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Human Angiopoietin 2 Protein expressed in CHO Cells - ABIN2666460
Fiedler, Scharpfenecker, Koidl, Hegen, Grunow, Schmidt, Kriz, Thurston, Augustin: The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. in Blood 2004
Show all 6 references for ABIN2666460
Mouse (Murine) Angiopoietin 2 Protein expressed in Human Cells - ABIN2007632
Maisonpierre, Suri, Jones, Bartunkova, Wiegand, Radziejewski, Compton, McClain, Aldrich, Papadopoulos, Daly, Davis, Sato, Yancopoulos: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. in Science (New York, N.Y.) 1997
Show all 6 references for ABIN2007632
Human Angiopoietin 2 Protein expressed in Human Cells - ABIN2003235
Schliemann, Bieker, Thoennissen, Gerss, Liersch, Kessler, Büchner, Berdel, Mesters: Circulating angiopoietin-2 is a strong prognostic factor in acute myeloid leukemia. in Leukemia 2007
Show all 6 references for ABIN2003235
Human Angiopoietin 2 Protein expressed in Human - ABIN1344329
Kim, Shin, Kim, Choi, Byun, Jeon, Suh, Kim: Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells. in Cardiovascular research 2006
Shear stress activated Ang-2 via canonical Wnt signaling in vascular endothelial cells, and Wnt-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
NDPKB is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 and Ang2.
Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 (show IL18 Proteins) expression
ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development
This study identifies angiopoietin-2 as a link between kidney fibrosis and arterial stiffness.
vitamin D-VDR (show CYP27B1 Proteins) signaling prevents lung injury by blocking the Ang-2-Tie-2 (show TEK Proteins)-MLC kinase cascade and the renin (show REN Proteins)-angiotensin system.
Angiopoietin-2 was expressed on lymphatic vessels and macrophages in inflamed cornea. While corneal LG response was abolished in Ang-2 knockout mice.
The Ang-1 (show ANGPT1 Proteins), Ang-2, Tie-2 (show TEK Proteins) system takes part in the pathologic processes in the brains that suffered acute carbon monoxide poisoning by participating in neovascularization.
We conclude that aging shifts the balance of the Ang1/Ang2 network favouring a quiescent state. Activation of endothelial cells in aging might be necessary to enhance wound healing capacities.
Ang2/Ang1 (show ANGPT1 Proteins) ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target.
Results demonstrate that Ang-2 expression significantly correlated with poor prognosis for patients with non-small cell lung cancer. [meta-analysis]
Our results show that miR (show MLXIP Proteins)-181a is down-regulated in glioblastoma multiforme (GBM) patients. The three target genes, ANGPT2, ARHGAP18 (show ARHGAP18 Proteins) and LAMC1 (show LAMC1 Proteins), are negatively correlated with the expression of miR (show MLXIP Proteins)-181a. Moreover, high expression of ANGPT2 or LAMC1 (show LAMC1 Proteins) together with large size of GBM is correlated with a shorter median overall survival
These results suggested that IL-35 restrains rheumatoid arthritis angiogenesis and inflammation by downregulating basal and VEGF (show VEGFA Proteins)-induced Ang2 secretion as well as disrupting Ang2/Tie2 (show TEK Proteins) signal transduction.
High Ang 1 expression in hilar cholangiocarcinoma and infiltration of TIE2-expressing monocytes (TEMs) defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Low Ang 2 levels tended to inversely correlate with TEMs invasion.
This study identified Ang-2 as an endothelial cell-derived regulator of BBB permeability.
Serum Ang-2 may be a relevant predictor of Acute Pancreatitis severity, in particular of the development of AP-renal syndrome.
the homeostasis of vascular endothelial function by Ang-1 (show ANGPT1 Proteins) and Ang-2 is disrupted in macrophage activation syndrome (MAS (show MAS1 Proteins)); the Ang-2/1 ratio was significantly elevated in the active phase of s-JIA; serum Ang-1 (show ANGPT1 Proteins) levels were significantly decreased in MAS (show MAS1 Proteins), whereas the serum Ang-2 levels and the Ang-2/1 ratio were significantly elevated in MAS (show MAS1 Proteins)
Data show that angiopoietin-2 (Ang-2) and bacterial endotoxins (LPS (show IRF6 Proteins)) follow opposite kinetics in serum in acute pyelonephritis.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, Angiopoietin-2B (Ang-2B)