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TEK Products

(TEK Tyrosine Kinase, Endothelial (TEK))
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations\; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008].

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Featured TEK Categories

TEK Antibodies

High quality antibodies with extensive validation data.

TEK ELISA Kits

Reliable ELISA kits for a wide range of species.

TEK Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TEK Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (5)
Cat. No. ABIN3029103
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (5)
Cat. No. ABIN1327048
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (3)
Cat. No. ABIN520823
Quantity 100 μg
Datasheet Datasheet

Recommended TEK ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
Cat. No. ABIN6730884
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6959878
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN411357
Quantity 96 tests
Datasheet Datasheet

Recommended TEK Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN6992355
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (2)
Cat. No. ABIN5570126
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7198206
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our TEK products

Idowu, Etzrodt, Seeliger, Bolanos-Palmieri, Thamm, Haller, David: "Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis." in: eLife, Vol. 9, (2020) (PubMed).

Liu, Tang, Li, Pu, Yang, Chang: "PADI4 stimulates esophageal squamous cell carcinoma tumor growth and up-regulates CA9 expression." in: Molecular carcinogenesis, Vol. 58, Issue 1, pp. 66-75, (2019) (PubMed).

Shao, Sottoriva, Palasiewicz, Zhang, Hyun, Soni, Paik, Gao, Cuervo, Malik, Rehman, Lucas, Pajcini: "A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche." in: Haematologica, (2019) (PubMed).

Guo, Si, Zhou, Wang, Zhang, Leung, Xu, Zhang: "Decreased PECAM1-mediated TGF-β1 expression in the mid-secretory endometrium in women with recurrent implantation failure." in: Human reproduction (Oxford, England), Vol. 33, Issue 5, pp. 832-843, (2018) (PubMed).

Triantafyllou, Pop, Possamai, Wilhelm, Liaskou, Singanayagam, Bernsmeier, Khamri, Petts, Dargue, Davies, Tickle, Yuksel, Patel, Abeles, Stamataki, Curbishley, Ma, Wilson, Coen, Woollard, Quaglia et al.: "MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. ..." in: Gut, Vol. 67, Issue 2, pp. 333-347, (2018) (PubMed).

Higgins, De Ceunynck, Kellum, Chen, Gu, Chaudhry, Schulman, Libermann, Lu, Shapiro, Christiani, Flaumenhaft, Parikh: "Tie2 protects the vasculature against thrombus formation in systemic inflammation." in: The Journal of clinical investigation, Vol. 128, Issue 4, pp. 1471-1484, (2018) (PubMed).

Ko, Kim: "Cooperation between ZEB2 and Sp1 promotes cancer cell survival and angiogenesis during metastasis through induction of survivin and VEGF." in: Oncotarget, Vol. 9, Issue 1, pp. 726-742, (2018) (PubMed).

Kato, Diéguez-Hurtado, Park, Hong, Kato-Azuma, Adams, Stehling, Trappmann, Wrana, Koh, Adams: "Pulmonary pericytes regulate lung morphogenesis." in: Nature communications, Vol. 9, Issue 1, pp. 2448, (2018) (PubMed).

Lu, Tai, Ai, Gessler, Su, Yao, Zheng, Zamore, Xu, Gao: "Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs." in: Molecular therapy. Nucleic acids, Vol. 10, pp. 349-360, (2018) (PubMed).

Trieu, van Meurs, van Leeuwen, Van Slyke, Hoang, Geeraedts, Boer, van den Brom: "Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock." in: Anesthesiology, Vol. 128, Issue 2, pp. 361-374, (2018) (PubMed).

Synonyms and alternative names related to TEK

TEK receptor tyrosine kinase (TEK), angiopoietin-1 receptor (LOC100408334), TEK receptor tyrosine kinase (tek), TEK receptor tyrosine kinase (Tek), TEK tyrosine kinase, endothelial (tek), AA517024, Cd202b, CD202B, DKFZp469E064, Hyk, TEK, tie-2, TIE-2, Tie-2, Tie2, TIE2, tie2, VMCM, VMCM1

Protein level used designations for TEK

  • growth factor receptor Tie2/Tek
  • TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)
  • Angiopoietin-1 receptor
  • TEK tyrosine kinase, endothelial
  • angiopoietin-1 receptor-like
  • STK1
  • angiopoietin-1 receptor
  • endothelial tyrosine kinase
  • mTIE2
  • p140 TEK
  • tunica interna endothelial cell kinase
  • tyrosine kinase with Ig and EGF homology domains-2
  • tyrosine-protein kinase receptor TEK
  • tyrosine-protein kinase receptor TIE-2
  • hTIE2
  • soluble TIE2 variant 1
  • soluble TIE2 variant 2
  • protein-tyrosine kinase Tie2
  • endothelial-specific receptor tyrosine kinase
  • tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2
  • endothelium-specific receptor tyrosine kinase 2
  • tyrosine-protein kinase receptor Tie-2
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