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a novel pathway of CSTA regulation involving Dsg2 (show DSG2 Proteins)
analysis of a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1
The results suggest that C12orf39, CSTA, and CALCB (show CALCB Proteins) are novel ATF4 (show ATF4 Proteins) target genes, and that C12orf39 promoter activity is activated by ATF4 (show ATF4 Proteins) through amino acid response element.
CSTA/TYROBP (show TYROBP Proteins) gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis .
High expression of stefin A may be an important factor contributing to the development and metastasis of Hepatocellular Carcinoma.
Both MIP-3alpha (show CCL20 Proteins) and cystatin A overexpressions in NPC (show NPC1 Proteins) tumor tissues were strong independent factors of poor prognosis in NPC (show NPC1 Proteins) patients.
We identified a homozygous nonsense mutation (p.Lys22X) in the CSTA gene in acral peeling skin syndrome.
Data indicate that desmoplakin (DSP) and cystatin A (CSTA) interaction and insulin-like growth factor 1 (IGF-1 (show IGF1 Proteins)), IGF-binding protein 7 (IGFBP7 (show IGFBP7 Proteins)) and syndecan 1 (SDC1 (show SDC1 Proteins)) interaction were observed in protein-protein interaction (PPI) network.
Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway
findings provide a new molecular understanding of the mechanisms of MYOC (show MYOC Proteins)-causative glaucoma and reveal CSTA, a serum biomarker for cancer, as a potential biomarker and drug for the treatment of MYOC (show MYOC Proteins)-induced glaucoma
study identified loss-of-function mutations in the gene for protease inhibitor cystatin A as the underlying genetic cause of exfoliative ichthyosis (show LBR Proteins)
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.
cystatin A (stefin A)
, cystatin AS
, stefin A
, epidermal stefin
, epidermal thiol proteinase inhibitor