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Browse our anti-TEK (TEK) Antibodies

Full name:
anti-TEK Tyrosine Kinase, Endothelial Antibodies (TEK)
On www.antibodies-online.com are 392 TEK Tyrosine Kinase, Endothelial (TEK) Antibodies from 31 different suppliers available. Additionally we are shipping TEK Kits (69) and TEK Proteins (40) and many more products for this protein. A total of 521 TEK products are currently listed.
Synonyms:
AA517024, CD202B, DKFZp469E064, Hyk, TEK, Tie-2, tie2, VMCM, VMCM1
list all antibodies Gene Name GeneID UniProt
TEK 21687  
TEK 7010 Q02763
TEK 89804  

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Most Popular Reactivities for anti-TEK (TEK) Antibodies

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anti-Mouse (Murine) TEK Antibodies:

anti-Human TEK Antibodies:

anti-Rat (Rattus) TEK Antibodies:

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Top referenced anti-TEK Antibodies

  1. Human Polyclonal TEK Primary Antibody for EIA - ABIN358489 : Cascone, Audero, Giraudo, Napione, Maniero, Philips, Collard, Serini, Bussolino: Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1. in Blood 2003 (PubMed)
    Show all 5 references for ABIN358489

  2. Human Polyclonal TEK Primary Antibody for EIA, IHC (p) - ABIN4620395 : DeBusk, Chen, Nishishita, Chen, Thomas, Lin: Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. in Arthritis and rheumatism 2003 (PubMed)
    Show all 5 references for ABIN4620395

  3. Human Monoclonal TEK Primary Antibody for EIA, FACS - ABIN155165 : Harris, Reusch, Barleon, Hang, Dobbs, Marme: Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2001 (PubMed)
    Show all 4 references for ABIN155165

  4. Human Monoclonal TEK Primary Antibody for IHC (fro), WB - ABIN967565 : Dumont, Gradwohl, Fong, Puri, Gertsenstein, Auerbach, Breitman: Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. in Genes & development 1994 (PubMed)
    Show all 4 references for ABIN967565

  5. Human Monoclonal TEK Primary Antibody for EIA, FACS - ABIN155164 : Chin, Greenman, Reusch, Gardiner, Marme, Monson: Changes in serum soluble VEGFR-1 and Tie-2 receptors in colorectal cancer patients following surgical resections. in Anticancer research 2004 (PubMed)
    Show all 3 references for ABIN155164

  6. Human Polyclonal TEK Primary Antibody for IHC, ELISA - ABIN1532488 : Ziegler, Bird, Schneringer, Schooley, Baum: Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta. in Oncogene 1993 (PubMed)
    Show all 2 references for ABIN1532488

  7. Human Polyclonal TEK Primary Antibody for IF, ELISA - ABIN1531402 : Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: The consensus coding sequences of human breast and colorectal cancers. ... in Science (New York, N.Y.) 2006 (PubMed)
    Show all 2 references for ABIN1531402

  8. Human Monoclonal TEK Primary Antibody for IHC (p), IHC - ABIN258840 : Rodrigues-Pinto, Berry, Piper-Hanley, Hanley, Richardson, Hoyland: Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord-specific markers during early human intervertebral disc development. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016 (PubMed)

  9. Mouse (Murine) Monoclonal TEK Primary Antibody for ICC, FACS - ABIN259889 : Fernandez-Ruiz, Kawa, Berasain, Iñiguez, Schmitz, Martinez-Ansó, Iñarrairaegui, Herrero, Sangro, DAvola, Quiroga, Qian, Prieto: Treatment of murine fulminant hepatitis with genetically engineered endothelial progenitor cells. in Journal of hepatology 2011 (PubMed)

More Antibodies against TEK Interaction Partners

Mouse (Murine) TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. Hydroxysafflor yellow A promotes angiogenesis in ischemic hindlimb via the angiopoi (show ANGPT1 Antibodies)etin 1/ Tie-2 signaling pathway.

  2. TBMS1 further stimulated the proteasomal degradation of vascular endothelial growth factor receptor-2 (VEGFR2 (show KDR Antibodies)) and Tie2 in endothelial cells, which down-regulated AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling.

  3. results implicate common genetic variation at the TIE2 locus as a determinant of vascular leak-related clinical outcomes from common infections, suggesting new tools to identify individuals at unusual risk for deleterious complications of infection

  4. the results suggest that an increased level of TNF-alpha (show TNF Antibodies) together with concomitant upregulation of Tie2/Angiopoietin signaling have critical roles in severe dengue infection.

  5. Data support an interactive model of Tie1 (show TIE1 Antibodies) and Tie2 function, in which dynamically regulated Tie1 (show TIE1 Antibodies) versus Tie2 expression determines the net positive or negative effect of Tie1 (show TIE1 Antibodies) on Tie2 signaling.

  6. These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (show VCAM1 Antibodies).

  7. Report accelerated lung regeneration by platelet-rich plasma extract through Lrp5 (show LRP5 Antibodies)/Tie2 pathway.

  8. Rapamycin improves TIE2-mutated venous malformation

  9. an EPC (show TCF21 Antibodies) SDF-1 (show CXCL12 Antibodies)/CXCR4 (show CXCR4 Antibodies) axis plays an important role in bone fracture healing using Tie2-Cre(ER) CXCR4 (show CXCR4 Antibodies) conditional knockout mice.

  10. Immunohistological analysis of the tumors showed that Tie2-dependent a6 gene deletion was associated with reduced tumor vascularization and with reduced infiltration of proangiogenic Tie2-expressing macrophages

Human TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand (show ANGPT2 Antibodies) Ang-1 (show ANGPT1 Antibodies), but not the receptor binding domain of Ang-2 (show ANGPT2 Antibodies), can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK (show MAPK1 Antibodies) signaling in the presence of both Ang-1 (show ANGPT1 Antibodies) and fibronectin (show FN1 Antibodies)

  2. Activation of Tie2 by subcutaneous injections of AKB-9778 combined with suppression of vascular endothelial growth factor (VEGF) causes a significantly greater reduction in Diabetic macular edema than that seen with suppression of VEGF alone.

  3. We could therefore conclude that angiogenesis is an important event in the development of common skin warts, and the upregulation of both Ang1 (show ANGPT1 Antibodies) and -2 and their binding receptor Tie2 may play a role in the angiogenesis associated with the development of these lesions.

  4. Calcium/calmodulin (show CALM1 Antibodies)-dependent negative regulation of Tie2 can be used as an inhibitory signal for vessel growth and branching to build proper vessel architecture during embryonic development.

  5. Tie2 in combination with Ca125 (show MUC16 Antibodies) provides superior information to clinicians on progressive disease in patients with VEGFi-treated ovarian cancers

  6. Hydroxysafflor yellow A promotes angiogenesis in HUVEC cells via the angiopoietin 1 (show ANGPT1 Antibodies)/ Tie-2 signaling pathway.

  7. These results suggest that COMP (show COMP Antibodies)-Ang1 (show ANGPT1 Antibodies) enhances survival and proliferation of human PLFs through the activation of Tie2-mediated signaling, where PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and MAPK (show MAPK1 Antibodies)-c-Jun (show JUN Antibodies) signaling pathways act as downstream effectors.

  8. Exercise therapy increased levels of proangiogenic TIE-2 monocytes and circulating angiogenic cells in patients with peripheral arterial disease.

  9. These results suggested that IL-35 restrains rheumatoid arthritis angiogenesis and inflammation by downregulating basal and VEGF (show VEGFA Antibodies)-induced Ang2 (show ANGPT2 Antibodies) secretion as well as disrupting Ang2 (show ANGPT2 Antibodies)/Tie2 signal transduction.

  10. High Ang 1 (show ANGPT1 Antibodies) expression in hilar cholangiocarcinoma and infiltration of TIE2-expressing monocytes (TEMs) defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Low Ang 2 (show ANGPT2 Antibodies) levels tended to inversely correlate with TEMs invasion.

Cow (Bovine) TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.

Zebrafish TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. observations demonstrate that Tie2 is an important regulator of tip cell behaviors

  2. Tie-1 (show TIE1 Antibodies) and Tie-2 are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.

TEK Antigen Profile

Antigen Summary

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations\; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Alternative names and synonyms associated with TEK

  • TEK tyrosine kinase, endothelial (TEK) antibody
  • TEK tyrosine kinase, endothelial (LOC100356675) antibody
  • TEK tyrosine kinase, endothelial (tek) antibody
  • endothelial-specific receptor tyrosine kinase (Tek) antibody
  • TEK tyrosine kinase, endothelial (Tek) antibody
  • AA517024 antibody
  • CD202B antibody
  • DKFZp469E064 antibody
  • Hyk antibody
  • TEK antibody
  • Tie-2 antibody
  • tie2 antibody
  • VMCM antibody
  • VMCM1 antibody

Protein level used designations for TEK

growth factor receptor Tie2/Tek , TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) , Angiopoietin-1 receptor , TEK tyrosine kinase, endothelial , angiopoietin-1 receptor-like , STK1 , angiopoietin-1 receptor , endothelial tyrosine kinase , mTIE2 , p140 TEK , tunica interna endothelial cell kinase , tyrosine kinase with Ig and EGF homology domains-2 , tyrosine-protein kinase receptor TEK , tyrosine-protein kinase receptor TIE-2 , hTIE2 , soluble TIE2 variant 1 , soluble TIE2 variant 2 , protein-tyrosine kinase Tie2 , endothelial-specific receptor tyrosine kinase , tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2 , endothelium-specific receptor tyrosine kinase 2 , tyrosine-protein kinase receptor Tie-2

GENE ID SPECIES
403714 Canis lupus familiaris
465028 Pan troglodytes
707455 Macaca mulatta
100174302 Pongo abelii
100356675 Oryctolagus cuniculus
100408334 Callithrix jacchus
100492432 Xenopus (Silurana) tropicalis
100606897 Nomascus leucogenys
21687 Mus musculus
7010 Homo sapiens
396729 Sus scrofa
89804 Rattus norvegicus
280939 Bos taurus
30747 Danio rerio
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