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Human AXL Protein expressed in HEK-293 Cells - ABIN2180607
Varnum, Young, Elliott, Garcia, Bartley, Fridell, Hunt, Trail, Clogston, Toso: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. in Nature 1995
Show all 4 references for ABIN2180607
Mouse (Murine) AXL Protein expressed in Human Cells - ABIN2007365
Nagata, Ohashi, Nakano, Arita, Zong, Hanafusa, Mizuno: Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. in The Journal of biological chemistry 1997
Show all 3 references for ABIN2007365
Human AXL Protein expressed in Human Cells - ABIN2002499
Braunger, Schleithoff, Schulz, Kessler, Lammers, Ullrich, Bartram, Janssen: Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. in Oncogene 1997
Show all 3 references for ABIN2002499
suggest that targeting receptor tyrosine kinase (show RET Proteins) AXL (RTK-AXL) with BMS-777607 could represent a regimen for the treatment of primary and recurrent glioblastoma multiforme (GBM).
AXL is frequently expressed in high-grade serous ovarian cancers and its expression is significantly associated to tumors displaying poor prognosis.
Data suggest that AXL receptor tyrosine kinase (Axl) may facilitate tumour progression by promoting nasopharyngeal carcinoma (NPC (show NPC1 Proteins)) cell migration and invasion.
High expression of Axl correlated with Upper Tract Urothelial Carcinoma.
Vimentin (show VIM Proteins) and Axl mRNA and protein were expressed in a subset of human TNBC tumors.
Incubation with sunitinib of renal cell carcinoma (show MOK Proteins) cells causes significant upregulation of multiple phosphopeptides including Axl.
Identified an Axl-associated signature of 62 genes able to portray the high-grade ovarian cancer patients with the shortest overall survival.
AXL may have a role in proliferation, migration and survival in colorectal cancer cells
High HIF-1alpha expression is significantly associated with Axl and VEGF expression, and with markers of poor prognosis in this series of breast cancer.
Negative feedback regulation of AXL by miR (show MLXIP Proteins)-34a modulates apoptosis in lung cancer cells by activating the transcription factor ELK1 (show ELK1 Proteins) via the JNK (show MAPK8 Proteins) signaling pathway.
Gas6 (show GAS6 Proteins)/Axl and Akt (show AKT1 Proteins)/FoxO1a (show FOXO1 Proteins) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
results establish TAM (show CCNA1 Proteins) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease
These results suggest that TAM (show CCNA1 Proteins) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Gas6 (show GAS6 Proteins)-induced Axl signaling is a critical driver of pancreatic cancer progression.
The results indicate that Axl and Mer (show ERH Proteins) receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.
Vascular depletion of Axl reduced vein graft stiffness. Axl expression determined the STAT1 (show STAT1 Proteins)-SOCS1 (show SOCS1 Proteins) balance in vein graft intima and progression of the remodeling.
Gas6 (show GAS6 Proteins)/Axl signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Proteins)/FoxO (show FOXO3 Proteins) signaling pathway.
Low MITF (show MITF Proteins)/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
nuclear receptor agonists increase MerTK (show MERTK Proteins) and Axl expression on plaque-associated immune cells, consequently licensing their phagocytic activity and promoting plaque clearance.
activation of receptor tyrosine kinase (show RET Proteins) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog