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anti-Human PDGFB Antibodies:
anti-Mouse (Murine) PDGFB Antibodies:
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Human Polyclonal PDGFB Primary Antibody for IF (p), IHC (p) - ABIN725990
Morita, Furube, Mannari, Okuda, Tatsumi, Wanaka, Miyata: Vascular endothelial growth factor-dependent angiogenesis and dynamic vascular plasticity in the sensory circumventricular organs of adult mouse brain. in Cell and tissue research 2015
Show all 4 Pubmed References
Human Polyclonal PDGFB Primary Antibody for WB - ABIN3043599
Hong, Hong, Chen, Wang, Hong: Investigation of the protective effect of erythropoietin on spinal cord injury in rats. in Experimental and therapeutic medicine 2012
Show all 2 Pubmed References
Human Monoclonal PDGFB Primary Antibody for CyTOF, FACS - ABIN258832
Schito, Rey, Tafani, Zhang, Wong, Russo, Russo, Semenza: Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. in Proceedings of the National Academy of Sciences of the United States of America 2012
Human Polyclonal PDGFB Primary Antibody for IHC, IHC (p) - ABIN4344540
Hartleben, Widmeier, Suhm, Worthmann, Schell, Helmstädter, Wiech, Walz, Leitges, Schiffer, Huber: aPKCλ/ι and aPKCζ contribute to podocyte differentiation and glomerular maturation. in Journal of the American Society of Nephrology : JASN 2013
Human Polyclonal PDGFB Primary Antibody for IHC (fro), IHC (p) - ABIN115467
Harrison, Kharbanda, Cunningham, McLellan, Hayes: Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury. in Journal of clinical pathology 1989
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Human Polyclonal PDGFB Primary Antibody for IHC (fro), IHC (p) - ABIN115468
van Steensel, Paridaens, van Meurs, van Hagen, van den Bosch, Kuijpers, Drexhage, Hooijkaas, Dik: Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves' ophthalmopathy. in The Journal of clinical endocrinology and metabolism 2012
Human Polyclonal PDGFB Primary Antibody for IHC, ELISA - ABIN1585009
Lim, Moon, Shin, Kim, Cho, Kim, Park, Choi, Ko, Chung, Lee, Jang, Kim, Park: Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats. in Cardiovascular research 2011
High PDGFB expression is associated with gastric cancer.
We observed that regenerating and necrotic muscle fibers in muscle biopsy samples from Duchenne muscular dystrophy (show DMD Antibodies) patients expressed PDGF (show PDGFA Antibodies)-BB.
Elevated PDGFB expression was noted in 29% of patients with papillary renal cell carcinoma (show MOK Antibodies).
Insulin (show INS Antibodies) treatment caused sustained Akt (show AKT1 Antibodies) activity, whereas EGF (show EGF Antibodies) or PDGF (show PDGFA Antibodies)-AA promoted transient signaling; PDGF (show PDGFA Antibodies)-BB produced sustained responses at higher concentrations.Transient responses to EGF (show EGF Antibodies) were caused by negative feedback at the receptor level, as a second treatment yielded minimal responses, whereas parallel exposure to IGF-I (show IGF1 Antibodies) caused full Akt (show AKT1 Antibodies) activation
high-throughput affinity plasma proteomic profiling is a valuable research strategy to identify potential candidate biomarkers for thrombosis-related disorders, and our study suggests a novel association of PDGFB plasma levels with venous thromboembolism.
High PDGFB expression is associated with glioma.
A cell-autonomous positive-signaling circuit is associated with the PDGF (show PDGFA Antibodies)-NO-ID4 (show ID4 Antibodies)-regulatory axis in glioblastoma cells.
SphK1 (show SPHK1 Antibodies) is regulated by PDGF (show PDGFA Antibodies)-BB in pulmonary artery smooth muscle cells via the transcription factor Egr-1 (show EGR1 Antibodies), promoting cell proliferation.
PDGF (show PDGFA Antibodies)-BB regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner.
Low concentration of PDGF (show PDGFA Antibodies)-AB showed synergism with IFN-alpha (show IFNA Antibodies) in IFN-beta (show IFNB1 Antibodies) and -gamma induction.
intrinsic PDGF-B expressed in the spinal cord may play an essential role in neuroregulation in primates following cord hemisection
Study suggest that PDGF-B is induced by hypoxia and protects against apoptosis via the PI3K/Akt (show AKT1 Antibodies)/Stat3 (show STAT3 Antibodies) signaling pathway.
PDGF-B transcription is increased by Nuclear Factor Kappa B
up-regulated by Angiotensin II in retinal pericytes; results suggest that Ang II (show AGT Antibodies)-type 1 receptor interaction could stimulate PDGF-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation
PEDF promotes growth of pericytes through autocrine production of PDGFB.
Hypoxia enhances PDGF-B paracrine interactions between glomerular endothelial and mesangial cells.
Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS (show ROS1 Antibodies), NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF (show VEGFA Antibodies), FGF-2 (show FGF2 Antibodies) and PDGF (show PDGFA Antibodies)-BB.
PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
data suggest that the stronger fibrotic effect generated by Pdgfa (show PDGFA Antibodies) overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells
loss-of-function mutations in PDGFB or PDGFRB (show PDGFRB Antibodies) cause Primary Familial Brain Calcification.
Results suggest that regional Pax3 (show PAX3 Antibodies) expression not only marks a novel subset of High-grade Brainstem Glioma but also contributes to PDGF-B-induced brainstem gliomagenesis
High PDGFB expression is associated with liver fibrosis.
Increased expression of STAT5b (show STAT5B Antibodies) + PDGFB led to increased expression of downstream STAT5b (show STAT5B Antibodies) targets.
Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2 (show ABCB4 Antibodies)-null mice.
The endogenous levels of PDGF (show PDGFA Antibodies)-BB, increases CD31 (show PECAM1 Antibodies)(hi)endomucin (show EMCN Antibodies)(hi) vessel number and stimulates bone formation in ovariectomy mice.
These findings thus implicate a novel role of PDGF (show PDGFA Antibodies)-BB in the migration of pericytes, resulting in loss of pericyte coverage from the endothelium with a subsequent breach of the blood-brain barrier
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
PDGF subunit B
, PDGF, B chain
, platelet-derived growth factor 2
, platelet-derived growth factor B chain
, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
, platelet-derived growth factor subunit B
, platelet-derived growth factor, beta polypeptide (oncogene SIS)
, proto-oncogene c-Sis
, platelet-derived growth factor B
, v-sis platelet-derived growth factor beta polypeptide (simian sarcoma viral oncogene homolog)
, platelet-derived growth factor beta polypeptide
, Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
, pdgf protein
, platelet derived growth factor, B polypeptide
, platelet-derived growth factor B subunit