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kinase AXL drives the mesenchymal gene signature and motility of ovarian tumor cells.
The AXL inhibitor R428 attenuated RTK and ERK (show EPHB2 Proteins) activation and reduced cell motility in Mes (show ME1 Proteins) cells in culture and reduced tumor growth
These results highlight the dual role of Axl during Zika virus infection of glial cells: promoting viral entry and modulating innate immune responses.
The expression of AXL was positively associated with GAS6 expression (P < 0.001), and tumor differentiation (P = 0.014) in advanced NSCLC with metastases. AXL expression displayed no association with gender, age, smoking history, pathology, T stage, N stage, CEA, and LDH.
Data indicate a role for AXL receptor tyrosine kinase (AXL) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR (show EGFR Proteins)) and suggest that AXL-mediated SRC (show SRC Proteins) family kinases (SFKs) and neuregulin-1 (NRG1 (show NRG1 Proteins)) expression promote this process.
Combination of high serum levels of soluble AXL and BNP had greater predictive value for heart failure than BNP alone.
These results demonstrate that Gas6 (show GAS6 Proteins)/Axl axis confers aggressiveness in breast cancer.
a lower stability and greater dynamic nature of the Axl kinase domain
Silencing AXL or the inhibition of AXL kinase activity significantly inhibits tumor cell migration and invasion in colorectal cancer.
we identify PROS1 (show PROS1 Proteins) as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL expression
These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.
GAS6 (show GAS6 Proteins)-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 (show NLRP3 Proteins) inflammasome activation.
Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.
reciprocal activation of Axl and Mer (show ERH Proteins) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
Axl, Mertk (show MERTK Proteins) and Tyro3 (show TYRO3 Proteins) receptors are not required for Zika virus entry and infection.
Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.
Matrix metalloproteases ADAM10 (show ADAM10 Proteins) and TACE (ADAM17 (show ADAM17 Proteins)) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.
Gas6 (show GAS6 Proteins)/Axl and Akt (show AKT1 Proteins)/FoxO1a (show FOXO1 Proteins) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
activation of receptor tyrosine kinase (show RET Proteins) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog