ASXL1 antibody (C-Term)

Catalog No. ABIN965603

There is 1 publication for this product available. The Rabbit Polyclonal anti-ASXL1 antibody is suitable to detect ASXL1 in samples from Human and Mouse. It has been validated for IHC.

Quick Overview for ASXL1 antibody (C-Term) (ABIN965603)

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASXL1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-ASXL1 Antibody

Binding Specificity: C-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ASXL1(Putative Polycomb group protein ASXL1)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-ASXL1 antibody (ABIN965603)

Fisher, Berger, Randazzo, Brock: "A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11." in: Gene, Vol. 306, pp. 115-26, (2003) (PubMed).

Target Details for ASXL1

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Alternative Name: ASXL1

Background: ASXL1 is the Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. ASXL1 is widely expressed at low level and is highly expressed in testes. ASXL1 contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors.

Pathways: Retinoic Acid Receptor Signaling Pathway