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anti-Fruit Fly (Drosophila melanogaster) Antibodies:
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Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors.
Analysis of piRNA clusters in the Drosophila ovary shows that hallmarks of RNA Polymerase II (Pol II) transcription are fundamentally different at uni-strand versus dual-strand clusters. Genome-wide, piRNA production from dual-strand clusters requires the RDC complex consisting of Rhi, Deadlock (Del), and Cuff.
results unveil a link between Cuff activity, heterochromatin assembly and piRNA cluster expression, which is critical for stem-cell and germ-cell development in Drosophila
Involved in the rasiRNA pathway and most likely acts downstream of siRNA biogenesis.