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ALK Products

(Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

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This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).[provided by RefSeq, Jan 2011].

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Featured ALK Categories

ALK Antibodies

High quality antibodies with extensive validation data.

Recommended ALK Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (3)
Cat. No. ABIN3029939
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7339896
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (2)
Cat. No. ABIN7368872
Quantity 50 μg
Datasheet Datasheet

Recommended ALK Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7272289
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7282100
Quantity 200 μg
Datasheet Datasheet

Latest Publications for our ALK products

Jain, Jangra, Malik, Arulselvi, Madan, Mathur, Sharma: "Anaplastic lymphoma kinase immunohistochemistry in lung adenocarcinomas: Evaluation of performance of standard manual method using D5F3 antibody." in: Indian journal of cancer, Vol. 54, Issue 1, pp. 209-213, (2018) (PubMed).

Du, Gao, Zhao, Li, Xue, Wang: "Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma." in: Oncology letters, Vol. 15, Issue 6, pp. 9317-9326, (2018) (PubMed).

Gao, Li, Jiang, Zhan, Yan, Zhang, Huang: "Worse disease-free, tumor-specific, and overall survival in surgically-resected lung adenocarcinoma patients with ALK rearrangement." in: Oncotarget, Vol. 8, Issue 49, pp. 86066-86081, (2017) (PubMed).

Liu, Mathialagan, Lappin, Fortner, Somps, Seitis, Johnson, Hu, Matsumoto: "Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 116-25, (2016) (PubMed).

Gruber, Kohlhäufl, Friedel, Ott, Kalla: "A novel, highly sensitive ALK antibody 1A4 facilitates effective screening for ALK rearrangements in lung adenocarcinomas by standard immunohistochemistry." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 10, Issue 4, pp. 713-6, (2015) (PubMed).

Collin, Charles, Barker, Khosa, Samnakay: "Inflammatory myofibroblastic tumour of the bladder in children: A review." in: Journal of pediatric urology, (2015) (PubMed).

Wang, He, Yang, Wang, Xiao: "Extraordinary response to crizotinib in a woman with squamous cell lung cancer after two courses of failed chemotherapy." in: BMC pulmonary medicine, Vol. 14, pp. 83, (2014) (PubMed).

Florio, Cesaro, Montano, Izzo, Miles, Costanzo: "Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms." in: Human molecular genetics, Vol. 19, Issue 18, pp. 3544-56, (2010) (PubMed).

Pulford, Lamant, Morris, Butler, Wood, Stroud, Delsol, Mason: "Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1." in: Blood, Vol. 89, Issue 4, pp. 1394-404, (1997) (PubMed).

Synonyms and alternative names related to ALK

anaplastic lymphoma kinase (Alk), anaplastic lymphoma receptor tyrosine kinase (ALK), ALK receptor tyrosine kinase (ALK), ALK receptor tyrosine kinase (Alk), ALK, CD246, NBLST3, Tcrz

Protein level used designations for ALK

  • ALK tyrosine kinase receptor
  • anaplastic lymphoma kinase (Ki-1)
  • CD246 antigen
  • mutant anaplastic lymphoma kinase
  • anaplastic lymphoma receptor tyrosine kinase
  • anaplastic lymphoma kinase
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