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Browse our anti-ALK (ALK) Antibodies

Full name:
anti-Anaplastic Lymphoma Receptor tyrosine Kinase Antibodies (ALK)
On are 0 Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) Antibodies from different suppliers available. A total of 0 ALK products are currently listed.
ALK, CD246, NBLST3, Tcrz
list all antibodies Gene Name GeneID UniProt
Anti-Mouse ALK ALK 11682 P97793
Anti-Human ALK ALK 238 Q9UM73
Anti-Rat ALK ALK 266802  

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More Antibodies against ALK Interaction Partners

Mouse (Murine) Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) interaction partners

  1. Alk -/- mice initially consume more ethanol and have increased basal and ethanol-stimulated GABA release in the central nucleus of the amygdala when compared to Alk +/+ mice. After chronic ethanol exposure, Alk +/+ mice escalate their ethanol consumption, whereas Alk -/- mice do not. Basal GABA release in Alk -/- mice is not enhanced by chronic intermittent ethanol-two bottle choice drinking as it is in Alk +/+ mice.

  2. An oral anaplastic lymphoma kinase (ALK) inhibitor.

  3. ALK knock out male mice exhibit hypogonadotropic hypogonadism.

  4. Ethanol activates ALK (and MDK (show MDK Antibodies)) signaling in the brain which regulates behaviors related to alcohol abuse.

  5. Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.

  6. Mutations in the ALK gene is associated with neuroblastoma (show ARHGEF16 Antibodies).

  7. Th-MYCN (show MYCN Antibodies) genetically-engineered murine models of neuroblastoma (show ARHGEF16 Antibodies) using MRI (show C7ORF49 Antibodies), we have identified a marked ALK(F1174L)-driven vascular phenotype.

  8. Reduced ALK1 (show ACVRL1 Antibodies) expression is associated with increased extracellular matrix protein expression, proliferation and migration in fibroblasts.

  9. findings demonstrate a pathogenic role for ALK(F1174L) in neuroblastomas overexpressing MYCN (show MYCN Antibodies) and suggest a strategy for improving targeted therapy for ALK-positive neuroblastoma (show ARHGEF16 Antibodies)

  10. KLC1 (show KLC1 Antibodies)-ALK is the first novel oncogenic fusion identified using only formalin-fixed paraffin-embedded tissue tissues

Human Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) interaction partners

  1. The primary objective (to determine the maximum tolerated dose) has been reported previously. This updated analysis includes all patients with ALK-rearranged NSCLC given oral ceritinib at the recommended dose of 750 mg/day in the dose-escalation and expansion phases.

  2. ALK was the most commonly mutated gene in this cohort, and we observed a higher frequency of suspected oncogenic ALK mutations in relapsed disease than at diagnosis.

  3. Our findings show that group EML4 (show EML4 Antibodies)-ALK variants 3a/b in non-small cell lung cancer may be a major source of ALK inhibitor resistance in the clinic.

  4. this study shows that anaplastic lymphoma kinase variants might have no correlation with clinical response to crizotinib in non-small-cell lung cancer patients

  5. Data suggest that ALK rearrangement in lung adenocarcinoma is associated with specific and distinct clinical-pathological characters compared to other genotypes.

  6. EMT (show ITK Antibodies) was reversed by miR200c, which suggests that miR200c may serve a role in mediating the sensitivity of NCI2228/CRI cells to crizotinib. The present study may therefore contribute to improving the sensitivity of ALK positive lung cancer cells to crizotinib

  7. the first evidence of an inherited ALK variant in the WNT (show WNT2 Antibodies) type of medulloblastoma

  8. The docking results revealed that ligand interaction with Met 1199 plays a crucial role in binding of inhibitors to ALK

  9. ALK gene copy number gains occurred most due to unspecific polyploidy (whole DNA reduplication) rather than locus specific gene amplification in lung cancer.

  10. These findings suggested that ALK can be considered as a promising target in the targeted therapy in patients with lung ADC (show ADC Antibodies).

ALK Antigen Profile

Antigen Summary

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).

Alternative names and synonyms associated with ALK

  • anaplastic lymphoma kinase (Alk) antibody
  • anaplastic lymphoma receptor tyrosine kinase (ALK) antibody
  • ALK tyrosine kinase receptor-like (LOC536642) antibody
  • anaplastic lymphoma receptor tyrosine kinase (Alk) antibody
  • ALK antibody
  • CD246 antibody
  • NBLST3 antibody
  • Tcrz antibody

Protein level used designations for ALK

ALK tyrosine kinase receptor , anaplastic lymphoma kinase (Ki-1) , CD246 antigen , mutant anaplastic lymphoma kinase , anaplastic lymphoma receptor tyrosine kinase , anaplastic lymphoma kinase

11682 Mus musculus
421297 Gallus gallus
238 Homo sapiens
483021 Canis lupus familiaris
100518423 Sus scrofa
536642 Bos taurus
266802 Rattus norvegicus
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