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anti-Human EZH2 Antibodies:
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Human Polyclonal EZH2 Primary Antibody for ChIPSeq, ChIP - ABIN2668958
Knutson, Kawano, Minoshima, Warholic, Huang, Xiao, Kadowaki, Uesugi, Kuznetsov, Kumar, Wigle, Klaus, Allain, Raimondi, Waters, Smith, Porter-Scott, Chesworth, Moyer, Copeland, Richon, Uenaka, Pollock et al.: Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. ... in Molecular cancer therapeutics 2014
Show all 9 Pubmed References
Human Monoclonal EZH2 Primary Antibody for ChIP - ABIN2668955
Bengani, Mendiratta, Maini, Vasanthi, Sultana, Ghasemi, Ahluwalia, Ramachandran, Mishra, Brahmachari: Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome. in PLoS ONE 2013
Show all 8 Pubmed References
Human Polyclonal EZH2 Primary Antibody for WB - ABIN2668957
Izzo, Mercogliano, Venturutti, Tkach, Inurrigarro, Schillaci, Cerchietti, Elizalde, Proietti: Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth. in Breast cancer research : BCR 2015
Show all 7 Pubmed References
Chicken Monoclonal EZH2 Primary Antibody for IF, WB - ABIN968906
Raaphorst, Otte, van Kemenade, Blokzijl, Fieret, Hamer, Satijn, Meijer: Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 2 Pubmed References
Chicken Monoclonal EZH2 Primary Antibody for IF, WB - ABIN968907
van Kemenade, Raaphorst, Blokzijl, Fieret, Hamer, Satijn, Otte, Meijer: Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. in Blood 2001
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Polyclonal EZH2 Primary Antibody for WB - ABIN540724
Hobert, Jallal, Ullrich: Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. in Molecular and cellular biology 1996
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Human Polyclonal EZH2 Primary Antibody for WB - ABIN2668964
Kaneko, Li, Son, Xu, Margueron, Neubert, Reinberg: Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. in Genes & development 2010
Show all 2 Pubmed References
Human Monoclonal EZH2 Primary Antibody for IF, IHC (p) - ABIN659002
Tsai, Manor, Wan, Mosammaparast, Wang, Lan, Shi, Segal, Chang: Long noncoding RNA as modular scaffold of histone modification complexes. in Science (New York, N.Y.) 2010
Show all 6 Pubmed References
Human Polyclonal EZH2 Primary Antibody for ICC, IF - ABIN438771
Hyland, McDade, McCloskey, Dickson, Arthur, McCance, Patel: Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes. in Journal of virology 2011
Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
EZH2-deficient hESCs can initiate differentiation toward developmental lineages; however, they cannot fully differentiate into mature specialized tissues. Thus, EZH2 is required for stable ESC self-renewal, regulation of transcriptional programs, and for late-stage differentiation in this model of early human development.
The finding that EZH2 promotes chemoresistance through SLFN11 silencing suggests that EZH2 inhibition may prevent chemoresistance in patients with SCLC and enhance the efficacy of chemotherapy.
we demonstrate a reduction in myeloma cell proliferation with EZH2 inhibition, which leads to cell cycle arrest followed by apoptosis. This is mediated via upregulation of cyclin-dependent kinase (show CDK1 Antibodies) inhibitors associated with removal of the inhibitory H3K27me3 mark at their gene loci.
Results demonstrate that EZH2 and ALDH1 (show ALDH1A1 Antibodies) proteins are expressed in the stromal component of phyllodes tumors (PTs (show PTS Antibodies)), and that EZH2 is associated with a diagnosis of malignant PT with progression to sarcoma.
Knockdown of EZH2 abolished the function of TUG1 and suppressed cell proliferation while co-transfection of sh-EZH2 and TUG1 expression vector showed that TUG1 promoted cell proliferation inhibited by sh-EZH2.
Low EZH2 or MUS81 (show MUS81 Antibodies) expression levels predict chemoresistance.
High EZH2 expression is associated with colon cancer.
EZH2 expression was significantly associated with markers of poor prognosis such as estrogen receptor (show ESR1 Antibodies) negativity, progesterone receptor (show PGR Antibodies) negativity and high Ki-67 (show MKI67 Antibodies) proliferation index. High EZH2 expression was not correlated with the response to neoadjuvant chemotherapy. Conclusions Our data suggested that EZH2 protein expression may not correlate with the clinical response to neoadjuvant chemotherapy.
Low EZH2 expression is associated with Glioma.
Overexpression of EZH2 was found in 30 patients (76.9%) and was associated with FIGO stage, histological type, and lymph node metastasis (p < 0.05). In conclusion, our data suggest that RIPK4 (show RIPK4 Antibodies)/EZH2 markers might be used as potential predictors of prognosis in cervical cancer.
Gfi1 (show ZNF163 Antibodies) disruption antagonized the tumor-promoting effects of Ezh2 loss; conversely, Gfi1 (show ZNF163 Antibodies) overexpression collaborated with Myc (show MYC Antibodies) to bypass effects of Trp53 (show TP53 Antibodies) inactivation in driving medulloblastoma progression in primary cerebellar neuronal progenitors.
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
High EZH2 expression is associated with Neuroblastoma (show ARHGEF16 Antibodies).
Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement.
These findings indicate that Ezh2 targets are the major targets of the epigenetic switch in MDS (show MECOM Antibodies) with Ezh2 insufficiency.
Insight regarding how androgen-induced extranuclear kinase signaling and intranuclear transcription through Ezh2 modifications may influence the expression pattern of genes, ultimately affecting various downstream physiological processes.
results uncover a crucial role for EZH2 in adaptive lymphocytes to control the developmental timing of effectors of the pre-Ag receptor checkpoints
These findings identify the Ezh2-Hsp90 (show HSP90 Antibodies) interaction as a previously unrecognized mechanism essential for T-cell responses and an effective target for controlling graft-versus-host disease.
Eed (show EED Antibodies) and Ezh2 have distinct roles in urothelial differentiation
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2