Browse our AXL Proteins (AXL)

Full name:
AXL Receptor tyrosine Kinase Proteins (AXL)
On are 20 AXL Receptor tyrosine Kinase (AXL) Proteins from 10 different suppliers available. Additionally we are shipping AXL Antibodies (295) and AXL Kits (30) and many more products for this protein. A total of 362 AXL products are currently listed.
AI323647, Ark, JTK11, Tyro7, Ufo
list all proteins Gene Name GeneID UniProt
AXL 558 P30530
AXL 26362 Q00993
AXL 308444  

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AXL Proteins (AXL) by Origin

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Top referenced AXL Proteins

  1. Human AXL Protein expressed in HEK-293 Cells - ABIN2180607 : Varnum, Young, Elliott, Garcia, Bartley, Fridell, Hunt, Trail, Clogston, Toso: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. in Nature 1995 (PubMed)
    Show all 4 references for 2180607

  2. Mouse (Murine) AXL Protein expressed in Human Cells - ABIN2007365 : Nagata, Ohashi, Nakano, Arita, Zong, Hanafusa, Mizuno: Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. in The Journal of biological chemistry 1997 (PubMed)
    Show all 3 references for 2007365

  3. Human AXL Protein expressed in Human Cells - ABIN2002499 : Braunger, Schleithoff, Schulz, Kessler, Lammers, Ullrich, Bartram, Janssen: Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. in Oncogene 1997 (PubMed)
    Show all 3 references for 2002499

More Proteins for AXL Interaction Partners

Human AXL Receptor tyrosine Kinase (AXL) interaction partners

  1. Silencing AXL or the inhibition of AXL kinase activity significantly inhibits tumor cell migration and invasion in colorectal cancer.

  2. we identify PROS1 (show PROS1 Proteins) as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL expression

  3. Studies indicate that aberrant AXL receptor tyrosine kinase (AXL) signaling and development of an epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) phenotype underlie resistance of anaplastic lymphoma kinase (ALK F1174L)-driven neuroblastoma (show ARHGEF16 Proteins) (NB) cells to TAE684 and its derivatives.

  4. Studied axl kinase as a negative regulator of an alveolar epithelial cell phenotype; results found that inhibition of Axl kinase could form epithelial adhesion structure and augment surfactant protein production via the MET of human lung multi-potent cells.

  5. AXL is efficiently and sequentially cleaved by alpha- and gamma-secretases in various types of cancer cell lines. The AXL intracellular domain cleavage product translocates into the nucleus via a nuclear localization sequence that harbored a basic HRRKK motif.

  6. a relationship between AXL and the cellular response to DNA damage whereby abrogation of AXL signaling leads to accumulation of the DNA-damage markers gammaH2AX (show H2AFX Proteins), 53BP1 (show TP53BP1 Proteins), and RAD51 (show RAD51 Proteins).

  7. Small molecule and antibody inhibitors of AXL and MER (show MERTK Proteins) have recently been described, and some of these have already entered clinical trials. The optimal design of treatment strategies to maximize the clinical benefit of these AXL and MER (show MERTK Proteins) targeting agents are discussed in relation to the different cancer types and the types of resistance encountered.

  8. our results demonstrate that AR can promote melanoma metastasis via altering the miRNA-539-3p/USP13 (show USP13 Proteins)/MITF (show MITF Proteins)/AXL signal and targeting this newly identified signal with AR degradation enhancer ASC (show PYCARD Proteins)-J9 may help us to better suppress the melanoma metastasis.

  9. AXL can be an effective therapeutic target in combination with targeted therapy such as PARP inhibitors in several different malignancies.

  10. AXL/TAZ (show TAZ Proteins)/YAP (show YAP1 Proteins) expression is associated with poor prognosis in male breast cancer patients.

Mouse (Murine) AXL Receptor tyrosine Kinase (AXL) interaction partners

  1. Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.

  2. reciprocal activation of Axl and Mer (show ERH Proteins) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.

  3. Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.

  4. Axl, Mertk (show MERTK Proteins) and Tyro3 (show TYRO3 Proteins) receptors are not required for Zika virus entry and infection.

  5. Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.

  6. Matrix metalloproteases ADAM10 (show ADAM10 Proteins) and TACE (ADAM17 (show ADAM17 Proteins)) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.

  7. Gas6 (show GAS6 Proteins)/Axl and Akt (show AKT1 Proteins)/FoxO1a (show FOXO1 Proteins) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.

  8. Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.

  9. results establish TAM (show CCNA1 Proteins) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease

  10. These results suggest that TAM (show CCNA1 Proteins) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.

Cow (Bovine) AXL Receptor tyrosine Kinase (AXL) interaction partners

  1. activation of receptor tyrosine kinase (show RET Proteins) Axl inhibits the osteogenic differentiation of vascular pericytes.

AXL Protein Profile

Protein Summary

The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with AXL

  • AXL receptor tyrosine kinase (AXL)
  • AXL receptor tyrosine kinase (Axl)
  • Axl receptor tyrosine kinase (Axl)
  • AI323647 protein
  • Ark protein
  • JTK11 protein
  • Tyro7 protein
  • Ufo protein

Protein level used designations for AXL

AXL oncogene , AXL transforming sequence/gene , tyrosine-protein kinase receptor UFO , adhesion-related kinase , ufo oncogene homolog

100064907 Equus caballus
558 Homo sapiens
26362 Mus musculus
308444 Rattus norvegicus
484490 Canis lupus familiaris
100144875 Sus scrofa
516598 Bos taurus
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