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Browse our anti-ALK (ALK) Antibodies

Full name:
anti-Anaplastic Lymphoma Receptor tyrosine Kinase Antibodies (ALK)
On www.antibodies-online.com are 1 Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) Antibodies from 1 different suppliers available. A total of 1 ALK products are currently listed.
Synonyms:
ALK, CD246, NBLST3, Tcrz
list all antibodies Gene Name GeneID UniProt
ALK 11682 P97793
ALK 238 Q9UM73
ALK 266802  

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Most Popular Reactivities for anti-ALK (ALK) Antibodies

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anti-Mouse (Murine) ALK Antibodies:

anti-Human ALK Antibodies:

anti-Rat (Rattus) ALK Antibodies:

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More Antibodies against ALK Interaction Partners

Mouse (Murine) Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) interaction partners

  1. An oral anaplastic lymphoma kinase (ALK) inhibitor.

  2. ALK knock out male mice exhibit hypogonadotropic hypogonadism.

  3. Ethanol activates ALK (and MDK (show MDK Antibodies)) signaling in the brain which regulates behaviors related to alcohol abuse.

  4. Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.

  5. Mutations in the ALK gene is associated with neuroblastoma (show ARHGEF16 Antibodies).

  6. Th-MYCN (show MYCN Antibodies) genetically-engineered murine models of neuroblastoma (show ARHGEF16 Antibodies) using MRI (show C7ORF49 Antibodies), we have identified a marked ALK(F1174L)-driven vascular phenotype.

  7. Reduced ALK1 (show ACVRL1 Antibodies) expression is associated with increased extracellular matrix protein expression, proliferation and migration in fibroblasts.

  8. findings demonstrate a pathogenic role for ALK(F1174L) in neuroblastomas overexpressing MYCN (show MYCN Antibodies) and suggest a strategy for improving targeted therapy for ALK-positive neuroblastoma (show ARHGEF16 Antibodies)

  9. KLC1 (show KLC1 Antibodies)-ALK is the first novel oncogenic fusion identified using only formalin-fixed paraffin-embedded tissue tissues

  10. In hippocampus, Alk and Ltk (leukocyte tyrosine kinase (show LTK Antibodies)) are expressed throughout dentate gyrus, CA1 (show CA1 Antibodies), and CA3 (show CA3 Antibodies). Data suggest enhanced performance in spatial memory and reduced neurogenesis in Alk mutant/knockout mice.

Human Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) interaction partners

  1. While FISH techniques have been implemented to characterize this translocation for some time, the implementation of this testing is hampered by its broad use of resources. Immunohistochemical techniques to identify and screen for EML4 (show EML4 Antibodies)-ALK translocations may play an important role in the near future. This consensus paper offers recommendations of the sequence and quality of the respective test approaches which are validate

  2. ALK gene rearrangement is associated with pulmonary adenocarcinoma.

  3. ALK fusions occur in approximately 5% of lung adenocarcinoma and typically occur in a mutually exclusive manner to EGFR (show EGFR Antibodies) mutations.

  4. or patients with non-small cell lung cancer with a EGFR (show EGFR Antibodies) mutation and an anaplastic lymphoma kinase mutation(ALK) with brain metastases, several agents have shown intracranial activity. Lapatinib has been tested for patients with brain metastases from breast cancer harboring a HER2 (show ERBB2 Antibodies) mutation. molecular targeted therapies have shown efficacy in BRAF (show BRAF Antibodies)-positive melanoma brain metastasis

  5. Given that the ALK immunohistochemical staining pattern is associated with the ALK fusion partner, the present results suggest that the prognosis for ALK positive large B-cell lymphoma differs depending on the ALK fusion partner.

  6. ALK rearrangements are associated with non-small-cell lung cancer.

  7. overexpression of phospho-ALK and alternative receptor tyrosine kinases such as phospho-EGFR (show EGFR Antibodies), phospho-HER3 (show ERBB3 Antibodies), and phospho-IGFR-1R was observed in both resistant cell lines. Additionally, NRG1 (show NRG1 Antibodies), a ligand for HER3 (show ERBB3 Antibodies), is upregulated and responsible for resistance by activating the EGFR (show EGFR Antibodies) family pathways through the NRG1 (show NRG1 Antibodies)-HER3 (show ERBB3 Antibodies)-EGFR (show EGFR Antibodies) axis.

  8. case report in which the EML4 (show EML4 Antibodies)-ALK fusion gene was identified as a second primary lung cancer after surgically resecting EGFR (show EGFR Antibodies) mutation-positive adenocarcinoma

  9. 79 (69%) were negative for echinoderm microtubule-associated protein like 4 (EML4 (show EML4 Antibodies))-ALK translocation, nine (8%) were positive and 27 (23%) were unevaluable.

  10. our study suggested that the prevalence of ALK, ROS1 (show ROS1 Antibodies) and RET (show RET Antibodies) fusions is very rare in lung squamous cell carcinoma patients.

ALK Antigen Profile

Antigen Summary

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).

Alternative names and synonyms associated with ALK

  • anaplastic lymphoma kinase (Alk) antibody
  • anaplastic lymphoma receptor tyrosine kinase (ALK) antibody
  • ALK tyrosine kinase receptor-like (LOC536642) antibody
  • anaplastic lymphoma receptor tyrosine kinase (Alk) antibody
  • ALK antibody
  • CD246 antibody
  • NBLST3 antibody
  • Tcrz antibody

Protein level used designations for ALK

ALK tyrosine kinase receptor , anaplastic lymphoma kinase (Ki-1) , CD246 antigen , mutant anaplastic lymphoma kinase , anaplastic lymphoma receptor tyrosine kinase , anaplastic lymphoma kinase

GENE ID SPECIES
11682 Mus musculus
421297 Gallus gallus
238 Homo sapiens
483021 Canis lupus familiaris
100518423 Sus scrofa
536642 Bos taurus
266802 Rattus norvegicus
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