ASXL1 Products
(Additional Sex Combs Like 1 (ASXL1))
Categories
This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
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Featured ASXL1 Categories
ASXL1 Antibodies
High quality antibodies with extensive validation data.
ASXL1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ASXL1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (5)
Cat. No.
ABIN949894
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, FACS, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN655084
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IF, IHC (p), EIA
Validations
- (4)
Cat. No.
ABIN950543
Quantity
0.4 mL
Datasheet
Datasheet
Recommended ASXL1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121702
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345902
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3089455
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ASXL1 products
: "Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex." in: Nature communications, Vol. 6, pp. 7307, (2015) (PubMed).: "Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34? progenitor cells." in: British journal of haematology, Vol. 160, Issue 6, pp. 842-50, (2013) (PubMed).
: "A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11." in: Gene, Vol. 306, pp. 115-26, (2003) (PubMed).
Synonyms and alternative names related to ASXL1
additional sex combs like 1, transcriptional regulator L homeolog (asxl1.L), additional sex combs like 1, transcriptional regulator (ASXL1), additional sex combs like 1, transcriptional regulator (asxl1), additional sex combs like 1 (Asxl1), asxl1, BOPS, MDS, MGC83850, mKIAA0978Protein level used designations for ASXL1
- additional sex combs like 1
- additional sex combs-like protein 1
- putative Polycomb group protein ASXL1
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