EZH2 antibody

Catalog No. ABIN659002

Product Details anti-EZH2 Antibody

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EZH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This EZH2 antibody is generated from mouse immunized with EZH2 recombinant protein.

Clone: 144CT2-1-1-5

Isotype: IgG1, Ig kappa

Application Details

Application Notes: IF: 1:10~50. IF: 1:25. WB: 1:2000. IHC-P: 1:10~50. IHC-P: 1:25. IHC-P: 1:25. IHC: 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-EZH2 antibody (ABIN659002)

Zhang, Ji, Liu, Lei, Li, Ji, Yuan, Jiao: "Ezh2 regulates adult hippocampal neurogenesis and memory." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 15, pp. 5184-99, (2014) (PubMed).

Target Details for EZH2

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Alternative Name: EZH2 (EZH2 Products)

Background: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene.

Molecular Weight: 85363

Gene ID: 2146

NCBI Accession: NP_001190176, NP_001190177, NP_001190178, NP_004447, NP_694543

UniProt: Q15910

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation