TEK antibody (AA 758-789)
Quick Overview for TEK antibody (AA 758-789) (ABIN3029103)
Target
See all TEK AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 758-789
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Purpose
- TIE2 Antibody / TEK
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Cross-Reactivity (Details)
- Expected species reactivity: Bovine
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Purification
- Purified
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Immunogen
- A portion of amino acids 758-789 from the human protein was used as the immunogen for this TIE2 antibody.
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Isotype
- Ig Fraction
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Application Notes
- Titration of the TIE2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Aliquot the TIE2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
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Alternative Name
- TIE2
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Background
- The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations, the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
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UniProt
- Q02763
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Pathways
- RTK Signaling, Growth Factor Binding
Target
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