR4 Proteins)-stimulated macrophage mediators attenuate both FAK and Src (show SRC Proteins) activations in osteoblast, suggesting a novel role for TNFalpha (show TNF Proteins) on osteoblast performance

  6. Report phosphorylation sites in focal adhesion kinase and putative new binding partners.

  7. data indicate that PTPalpha (show PTPRA Proteins) and FAK, which are enriched in FAs (show FAS Proteins), interact with IP3R1 (show ITPR1 Proteins) at adjacent ER sites to spatially sequester IL-1 (show IL1A Proteins)-induced Ca(2 (show CA2 Proteins)+) signalling

  8. FAK-regulated signalling module PDK1 (show PDPK1 Proteins)-Akt (show AKT1 Proteins)-p70S6K (show RPS6KB1 Proteins) that controls Src's intracellular trafficking operates at Src (show SRC Proteins)-containing autophagosomes.

  9. Data show that active active focal adhesion kinase (FAK) localizes to integrin-containing endosomes.

  10. FAK deletion correlates with increased phosphorylation of Tks-5 (tyrosine kinase substrate with five SH3 domain) and reactive oxygen species production.

Cow (Bovine) PTK2 Protein tyrosine Kinase 2 (PTK2) interaction partners

  1. RhoA (show RHOA Proteins) and membrane fluidity mediates the spatially polarized Src (show SRC Proteins)/FAK activation in response to shear stress.

  2. XIAP (show XIAP Proteins) plays an essential role in shear stress-stimulated FAK phosphorylation.

  3. mitochondrial oxidants generated in response to endothelial strain trigger FAK phosphorylation through a signaling pathway that involves protein kinase C

  4. These results suggest that TGF-beta1 (show TGFB1 Proteins)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src (show SRC Proteins)-dependent and -independent pathways.

  5. Results suggest focal adhesion kinase is involved in thrombospondin-1 (show THBS1 Proteins)-induced vascular smooth muscle cell migration.

FAK (PTK2) Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Alternative names and synonyms associated with FAK (PTK2)

  • PTK2 protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (PTK2)
  • protein tyrosine kinase 2 (Ptk2)
  • protein tyrosine kinase 2 (ptk2)
  • PTK2 protein tyrosine kinase 2 (Ptk2)
  • Fadk protein
  • FAK protein
  • FAK1 protein
  • FRNK protein
  • mKIAA4203 protein
  • p125FAK protein
  • pp125FAK protein
  • PPP1R71 protein

Protein level used designations for PTK2

FADK 1 , FAK-related non-kinase polypeptide , PTK2 protein tyrosine kinase 2 , focal adhesion kinase 1 , focal adhesion kinase-related nonkinase , protein phosphatase 1 regulatory subunit 71 , protein phosphatase 1, regulatory subunit 71 , pp125FAK , protein-tyrosine kinase 2 , focal adhesion kinase pp125FAK , focal ashension kinase 1 , p41/p43FRNK , focal adhesion kinase

100058245 Equus caballus
5747 Homo sapiens
25614 Rattus norvegicus
399286 Xenopus laevis
14083 Mus musculus
396416 Gallus gallus
475108 Canis lupus familiaris
506270 Bos taurus
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