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Human Angiopoietin 2 Protein expressed in CHO Cells - ABIN2666460
Fiedler, Scharpfenecker, Koidl, Hegen, Grunow, Schmidt, Kriz, Thurston, Augustin: The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. in Blood 2004
Show all 6 references for ABIN2666460
Mouse (Murine) Angiopoietin 2 Protein expressed in Human Cells - ABIN2007632
Maisonpierre, Suri, Jones, Bartunkova, Wiegand, Radziejewski, Compton, McClain, Aldrich, Papadopoulos, Daly, Davis, Sato, Yancopoulos: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. in Science (New York, N.Y.) 1997
Show all 6 references for ABIN2007632
Human Angiopoietin 2 Protein expressed in Human Cells - ABIN2003237
Schliemann, Bieker, Thoennissen, Gerss, Liersch, Kessler, Büchner, Berdel, Mesters: Circulating angiopoietin-2 is a strong prognostic factor in acute myeloid leukemia. in Leukemia 2007
Show all 6 references for ABIN2003237
Human Angiopoietin 2 Protein expressed in Human - ABIN1344329
Kim, Shin, Kim, Choi, Byun, Jeon, Suh, Kim: Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells. in Cardiovascular research 2006
Shear stress activated Ang-2 via canonical Wnt signaling in vascular endothelial cells, and Wnt-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.
NDPKB is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 and Ang2.
Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 (show IL18 Proteins) expression
ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development
This study identifies angiopoietin-2 as a link between kidney fibrosis and arterial stiffness.
vitamin D-VDR (show CYP27B1 Proteins) signaling prevents lung injury by blocking the Ang-2-Tie-2 (show TEK Proteins)-MLC kinase cascade and the renin (show REN Proteins)-angiotensin system.
Angiopoietin-2 was expressed on lymphatic vessels and macrophages in inflamed cornea. While corneal LG response was abolished in Ang-2 knockout mice.
This study reveals ANGPT2 as a new susceptibility gene for nAMD and PCV, and it may affect disease susceptibility in association with CFH (show CFH Proteins).
We could therefore conclude that angiogenesis is an important event in the development of common skin warts, and the upregulation of both Ang1 (show ANGPT1 Proteins) and -2 and their binding receptor Tie2 (show TEK Proteins) may play a role in the angiogenesis associated with the development of these lesions.
Data suggest that the associations among angiopoietin-2, sFlt-1, coagulation abnormalities and severe course of acute pancreatitis (AP) might be mediated by other bioactive compounds.
there was no immunohistochemical evidence for apoptosis or autophagy. Quantitative staining showed similar expression levels of the angiogenesis regulators VEGF-A (show VEGFA Proteins), VEGF-receptor 2 and Angpt1 (show ANGPT1 Proteins) (p = 0.11), but Angpt2 was significantly lower in CKD children (p = 0.01).
Ang-1 (show ANGPT1 Proteins) and -2 levels and the Ang-2/Ang-1 (show ANGPT1 Proteins) ratio may be promising indicators of disease activity in hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli.
An imbalance in ANGPT-2, combined with related factors such as VEGF (show VEGFA Proteins), beta-catenin (show CTNNB1 Proteins), and MMP-2 (show MMP2 Proteins), may partially explain the structural derangements of the arterial wall in patients with chronic obstructive pulmonary disease.
We conclude that aging shifts the balance of the Ang1/Ang2 network favouring a quiescent state. Activation of endothelial cells in aging might be necessary to enhance wound healing capacities.
Ang2/Ang1 (show ANGPT1 Proteins) ratio might constitute a useful tool for monitoring the progression of chronic liver disease towards cirrhosis and play an important role as therapeutic target.
Results demonstrate that Ang-2 expression significantly correlated with poor prognosis for patients with non-small cell lung cancer. [meta-analysis]
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, Angiopoietin-2B (Ang-2B)