Browse our MERTK Proteins (MERTK)

Full name:
C-Mer Proto-Oncogene Tyrosine Kinase Proteins (MERTK)
On are 25 C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) Proteins from 10 different suppliers available. Additionally we are shipping MERTK Antibodies (213) and MERTK Kits (22) and many more products for this protein. A total of 277 MERTK products are currently listed.
C-EYK, c-mer, DKFZp469D2215, Eyk, Mer, MERTK, nmf12, Nyk, rdy, RP38, si:ch1073-268l12.2
list all proteins Gene Name GeneID UniProt
MERTK 10461 Q12866
MERTK 17289 Q60805
MERTK 65037 P57097

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MERTK Proteins (MERTK) by Origin

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Top referenced MERTK Proteins

  1. Mouse (Murine) MERTK Protein expressed in Baculovirus infected Insect Cells - ABIN2007918 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)
    Show all 3 references for 2007918

  2. Mouse (Murine) MERTK Protein expressed in Human Cells - ABIN2007915 : Gal, Li, Thompson, Weir, Orth, Jacobson, Apfelstedt-Sylla, Vollrath: Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. in Nature genetics 2000 (PubMed)
    Show all 3 references for 2007915

  3. Human MERTK Protein expressed in Baculovirus infected Insect Cells - ABIN2002536 : Oppermann, Gnad, Olsen, Hornberger, Greff, Kéri, Mann, Daub: Large-scale proteomics analysis of the human kinome. in Molecular & cellular proteomics : MCP 2009 (PubMed)
    Show all 3 references for 2002536

More Proteins for MERTK Interaction Partners

Human C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) interaction partners

  1. Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 (show TYRO3 Proteins) and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 (show TYRO3 Proteins) and Mer expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 (show TYRO3 Proteins) and Mer mRNA and increased shedding of sTyro3 and sMer.

  2. evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (show TXK Proteins) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.

  3. Small molecule and antibody inhibitors of AXL (show AXL Proteins) and MER have recently been described, and some of these have already entered clinical trials. The optimal design of treatment strategies to maximize the clinical benefit of these AXL (show AXL Proteins) and MER targeting agents are discussed in relation to the different cancer types and the types of resistance encountered.

  4. A 48 bp insertion sequence was buried within the breakpoint; 18 bps shared homology to MIR4435-2HG and LINC00152, and 30 bp mapped to MERTK. The deletion cosegregated with arRP in the family.

  5. In this paper, we review the biology of the Gas6 (show GAS6 Proteins)/Tyro3 (show TYRO3 Proteins), Axl (show AXL Proteins), and MerTK(collectively named TAM (show CCNA1 Proteins) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .

  6. The rs4374383 AA genotype, associated with lower intrahepatic expression of MERTK, is protective against F2-F4 fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).

  7. We report a novel missense mutation (c.3G>A, p.0?) in the MERTK gene that causes severe vision impairment in a patient.

  8. Utilizing an ex vivo co-cultivation approach to model key cellular and molecular events found in vivo during infarction, cardiomyocyte phagocytosis was found to be inefficient, in part due to myocyte-induced shedding of macrophage MERTK

  9. Upon differentiation of these iPSC towards RPE (show RPE Proteins), patient-specific RPE (show RPE Proteins) cells exhibited defective phagocytosis, a characteristic phenotype of MERTK deficiency observed in human patients and animal models

  10. The current study demonstrates the contribution of the TAM (show CCNA1 Proteins) receptor MerTK to the phagocytosis of myelin by human adult microglia and monocyte-derived macrophages.

Mouse (Murine) C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) interaction partners

  1. evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (show TYRO3 Proteins) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.

  2. these results suggest, for the first time, that MerTK is an intracellular negative feedback regulator that inhibits the inflammatory response of lipoteichoic acid -stimulated macrophages

  3. the reciprocal activation of Axl (show AXL Proteins) and Mer (show ERH Proteins) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.

  4. Reduced transcription of Mertk, rather than differences in MERTK protein structure, determines the reduced efficiency of apoptotic cell clearance in the Aath4a(DBA/DBA (show RPS19 Proteins)) mice, which, in turn, contributes to their increased susceptibility to atherosclerosis.

  5. Axl (show AXL Proteins), Mertk and Tyro3 (show TYRO3 Proteins) receptors are not required for Zika virus entry and infection.

  6. Signaling through the Mer (show ERH Proteins) proto-oncogene (show RAB1A Proteins) tyrosine kinase (show TYRO3 Proteins) (MerTK) receptor in cultured macrophages and in sterile inflammation in vivo promotes specialized proresolving mediator (SPM (show NPC1 Proteins)) biosynthesis by a mechanism involving an increase in the cytoplasmic:nuclear ratio of a key SPM (show NPC1 Proteins) biosynthetic enzyme, 5-lipoxygenase (show ALOX5 Proteins).

  7. These studies define the clearance of infected, apoptotic neutrophils by dendritic cells and Mer (show ERH Proteins) receptor signaling as central to the early immune evasion strategies of L. major.

  8. Tyro3 (show TYRO3 Proteins) gene dosage modulates Mertk-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 (show TYRO3 Proteins) in RPE (show RPE Proteins) phagocytosis, and suggest that an eQTL (show EQTN Proteins) can modify a recessive Inherited photoreceptor degenerations.

  9. Activation of Mertk synergized with interferon-beta (show IFNB1 Proteins) to tighten cell junctions and prevent virus transit across brain microvascular endothelial cells.

  10. results establish TAM (show CCNA1 Proteins) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease

MERTK Protein Profile

Protein Summary

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Alternative names and synonyms associated with MERTK

  • c-mer proto-oncogene tyrosine kinase (MERTK)
  • c-mer proto-oncogene tyrosine kinase (LOC100219161)
  • c-mer proto-oncogene tyrosine kinase (mertk)
  • c-mer proto-oncogene tyrosine kinase (Mertk)
  • C-EYK protein
  • c-mer protein
  • DKFZp469D2215 protein
  • Eyk protein
  • Mer protein
  • MERTK protein
  • nmf12 protein
  • Nyk protein
  • rdy protein
  • RP38 protein
  • si:ch1073-268l12.2 protein

Protein level used designations for MERTK

c-eyk proto-oncogene , tyrosine-protein kinase Mer , c-mer proto-oncogene tyrosine kinase , MER receptor tyrosine kinase , tyrosine-protein kinase Mer-like , STK kinase , proto-oncogene c-Mer , receptor tyrosine kinase MerTK , Tyro 12 , proto-oncogene tyrosine-protein kinase Mer , Receptor tyrosine tinase gene probably the gene for Rdy , proto-oncogene tyrosine-protein kinase MER , retinal dystrophy

395836 Gallus gallus
459492 Pan troglodytes
483060 Canis lupus familiaris
504429 Bos taurus
698330 Macaca mulatta
100171862 Pongo abelii
100219161 Taeniopygia guttata
100322133 Danio rerio
100476239 Ailuropoda melanoleuca
10461 Homo sapiens
17289 Mus musculus
65037 Rattus norvegicus
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