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Browse our MERTK Proteins (MERTK)

Full name:
C-Mer Proto-Oncogene Tyrosine Kinase Proteins (MERTK)
On are 23 C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) Proteins from 9 different suppliers available. Additionally we are shipping MERTK Antibodies (177) and MERTK Kits (21) and many more products for this protein. A total of 237 MERTK products are currently listed.
C-EYK, c-mer, DKFZp469D2215, Eyk, Mer, MERTK, nmf12, Nyk, rdy, RP38, si:ch1073-268l12.2
list all proteins Gene Name GeneID UniProt
MERTK 10461 Q12866
MERTK 17289 Q60805
MERTK 65037 P57097

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MERTK Proteins (MERTK) by Origin

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Top referenced MERTK Proteins

  1. Human MERTK Protein expressed in Baculovirus infected Insect Cells - ABIN3216422 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)
    Show all 3 references for ABIN3216422

  2. Human MERTK Protein expressed in Baculovirus infected Insect Cells - ABIN2002536 : Gal, Li, Thompson, Weir, Orth, Jacobson, Apfelstedt-Sylla, Vollrath: Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. in Nature genetics 2000 (PubMed)
    Show all 3 references for ABIN2002536

  3. Mouse (Murine) MERTK Protein expressed in Baculovirus infected Insect Cells - ABIN2007918 : Oppermann, Gnad, Olsen, Hornberger, Greff, Kéri, Mann, Daub: Large-scale proteomics analysis of the human kinome. in Molecular & cellular proteomics : MCP 2009 (PubMed)
    Show all 3 references for ABIN2007918

More Proteins for MERTK Interaction Partners

Human C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) interaction partners

  1. The rs4374383 AA genotype, associated with lower intrahepatic expression of MERTK, is protective against F2-F4 fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).

  2. We report a novel missense mutation (c.3G>A, p.0?) in the MERTK gene that causes severe vision impairment in a patient.

  3. Utilizing an ex vivo co-cultivation approach to model key cellular and molecular events found in vivo during infarction, cardiomyocyte phagocytosis was found to be inefficient, in part due to myocyte-induced shedding of macrophage MERTK

  4. Upon differentiation of these iPSC towards RPE (show RPE Proteins), patient-specific RPE (show RPE Proteins) cells exhibited defective phagocytosis, a characteristic phenotype of MERTK deficiency observed in human patients and animal models

  5. The current study demonstrates the contribution of the TAM (show CCNA1 Proteins) receptor MerTK to the phagocytosis of myelin by human adult microglia and monocyte-derived macrophages.

  6. One of the associated variants was also found to be linked with increased expression of MERTK in monocytes and higher expression of MERTK was associated with either increased or decreased risk of developing MS, dependent upon HLA-DRB1 (show HLA-DRB1 Proteins)*15:01 status.

  7. Combined Mertk (and Mfge8 (show MFGE8 Proteins)) deficiency in macrophages blunted VEGFA (show VEGFA Proteins) release from infarcted hearts.

  8. Studies indicate that c-Mer receptor tyrosine kinase MERTK mutations cause retinal degenerations.

  9. Data indicate that AAV2-VMD2 (show BEST1 Proteins)-c-mer proto-oncogene (show RAB1A Proteins) protein (hMERTK) provided up to 6.5 months photoreceptor rescue in the RCS (show ARPP21 Proteins) rat, and also had a major protective effect in Mertk-null mice.

  10. Data show that activated AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) limits retinal pigment epithelial cells (RPE (show RPE Proteins)) phagocytic activity by abolishing retinal photoreceptor cell outer segment (POS)-induced activation of c-mer proto-oncogene tyrosine kinase (MerTK).

Mouse (Murine) C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) interaction partners

  1. Signaling through the Mer (show ERH Proteins) proto-oncogene (show RAB1A Proteins) tyrosine kinase (show TYRO3 Proteins) (MerTK) receptor in cultured macrophages and in sterile inflammation in vivo promotes specialized proresolving mediator (SPM (show NPC1 Proteins)) biosynthesis by a mechanism involving an increase in the cytoplasmic:nuclear ratio of a key SPM (show NPC1 Proteins) biosynthetic enzyme, 5-lipoxygenase (show ALOX5 Proteins).

  2. These studies define the clearance of infected, apoptotic neutrophils by dendritic cells and Mer (show ERH Proteins) receptor signaling as central to the early immune evasion strategies of L. major.

  3. Tyro3 (show TYRO3 Proteins) gene dosage modulates Mertk-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 (show TYRO3 Proteins) in RPE (show RPE Proteins) phagocytosis, and suggest that an eQTL (show EQTN Proteins) can modify a recessive Inherited photoreceptor degenerations.

  4. Activation of Mertk synergized with interferon-beta (show IFNB1 Proteins) to tighten cell junctions and prevent virus transit across brain microvascular endothelial cells.

  5. results establish TAM (show CCNA1 Proteins) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease

  6. Loss of Mertk alters expression of micrornas in retinal pigment epithelial cells.

  7. These results suggest that TAM (show CCNA1 Proteins) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.

  8. Mertk deficiency affects not only phagocytosis but also cell shape and migration

  9. The results indicate that Axl (show AXL Proteins) and Mer (show ERH Proteins) receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.

  10. Enhanced Mer signaling during the recovery phase increases the abundance and activity of LXR to inactivate the inflammatory response in macrophages

MERTK Protein Profile

Protein Summary

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Alternative names and synonyms associated with MERTK

  • c-mer proto-oncogene tyrosine kinase (MERTK)
  • c-mer proto-oncogene tyrosine kinase (LOC100219161)
  • c-mer proto-oncogene tyrosine kinase (mertk)
  • c-mer proto-oncogene tyrosine kinase (Mertk)
  • C-EYK protein
  • c-mer protein
  • DKFZp469D2215 protein
  • Eyk protein
  • Mer protein
  • MERTK protein
  • nmf12 protein
  • Nyk protein
  • rdy protein
  • RP38 protein
  • si:ch1073-268l12.2 protein

Protein level used designations for MERTK

c-eyk proto-oncogene , tyrosine-protein kinase Mer , c-mer proto-oncogene tyrosine kinase , MER receptor tyrosine kinase , tyrosine-protein kinase Mer-like , STK kinase , proto-oncogene c-Mer , receptor tyrosine kinase MerTK , Tyro 12 , proto-oncogene tyrosine-protein kinase Mer , Receptor tyrosine tinase gene probably the gene for Rdy , proto-oncogene tyrosine-protein kinase MER , retinal dystrophy

395836 Gallus gallus
459492 Pan troglodytes
483060 Canis lupus familiaris
504429 Bos taurus
698330 Macaca mulatta
100171862 Pongo abelii
100219161 Taeniopygia guttata
100322133 Danio rerio
100476239 Ailuropoda melanoleuca
10461 Homo sapiens
17289 Mus musculus
65037 Rattus norvegicus
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