Browse our anti-ALK (ALK) Antibodies

Full name:
anti-Anaplastic Lymphoma Receptor tyrosine Kinase Antibodies (ALK)
On www.antibodies-online.com are 0 Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) Antibodies from different suppliers available. A total of 0 ALK products are currently listed.
Synonyms:
ALK, CD246, NBLST3, Tcrz
list all antibodies Gene Name GeneID UniProt
Anti-Mouse ALK ALK 11682 P97793
Anti-Human ALK ALK 238 Q9UM73
Anti-Rat ALK ALK 266802  

Show all synonyms

More Antibodies against ALK Interaction Partners

Mouse (Murine) Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) interaction partners

  1. ALKR1275Q cooperated with MYCN (show MYCN Antibodies) in the development of aggressive NB, possibly by downregulating the expression of ECM (show MMRN1 Antibodies)/BM-associated genes and by conferring malignant potentials to MYCN (show MYCN Antibodies)-expressing cells.

  2. ALK inhibitor alectinib inhibits tumor growth in a TH-MYCN transgenic neurob (show ARHGEF16 Antibodies)lastoma mouse model.

  3. Alk -/- mice initially consume more ethanol and have increased basal and ethanol-stimulated GABA release in the central nucleus of the amygdala when compared to Alk +/+ mice. After chronic ethanol exposure, Alk +/+ mice escalate their ethanol consumption, whereas Alk -/- mice do not. Basal GABA release in Alk -/- mice is not enhanced by chronic intermittent ethanol-two bottle choice drinking as it is in Alk +/+ mice.

  4. An oral anaplastic lymphoma kinase (ALK) inhibitor.

  5. ALK knock out male mice exhibit hypogonadotropic hypogonadism.

  6. Ethanol activates ALK (and MDK (show MDK Antibodies)) signaling in the brain which regulates behaviors related to alcohol abuse.

  7. Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.

  8. Mutations in the ALK gene is associated with neuroblastoma (show ARHGEF16 Antibodies).

  9. Th-MYCN (show MYCN Antibodies) genetically-engineered murine models of neuroblastoma (show ARHGEF16 Antibodies) using MRI (show C7ORF49 Antibodies), we have identified a marked ALK(F1174L)-driven vascular phenotype.

  10. Reduced ALK1 (show ACVRL1 Antibodies) expression is associated with increased extracellular matrix protein expression, proliferation and migration in fibroblasts.

Human Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) interaction partners

  1. Our results suggest that the dynamic change in the numbers of circulating tumor cells (CTC) with ALK-CNG (show CNGA1 Antibodies) may be a predictive biomarker for crizotinib efficacy in ALK-rearranged non-small cell lung cancer (NSCLC)patients. Serial molecular analysis of CTC shows promise for real-time patient monitoring and clinical outcome prediction in this population.

  2. Studies indicate that aberrant AXL receptor tyrosine kinase (AXL (show AXL Antibodies)) signaling and development of an epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) phenotype underlie resistance of anaplastic lymphoma kinase (ALK F1174L)-driven neuroblastoma (show ARHGEF16 Antibodies) (NB) cells to TAE684 and its derivatives.

  3. Knockdown of SMYD2 (show SMYD2 Antibodies) as well as treatment with a SMYD2 (show SMYD2 Antibodies) inhibitor in two NSCLC cell lines with an EML4 (show EML4 Antibodies)-ALK gene significantly attenuated the phosphorylation levels of the EML4 (show EML4 Antibodies)-ALK protein.

  4. Data indicate that NPM (show NPM1 Antibodies)-ALK was distributed in equal amounts between the cytoplasm and the nucleus.

  5. The EML4 (show EML4 Antibodies)-ALK-mediated upregulation of HIF1alpha (show HIF1A Antibodies), HK2 (show HK2 Antibodies) and glycolytic metabolism was also highly active in vivo as demonstrated by fluorodeoxyglucose-positron emission tomography imaging of xenografts grown from EML4 (show EML4 Antibodies)-ALK-positive NSCLC cells.

  6. Results indicate that ALK expression, at both the RNA and the protein levels, is strongly associated with the WNT (show WNT2 Antibodies)-activated type of tumors and therefore may serve as a useful marker for the detection of this type of medulloblastoma. Importantly, ALK protein expression alone is also an indicator of good prognosis for medulloblastoma patients.

  7. Reverse transcription-polymerase chain reaction is a suitable method for detecting ALK translocations using cytology samples from patients with primary lung cancer.

  8. ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma (show ARHGEF16 Antibodies) cells.

  9. We assessed the prevalence of EML4 (show EML4 Antibodies)-ALK rearrangement gene measured by immunohistochemistry in an unselected population-based consecutive cohort of patients with adenocarcinoma of the lung (ACL (show ACLY Antibodies)), and the correlation with smoking history, thyroid transcription factor 1 (TTF1 (show NKX2-1 Antibodies)), gender and age

  10. Nucleophosmin (show NPM1 Antibodies)-anaplastic lymphoma kinase serves as the founding member of the ALK fusion protein family, and its role in malignant cell transformation is by far the best characterized and, thus, is the main focus of this review. [review]

ALK Antigen Profile

Antigen Summary

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).

Alternative names and synonyms associated with ALK

  • anaplastic lymphoma kinase (Alk) antibody
  • anaplastic lymphoma receptor tyrosine kinase (ALK) antibody
  • ALK tyrosine kinase receptor-like (LOC536642) antibody
  • anaplastic lymphoma receptor tyrosine kinase (Alk) antibody
  • ALK antibody
  • CD246 antibody
  • NBLST3 antibody
  • Tcrz antibody

Protein level used designations for ALK

ALK tyrosine kinase receptor , anaplastic lymphoma kinase (Ki-1) , CD246 antigen , mutant anaplastic lymphoma kinase , anaplastic lymphoma receptor tyrosine kinase , anaplastic lymphoma kinase

GENE ID SPECIES
11682 Mus musculus
421297 Gallus gallus
238 Homo sapiens
483021 Canis lupus familiaris
100518423 Sus scrofa
536642 Bos taurus
266802 Rattus norvegicus
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