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Expression of E-cadherin was significantly associated with the diffuse-type familial EOGCs and early stage, whereas expression of ERalpha (show ESR1 Proteins) might have little role in EOGC tumorigenesis.
Loss of TET1 (show TET1 Proteins) expression facilitates colon cancer cell migration via H3K27me3-mediated repression of E-cadherin expression.
Immunostaining revealed that NKA (show TAC1 Proteins) was co-localized with E-cadherin in the glands of the gastric epithelium. Both NKA (show TAC1 Proteins) activity and alpha1-isoform protein expression were reduced in the study group (P < 0.05), indicating impaired NKA (show TAC1 Proteins) functions
The expression of E-cad and VEGF and their relationship with clinical features of triple-negative breast cancer (TNBC) suggest that Uygur patients might have different prognostic factors as compared with Han patients. The expression of E-cad was negatively correlated with lymph node metastasis, stage, and histological grade.
CDH1 single-nucleotide polymorphisms role in susceptibility to non-small cell lung cancer
ZIP6 (show SLC39A6 Proteins) deficiency disturbs intracellular Zn2+ homeostasis, leading to increased cell survival in hypoxia and reduced E-cadherin expression, indicating that decreased ZIP6 (show SLC39A6 Proteins) expression is strongly associated with resistance to hypoxia.
Results show that mesenchymal N-cadherin (show CDH2 Proteins)-expressing (Ncad (show CDH2 Proteins)+) cells and MCAs invade much more efficiently than E-cadherin-expressing (Ecad+) cells. Data emphasize the role of Ncad (show CDH2 Proteins) in intraperitoneal seeding of EOC and provide the rationale for future studies targeting Ncad (show CDH2 Proteins) in preclinical models of epithelial ovarian cancer metastasis.
Study demonstrated that down-regulation of E-cadherin contributes to epithelial-to-mesenchymal transition-mediated chemo-resistance of prostate cancer.
Results suggest that epigenetic aberration of the e-cadherin gene (CDH1) may occur in the endometrium of patients with fibroids, which may be associated with E-cadherin protein expression in endometrial tissue.
E-cadherin genetic variants control disease severity and progression and could be a marker of disease outcome.
In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin (show CDH2 Proteins) is required for lens fiber growth
These data indicate that emi1 (show FBXO5 Proteins) deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.
without Chp (show CHP Proteins) signaling, E-cadh shifts to intracellular vesicles rather than the adhesive contacts needed for directed cell movement during epiboly
Downregulation of E-cadherin gene may cause omphalocele in the Cd chick model by disrupting CRT (show CALR Proteins)-mediated Ca(2 (show CA2 Proteins)+) signaling and AJs.
analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system
cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins of zebrafish
hab/E-cadherin is necessary for the cell rearrangements that spread the teleost blastoderm over the yolk
Lgl2 (show LLGL2 Proteins) and E-cadherin act antagonistically to control the localisation of integrin alpha 6 (show ITGA6 Proteins) during the formation of hemidesmosomes in the developing epidermis
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
cadherin-mediated cell adhesion between the deep cells and enveloping layerplays a role in the epiboly movement in zebrafish
E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.
In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.
Localisation of NANOG (show NANOG Proteins), OCT4 (show POU5F1 Proteins), and E-CADHERIN in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.
The epiblast expressed epithelial markers, MUC1 (show MUC1 Proteins) and E-CADHERIN, and the pluripotency markers, DNMT3B (show DNMT3B Proteins) and CRIPTO (show TDGF1 Proteins).
E-cadherin has a role in cranial neural crest migration in Xenopus laevis
the switch from E- to N-cadherin (show CDH2 Proteins) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.
Moderate attenuation of C-cadherin function affects cell adhesion but not gastrulation.
Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.
The functional and physical relationships between PAPC, FLRT3, and C-cadherin, was investigated.
PAPC mediates these functions by down-regulating the adhesion activity of C-cadherin.
Results suggest that the basis for cell segregation during morphogenesis does not map exclusively to protein-level differences in E-, N-, or C-cadherin adhesion.
G-protein-coupled receptors control cortical actin assembly by controlling the amount of cadherin expressed on the cell surface.
Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region
Data show that the intracellular domain of PAPC (Protocadherin) interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.
PTEN loss in E-cadherin-deficient mouse mammary epithelial cells rescues apoptosis and results in development of classical invasive lobular carcinoma.
Low CDH1 expression is associated with Gastric Tumorigenesis.
These observations highlight the relevance of APC (show APC Proteins)/C cofactor Cdh1 activity during G1 to ensure an adequate supply of deoxynucleoside triphosphates to the replisome, prevent replication stress and the resulting chromosomal breaks and, ultimately, suppress tumorigenesis.
Ilk (show ILK Proteins) and ELMO2 (show ELMO2 Proteins) modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin-based adherens junctions.
JNK (show MAPK8 Proteins) signaling, which is inversely correlated with WNT4 (show WNT4 Proteins), plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin junctions between oocytes in mouse ovaries.
The expression level of E-cadherin protein was significantly decreased in fibrotic livers.
We conclude that p120ctn (show CTNND1 Proteins) is not only an adaptor and regulator of E-cadherin, but is also indispensable for proper lineage commitment.
The reduction in tumor growth in fat1 mice compared with wildtype controls may have been associated, in part, to the: i) Increased expression of Ecadherin and the reduced expression of its transcriptional repressors.
These observations suggest that the overexpression of CatE (show CTSE Proteins) interferes with neuronal differentiation of P19 (show CDKN2D Proteins) cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin (show CDH2 Proteins).
E-cadherin-mediated cell-cell contacts can modulate osteoclast-specific gene expression and prompt differentiating osteoclast precursors toward migratory and fusion activities.
Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.
E-cadherin and beta-catenin (show CTNNB1 Proteins) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells
Results describe the effect of suppression of connexin 43 (show GJA1 Proteins) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.
, cadherin 1, E-cadherin (epithelial)
, calcium-dependent adhesion protein, epithelial
, cell-CAM 120/80
, epithelial cadherin
, hypothetical protein LOC368517
, cadherin 1, epithelial
, half baked
, hypothetical protein LOC368516
, cadherin 1, type 1, E-cadherin (epithelial)
, HPT-1 cadherin
, LI cadherin
, human intestinal peptide-associated transporter HPT-1
, human peptide transporter 1
, intestinal peptide-associated transporter HPT-1
, liver-intestine cadherin
, cadherin 17, LI cadherin (liver-intestine)
, Li cadherin
, C-cadherin (EP-cadherin)
, liver cell adhesion molecule
, liver cell adhesion protein
, Epithelial cadherin