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Browse our anti-ASXL1 (ASXL1) Antibodies

Full name:
anti-Additional Sex Combs Like 1 (Drosophila) Antibodies (ASXL1)
On are 34 Additional Sex Combs Like 1 (Drosophila) (ASXL1) Antibodies from 12 different suppliers available. Additionally we are shipping ASXL1 Proteins (5) and many more products for this protein. A total of 40 ASXL1 products are currently listed.
asxl1, BOPS, MDS, MGC83850, mKIAA0978
list all antibodies Gene Name GeneID UniProt
ASXL1 228790 P59598
ASXL1 171023 Q8IXJ9

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Most Popular Reactivities for anti-ASXL1 (ASXL1) Antibodies

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anti-Mouse (Murine) ASXL1 Antibodies:

anti-Human ASXL1 Antibodies:

anti-Rat (Rattus) ASXL1 Antibodies:

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Top referenced anti-ASXL1 Antibodies

  1. Human Polyclonal ASXL1 Primary Antibody for EIA, FACS - ABIN950543 : Abdel-Wahab, Kilpivaara, Patel, Busque, Levine: The most commonly reported variant in ASXL1 (c.1934dupG;p.Gly646TrpfsX12) is not a somatic alteration. in Leukemia 2010 (PubMed)
    Show all 4 references for ABIN950543

  2. Human Polyclonal ASXL1 Primary Antibody for IHC - ABIN965603 : Fisher, Berger, Randazzo, Brock: A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11. in Gene 2003 (PubMed)

  3. Human Monoclonal ASXL1 Primary Antibody for ELISA, WB - ABIN949894 : Davies, Yip, Fernandez-Mercado, Woll, Agirre, Prosper, Jacobsen, Wainscoat, Pellagatti, Boultwood: Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34? progenitor cells. in British journal of haematology 2013 (PubMed)

  4. Mouse (Murine) Polyclonal ASXL1 Primary Antibody for FACS, IF - ABIN655084 : Rocquain, Carbuccia, Trouplin, Raynaud, Murati, Nezri, Tadrist, Olschwang, Vey, Birnbaum, Gelsi-Boyer, Mozziconacci: Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. in BMC cancer 2010 (PubMed)

More Antibodies against ASXL1 Interaction Partners

Mouse (Murine) Additional Sex Combs Like 1 (Drosophila) (ASXL1) interaction partners

  1. implicate Asxl1 in the maintenance of podocyte structure via its association with Wtip (show WTIP Antibodies) and in the regulation of WT1 (show WT1 Antibodies) signaling during early kidney development

  2. ASXL1 truncation mutations confer gain-of-function on the ASXL-BAP1 (show BAP1 Antibodies) complex.

  3. Asxl1-/- fetuses have reduced body weight and display cleft palate, anophthalmia as well as ventricular septal defects and a failure in lung maturation.

  4. Asxl1 functions as a tumor suppressor to maintain hematopoietic cell homeostasis

  5. C-terminal-truncating Asxl1 mutations inhibited myeloid differentiation and induced myelodysplastic syndrome-like disease

  6. Constitutive loss of Asxl1 results in developmental abnormalities, including anophthalmia, microcephaly, cleft palate, and mandibular malformations. Hematopoietic-specific deletion results in cytopenia and dysplasia with increased hematopoietic stem cells

  7. ASXL1 represses, whereas ASXL2 (show ASXL2 Antibodies) increases, the expression of adipogenic genes, most of which are PPARgamma (show PPARG Antibodies) targets

  8. Asxl1 is needed for normal hematopoiesis.

  9. Asxl1and Asxl2 (show ASXL2 Antibodies) are expressed as multiple transcripts, at varying levels, in adult tissues and in embryonic stem cells analyzed by Northern blot, and exhibit similar expression patterns suggesting they may be co-regulated

  10. ASXL1 is a novel coactivator of RAR (show RARA Antibodies) that cooperates with SRC-1 (show NCOA1 Antibodies)

Human Additional Sex Combs Like 1 (Drosophila) (ASXL1) interaction partners

  1. Mutations in ASXL1, U2AF1 (show U2AF1 Antibodies), and SF3B1 (show SF3B2 Antibodies) are common in Chinese patients with myelodysplastic syndromes.

  2. ASXL1 germline missense substitution is associated with hematological malignancies.

  3. identified significant ASXL1 SNPs in Chinese patients with acquired aplastic anemia (AA); results showed 8.2% had the recurrent conjoined rs62206933, rs117901891 and rs74638057 genotype (WT1 (show WT1 Antibodies)), which was closely associated with poor prognosis in patients with nonsevere AA and had a greater risk of transformation to myelodysplastic syndrome

  4. Correction of ASXL1 driver mutation in leukemia cells using CRISPR/Cas (show CSE1L Antibodies) increases survival in vivo in mice.

  5. We confirm the negative prognostic impact imparted by ASXL1 mutations and suggest a favorable impact from TET2 (show TET2 Antibodies) mutations in the absence of ASXL1 mutations.

  6. Frameshift mutation in the ASXL1 gene is associated with Bohring-Opitz syndrome.

  7. De novo mutation in ASXL1 gene is associated with Bohring-Opitz syndrome.

  8. Tumor suppressor ASXL1 is essential for the activation of INK4B (show CDKN2B Antibodies) expression in response to oncogene (show RAB1A Antibodies) activity and anti-proliferative signals

  9. the present results indicate that the truncating ASXL1 mutant is indeed expressed in MDS (show PAFAH1B1 Antibodies) cells and may play a role in MDS (show PAFAH1B1 Antibodies) pathogenesis not previously considered.

  10. Chronic myelomonocytic leukemia has an inherent tendency to transform to acute myeloid leukemia (show BCL11A Antibodies). Gene mutations involving ASXL1 are frequent and identified to have an independent negative prognostic effect on overall survival.

ASXL1 Antigen Profile

Antigen Summary

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with ASXL1

  • additional sex combs like 1 (Drosophila) (asxl1) antibody
  • additional sex combs like 1 (LOC100341931) antibody
  • additional sex combs like 1 (asxl1) antibody
  • additional sex combs like 1 (Asxl1) antibody
  • additional sex combs like 1 (Drosophila) (ASXL1) antibody
  • asxl1 antibody
  • BOPS antibody
  • MDS antibody
  • MGC83850 antibody
  • mKIAA0978 antibody

Protein level used designations for ASXL1

additional sex combs like 1 , additional sex combs-like protein 1 , putative Polycomb group protein ASXL1

446414 Xenopus laevis
100341931 Oryctolagus cuniculus
100379981 Xenopus (Silurana) tropicalis
228790 Mus musculus
171023 Homo sapiens
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