Browse our anti-ALK (ALK) Antibodies

Full name:
anti-Anaplastic Lymphoma Receptor tyrosine Kinase Antibodies (ALK)
On www.antibodies-online.com are 0 Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) Antibodies from different suppliers available. A total of 0 ALK products are currently listed.
Synonyms:
ALK, CD246, NBLST3, Tcrz
list all antibodies Gene Name GeneID UniProt
Anti-Mouse ALK ALK 11682 P97793
Anti-Human ALK ALK 238 Q9UM73
Anti-Rat ALK ALK 266802  

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More Antibodies against ALK Interaction Partners

Mouse (Murine) Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) interaction partners

  1. ALK inhibitor alectinib inhibits tumor growth in a TH-MYCN transgenic neurob (show ARHGEF16 Antibodies)lastoma mouse model.

  2. Alk -/- mice initially consume more ethanol and have increased basal and ethanol-stimulated GABA release in the central nucleus of the amygdala when compared to Alk +/+ mice. After chronic ethanol exposure, Alk +/+ mice escalate their ethanol consumption, whereas Alk -/- mice do not. Basal GABA release in Alk -/- mice is not enhanced by chronic intermittent ethanol-two bottle choice drinking as it is in Alk +/+ mice.

  3. An oral anaplastic lymphoma kinase (ALK) inhibitor.

  4. ALK knock out male mice exhibit hypogonadotropic hypogonadism.

  5. Ethanol activates ALK (and MDK (show MDK Antibodies)) signaling in the brain which regulates behaviors related to alcohol abuse.

  6. Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.

  7. Mutations in the ALK gene is associated with neuroblastoma (show ARHGEF16 Antibodies).

  8. Th-MYCN (show MYCN Antibodies) genetically-engineered murine models of neuroblastoma (show ARHGEF16 Antibodies) using MRI (show C7ORF49 Antibodies), we have identified a marked ALK(F1174L)-driven vascular phenotype.

  9. Reduced ALK1 (show ACVRL1 Antibodies) expression is associated with increased extracellular matrix protein expression, proliferation and migration in fibroblasts.

  10. findings demonstrate a pathogenic role for ALK(F1174L) in neuroblastomas overexpressing MYCN (show MYCN Antibodies) and suggest a strategy for improving targeted therapy for ALK-positive neuroblastoma (show ARHGEF16 Antibodies)

Human Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) interaction partners

  1. Reverse transcription-polymerase chain reaction is a suitable method for detecting ALK translocations using cytology samples from patients with primary lung cancer.

  2. ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma (show ARHGEF16 Antibodies) cells.

  3. We assessed the prevalence of EML4 (show EML4 Antibodies)-ALK rearrangement gene measured by immunohistochemistry in an unselected population-based consecutive cohort of patients with adenocarcinoma of the lung (ACL (show ACLY Antibodies)), and the correlation with smoking history, thyroid transcription factor 1 (TTF1 (show NKX2-1 Antibodies)), gender and age

  4. Nucleophosmin (show NPM1 Antibodies)-anaplastic lymphoma kinase serves as the founding member of the ALK fusion protein family, and its role in malignant cell transformation is by far the best characterized and, thus, is the main focus of this review. [review]

  5. Ventana immunohistochemistry, quantitative real-time reverse transcription-polymerase chain reaction and IHC testing plus fluorescent in situ hybridization confirmation for anaplastic lymphoma kinase testing following crizotinib treatment leaded to the incremental cost-effectiveness ratios

  6. A majority of our ALK positive NSCLC patients were exposed to Crizotinib through the help of various support mechanisms and these patients had similar outcomes to that reported from previously published literature

  7. Mutation in ALK gene is associated with Advanced Lung Adenocarcinoma.

  8. High expression of SLC34A2 (show SLC34A2 Antibodies) was identified in about 2/3 patients and correlated with significantly better patient's overall survival. Epidermal growth factor receptor (show EGFR Antibodies) mutations were detected in about 53% of patients with no statistically significant difference to patient's overall survival. Anaplastic lymphoma kinase rearrangement was found in 8 out of 175 patients, harboring this abnormality leads to shorter overall survi

  9. MYCN (show MYCN Antibodies) overexpression combined with activated anaplastic lymphoma kinase (ALK) is sufficient to induce neuroblastoma (show ARHGEF16 Antibodies) (NB) in mouse sympathoadrenal cells

  10. ALK gene fusion in spitzoid neoplasms results in tumors with a large diameter (>/=9 mm) and wedge-shaped, plexiform dermal architecture of nests of large, spindle-shaped cells .

ALK Antigen Profile

Antigen Summary

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).

Alternative names and synonyms associated with ALK

  • anaplastic lymphoma kinase (Alk) antibody
  • anaplastic lymphoma receptor tyrosine kinase (ALK) antibody
  • ALK tyrosine kinase receptor-like (LOC536642) antibody
  • anaplastic lymphoma receptor tyrosine kinase (Alk) antibody
  • ALK antibody
  • CD246 antibody
  • NBLST3 antibody
  • Tcrz antibody

Protein level used designations for ALK

ALK tyrosine kinase receptor , anaplastic lymphoma kinase (Ki-1) , CD246 antigen , mutant anaplastic lymphoma kinase , anaplastic lymphoma receptor tyrosine kinase , anaplastic lymphoma kinase

GENE ID SPECIES
11682 Mus musculus
421297 Gallus gallus
238 Homo sapiens
483021 Canis lupus familiaris
100518423 Sus scrofa
536642 Bos taurus
266802 Rattus norvegicus
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