Browse our anti-ASXL1 (ASXL1) Antibodies

Full name:
anti-Additional Sex Combs Like 1 (Drosophila) Antibodies (ASXL1)
On are 36 Additional Sex Combs Like 1 (Drosophila) (ASXL1) Antibodies from 12 different suppliers available. Additionally we are shipping ASXL1 Proteins (6) and many more products for this protein. A total of 43 ASXL1 products are currently listed.
asxl1, BOPS, MDS, MGC83850, mKIAA0978
list all antibodies Gene Name GeneID UniProt
ASXL1 228790 P59598
ASXL1 171023 Q8IXJ9

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Most Popular Reactivities for anti-ASXL1 (ASXL1) Antibodies

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anti-Mouse (Murine) ASXL1 Antibodies:

anti-Human ASXL1 Antibodies:

anti-Rat (Rattus) ASXL1 Antibodies:

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Top referenced anti-ASXL1 Antibodies

  1. Human Polyclonal ASXL1 Primary Antibody for EIA, FACS - ABIN950543 : Abdel-Wahab, Kilpivaara, Patel, Busque, Levine: The most commonly reported variant in ASXL1 (c.1934dupG;p.Gly646TrpfsX12) is not a somatic alteration. in Leukemia 2010 (PubMed)
    Show all 4 references for 950543

  2. Human Polyclonal ASXL1 Primary Antibody for IHC - ABIN965603 : Fisher, Berger, Randazzo, Brock: A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11. in Gene 2003 (PubMed)

  3. Human Monoclonal ASXL1 Primary Antibody for ELISA, WB - ABIN949894 : Davies, Yip, Fernandez-Mercado, Woll, Agirre, Prosper, Jacobsen, Wainscoat, Pellagatti, Boultwood: Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34? progenitor cells. in British journal of haematology 2013 (PubMed)

  4. Mouse (Murine) Polyclonal ASXL1 Primary Antibody for FACS, IF - ABIN655084 : Rocquain, Carbuccia, Trouplin, Raynaud, Murati, Nezri, Tadrist, Olschwang, Vey, Birnbaum, Gelsi-Boyer, Mozziconacci: Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. in BMC cancer 2010 (PubMed)

More Antibodies against ASXL1 Interaction Partners

Mouse (Murine) Additional Sex Combs Like 1 (Drosophila) (ASXL1) interaction partners

  1. implicate Asxl1 in the maintenance of podocyte structure via its association with Wtip (show WTIP Antibodies) and in the regulation of WT1 (show WT1 Antibodies) signaling during early kidney development

  2. ASXL1 truncation mutations confer gain-of-function on the ASXL-BAP1 (show BAP1 Antibodies) complex.

  3. Asxl1-/- fetuses have reduced body weight and display cleft palate, anophthalmia as well as ventricular septal defects and a failure in lung maturation.

  4. Asxl1 functions as a tumor suppressor to maintain hematopoietic cell homeostasis

  5. C-terminal-truncating Asxl1 mutations inhibited myeloid differentiation and induced myelodysplastic syndrome-like disease

  6. Constitutive loss of Asxl1 results in developmental abnormalities, including anophthalmia, microcephaly, cleft palate, and mandibular malformations. Hematopoietic-specific deletion results in cytopenia and dysplasia with increased hematopoietic stem cells

  7. ASXL1 represses, whereas ASXL2 (show ASXL2 Antibodies) increases, the expression of adipogenic genes, most of which are PPARgamma (show PPARG Antibodies) targets

  8. Asxl1 is needed for normal hematopoiesis.

  9. Asxl1and Asxl2 (show ASXL2 Antibodies) are expressed as multiple transcripts, at varying levels, in adult tissues and in embryonic stem cells analyzed by Northern blot, and exhibit similar expression patterns suggesting they may be co-regulated

  10. ASXL1 is a novel coactivator of RAR (show RARA Antibodies) that cooperates with SRC-1 (show NCOA1 Antibodies)

Human Additional Sex Combs Like 1 (Drosophila) (ASXL1) interaction partners

  1. mutations in the SRSF2 (show SRSF2 Antibodies)/ASXL1/RUNX1 (show RUNX1 Antibodies) gene panel identified as significant prognostic markers in systemic mastocytosis

  2. It was found that the absence of mutations in the SRSF2 (show SRSF2 Antibodies), ASXL1, and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

  3. Mutation in ASXL1 gene is associated with chronic myelomonocytic leukemia.

  4. ASXL1 mutation is associated with acute myeloid leukemia (show BCL11A Antibodies).

  5. We examined all ASXL1 truncating variants in the ExAC database and determined most are likely somatic. Failure to consider somatic mosaicism may lead to the inaccurate assumption that conditions like BOS have reduced penetrance, or the misclassification of potentially pathogenic variants.

  6. ASXL1 Circular RNA is Produced by Splicing from its pre-mRNA.

  7. We conclude that ASXL1 is essential for erythroid development and differentiation and that the aberrant differentiation is, at least in part, facilitated via PRC2.

  8. Demonstration of ASXL1 mutation, a putative tumor suppressor gene, represents an important molecular abnormality in CML (show BCR Antibodies). Authors also showed that concomitant detection of BCR-ABL (show ABL1 Antibodies) and JAK2V617F mutations has a relatively high incidence in Iranian patients.

  9. This study showed ASXL1 exon 12 mutations in 16 of 70 (23%) patients with myelofibrosis, with 11 different mutations found in these patients.

  10. Mutations in ASXL1, U2AF1 (show U2AF1 Antibodies), and SF3B1 (show SF3B2 Antibodies) are common in Chinese patients with myelodysplastic syndromes.

ASXL1 Antigen Profile

Antigen Summary

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with ASXL1

  • additional sex combs like 1 (Drosophila) (asxl1) antibody
  • additional sex combs like 1 (LOC100341931) antibody
  • additional sex combs like 1 (asxl1) antibody
  • additional sex combs like 1 (Asxl1) antibody
  • additional sex combs like 1 (Drosophila) (ASXL1) antibody
  • asxl1 antibody
  • BOPS antibody
  • MDS antibody
  • MGC83850 antibody
  • mKIAA0978 antibody

Protein level used designations for ASXL1

additional sex combs like 1 , additional sex combs-like protein 1 , putative Polycomb group protein ASXL1

446414 Xenopus laevis
100341931 Oryctolagus cuniculus
100379981 Xenopus (Silurana) tropicalis
228790 Mus musculus
171023 Homo sapiens
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