Browse our E-cadherin Proteins (CDH1)

Full name:
Cadherin 1, Type 1, E-Cadherin (Epithelial) Proteins (CDH1)
On www.antibodies-online.com are 37 Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) Proteins from 13 different suppliers available. Additionally we are shipping E-cadherin Antibodies (860) and E-cadherin Kits (83) and many more products for this protein. A total of 1007 E-cadherin products are currently listed.
Synonyms:
AA960649, arc-1, Arc1, b-cadherin, c-cadherin, cad17, cadherin-1, cadherin-17, cd324, CDH1, cdh1-a, cdh16, cdhc-A, cdhe, cdhp, dZ71B9.1, E-cad, E-cadherin, Ecad, hjmd, hpt-1, hpt1, L-CAM, lcam, LI-cadherin, pcad, si:dz180o5.1, si:dz180o5.2, Um, uvo, uvomorulin, xb-cad, XB-cadherin, XBcad, xcdh1, XTCAD-1
list all proteins Gene Name GeneID UniProt
CDH1 999 P12830
CDH1 83502 Q9R0T4
CDH1 12550 P09803

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E-cadherin Proteins (CDH1) by Origin

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Top referenced E-cadherin Proteins

  1. Rat (Rattus) E-cadherin Protein expressed in Human Cells - ABIN2009409 : Berx, Staes, van Hengel, Molemans, Bussemakers, van Bokhoven, van Roy: Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1). in Genomics 1995 (PubMed)
    Show all 5 references for 2009409

  2. Mouse (Murine) E-cadherin Protein expressed in Human Cells - ABIN2008138 : Yoshiura, Kanai, Ochiai, Shimoyama, Sugimura, Hirohashi: Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)
    Show all 5 references for 2008138

  3. Human E-cadherin Protein expressed in Human Cells - ABIN2002344 : Becker, Atkinson, Reich, Becker, Nekarda, Siewert, Höfler: E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. in Cancer research 1994 (PubMed)
    Show all 5 references for 2002344

  4. Human E-cadherin Protein expressed in HEK-293 Cells - ABIN2180987 : Agiostratidou, Muros, Shioi, Marambaud, Robakis: The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. in Journal of neurochemistry 2006 (PubMed)
    Show all 4 references for 2180987

  5. Human E-cadherin Protein expressed in Wheat germ - ABIN3013372 : Tsunematsu, Takihara, Ishimaru, Pagano, Takata, Kudo: Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis. in Nature communications 2013 (PubMed)

More Proteins for E-cadherin Interaction Partners

Human Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. E-cadherin genetic variants control disease severity and progression and could be a marker of disease outcome.

  2. Our results explored that autocrine production of human growth hormone (show GH1 Proteins) enhances cellular proliferation by the activation of nuclear factor-kappaB (65 kDa) and downregulation of E-cadherin expression.

  3. Study demonstrated that E-cadherin is a determinant molecule associated with ovarian cancer (OC) progression, dissemination and aggressiveness; showed that total and membranous E-cadherin expression levels is a specific and sensitive marker to differentiate advanced- from early-stage tumors and serous tumors from other histological types.

  4. E-cadherin re-expression and subsequent induction of NF-kappaB (show NFKB1 Proteins) signaling likely enhance energy production and cell proliferation.

  5. Low CDH1 expression is associated with colon cancer.

  6. Low CDH1 expression is associated with gastric cancer.

  7. the decrease of CDH1 transcript, corresponding to the canonical protein, and the presence of CDH1a, corresponding to an alternative isoform, are likely to perturb E-cadherin-mediated signaling and cell-cell adhesion, thus contributing to intestinal-type gastric carcinogenesis

  8. E-cadherin and beta-catenin (show CTNNB1 Proteins) expression provides discriminative prognostic power independent of conventional pathologic factors, thus further reinforcing the important role of cell adhesion molecules in the process of tumor metastasis, especially in triple-negative breast cancer (TNBC).

  9. High p120-catenin (show CTNND1 Proteins) expression is associated with skin cancer.

  10. integrin signaling potentiates transforming growth factor-beta 1 (TGF-beta1 (show TGFB1 Proteins)) dependent down-regulation of E-Cadherin expression - Important implications for epithelial to mesenchymal transition (EMT (show ITK Proteins)) in renal cell carcinoma (show MOK Proteins)

Zebrafish Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin (show CDH2 Proteins) is required for lens fiber growth

  2. These data indicate that emi1 (show FBXO5 Proteins) deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.

  3. without Chp (show CHP Proteins) signaling, E-cadh shifts to intracellular vesicles rather than the adhesive contacts needed for directed cell movement during epiboly

  4. Downregulation of E-cadherin gene may cause omphalocele in the Cd chick model by disrupting CRT (show CALR Proteins)-mediated Ca(2 (show CA2 Proteins)+) signaling and AJs.

  5. analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system

  6. cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins of zebrafish

  7. hab/E-cadherin is necessary for the cell rearrangements that spread the teleost blastoderm over the yolk

  8. Lgl2 (show LLGL2 Proteins) and E-cadherin act antagonistically to control the localisation of integrin alpha 6 (show ITGA6 Proteins) during the formation of hemidesmosomes in the developing epidermis

  9. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.

  10. cadherin-mediated cell adhesion between the deep cells and enveloping layerplays a role in the epiboly movement in zebrafish

Pig (Porcine) Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.

  2. In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.

  3. Localisation of NANOG (show NANOG Proteins), OCT4 (show POU5F1 Proteins), and E-CADHERIN in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.

  4. The epiblast expressed epithelial markers, MUC1 (show MUC1 Proteins) and E-CADHERIN, and the pluripotency markers, DNMT3B (show DNMT3B Proteins) and CRIPTO (show TDGF1 Proteins).

Xenopus laevis Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. E-cadherin has a role in cranial neural crest migration in Xenopus laevis

  2. the switch from E- to N-cadherin (show CDH2 Proteins) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.

  3. Moderate attenuation of C-cadherin function affects cell adhesion but not gastrulation.

  4. Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.

  5. The functional and physical relationships between PAPC, FLRT3, and C-cadherin, was investigated.

  6. PAPC mediates these functions by down-regulating the adhesion activity of C-cadherin.

  7. Results suggest that the basis for cell segregation during morphogenesis does not map exclusively to protein-level differences in E-, N-, or C-cadherin adhesion.

  8. G-protein-coupled receptors control cortical actin assembly by controlling the amount of cadherin expressed on the cell surface.

  9. Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region

  10. Data show that the intracellular domain of PAPC (Protocadherin) interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.

Mouse (Murine) Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. Ilk (show ILK Proteins) and ELMO2 (show ELMO2 Proteins) modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin-based adherens junctions.

  2. JNK (show MAPK8 Proteins) signaling, which is inversely correlated with WNT4 (show WNT4 Proteins), plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin junctions between oocytes in mouse ovaries.

  3. The expression level of E-cadherin protein was significantly decreased in fibrotic livers.

  4. We conclude that p120ctn (show CTNND1 Proteins) is not only an adaptor and regulator of E-cadherin, but is also indispensable for proper lineage commitment.

  5. The reduction in tumor growth in fat1 mice compared with wildtype controls may have been associated, in part, to the: i) Increased expression of Ecadherin and the reduced expression of its transcriptional repressors.

  6. These observations suggest that the overexpression of CatE (show CTSE Proteins) interferes with neuronal differentiation of P19 (show CDKN2D Proteins) cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin (show CDH2 Proteins).

  7. E-cadherin-mediated cell-cell contacts can modulate osteoclast-specific gene expression and prompt differentiating osteoclast precursors toward migratory and fusion activities.

  8. These results provide a new mechanism by which LXA4 inhibits LPS (show TLR4 Proteins)-induced ALI through Nrf2 (show NFE2L2 Proteins)-mediated E-cadherin expression

  9. Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis.

  10. E-cadherin expression regulates inflammatory mediators in macrophages.

Cow (Bovine) Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.

  2. E-cadherin and beta-catenin (show CTNNB1 Proteins) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells

  3. Results describe the effect of suppression of connexin 43 (show GJA1 Proteins) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.

E-cadherin (CDH1) Protein Profile

Protein Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Alternative names and synonyms associated with E-cadherin (CDH1)

  • cadherin 1, type 1, E-cadherin (epithelial) (CDH1)
  • si:busm1-180o5.2 (si:busm1-180o5.2)
  • cadherin 1, epithelial (cdh1)
  • cadherin 1 (Cdh1)
  • si:busm1-180o5.1 (si:busm1-180o5.1)
  • cadherin 1, type 1, E-cadherin (epithelial) (cdh1)
  • cadherin 17, LI cadherin (liver-intestine) (CDH17)
  • Cadherin-17 (cad17)
  • cadherin 17, LI cadherin (liver-intestine) (cdh17)
  • cadherin 3, type 1, P-cadherin (placental) (cdh3-a)
  • E-cadherin-like (LOC100356548)
  • Aerobic running capacity QTL 1 (Arunc1)
  • cadherin 1, type 1, E-cadherin (epithelial) (Cdh1)
  • AA960649 protein
  • arc-1 protein
  • Arc1 protein
  • b-cadherin protein
  • c-cadherin protein
  • cad17 protein
  • cadherin-1 protein
  • cadherin-17 protein
  • cd324 protein
  • CDH1 protein
  • cdh1-a protein
  • cdh16 protein
  • cdhc-A protein
  • cdhe protein
  • cdhp protein
  • dZ71B9.1 protein
  • E-cad protein
  • E-cadherin protein
  • Ecad protein
  • hjmd protein
  • hpt-1 protein
  • hpt1 protein
  • L-CAM protein
  • lcam protein
  • LI-cadherin protein
  • pcad protein
  • si:dz180o5.1 protein
  • si:dz180o5.2 protein
  • Um protein
  • uvo protein
  • uvomorulin protein
  • xb-cad protein
  • XB-cadherin protein
  • XBcad protein
  • xcdh1 protein
  • XTCAD-1 protein

Protein level used designations for CDH1

CAM 120/80 , E-Cadherin , cadherin 1, E-cadherin (epithelial) , cadherin-1 , calcium-dependent adhesion protein, epithelial , cell-CAM 120/80 , epithelial cadherin , uvomorulin , hypothetical protein LOC368517 , cadherin 1, epithelial , hab , half baked , E-cadherin , hypothetical protein LOC368516 , cadherin 1, type 1, E-cadherin (epithelial) , HPT-1 cadherin , LI cadherin , LI-cadherin , cadherin-16 , cadherin-17 , human intestinal peptide-associated transporter HPT-1 , human peptide transporter 1 , intestinal peptide-associated transporter HPT-1 , liver-intestine cadherin , xTCAD-1 , Cadherin-17 , cadherin 17, LI cadherin (liver-intestine) , Li cadherin , C-cadherin (EP-cadherin) , EP-cadherin , ARC-1 , L-CAM , liver cell adhesion molecule , liver cell adhesion protein , Epithelial cadherin

GENE ID SPECIES
999 Homo sapiens
368517 Danio rerio
114424 Danio rerio
83502 Rattus norvegicus
368516 Danio rerio
100048953 Sus scrofa
442858 Canis lupus familiaris
779546 Xenopus (Silurana) tropicalis
100294601 Ovis aries
1015 Homo sapiens
100337618 Xenopus laevis
100195084 Salmo salar
100216129 Xenopus (Silurana) tropicalis
394290 Xenopus laevis
12550 Mus musculus
282637 Bos taurus
415860 Gallus gallus
100356548 Oryctolagus cuniculus
100174439 Pongo abelii
444901 Rattus norvegicus
101095391 Felis catus
101119747 Ovis aries
100726210 Cavia porcellus
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