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Browse our E-cadherin Proteins (CDH1)

Full name:
Cadherin 1, Type 1, E-Cadherin (Epithelial) Proteins (CDH1)
On are 38 Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) Proteins from 13 different suppliers available. Additionally we are shipping E-cadherin Antibodies (785) and E-cadherin Kits (85) and many more products for this protein. A total of 934 E-cadherin products are currently listed.
AA960649, arc-1, Arc1, b-cadherin, cadherin-1, cd324, cdh1, cdh1-a, cdhc-A, cdhe, cdhp, E-cad, E-cadherin, ecad, hjmd, L-CAM, LCAM, pcad, si:dz180o5.2, Um, UVO, uvomorulin, xb-cad, XB-cadherin, XBcad, xcdh1, XTCAD-1
list all proteins Gene Name GeneID UniProt
CDH1 444901  
CDH1 12550 P09803
CDH1 999 P12830

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E-cadherin Proteins (CDH1) by Origin

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Top referenced E-cadherin Proteins

  1. Rat (Rattus) E-cadherin Protein expressed in Human Cells - ABIN2009409 : Berx, Staes, van Hengel, Molemans, Bussemakers, van Bokhoven, van Roy: Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1). in Genomics 1995 (PubMed)
    Show all 5 references for ABIN2009409

  2. Mouse (Murine) E-cadherin Protein expressed in Human Cells - ABIN2008138 : Yoshiura, Kanai, Ochiai, Shimoyama, Sugimura, Hirohashi: Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)
    Show all 5 references for ABIN2008138

  3. Human E-cadherin Protein expressed in Human Cells - ABIN2002342 : Becker, Atkinson, Reich, Becker, Nekarda, Siewert, Höfler: E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. in Cancer research 1994 (PubMed)
    Show all 5 references for ABIN2002342

  4. Human E-cadherin Protein expressed in HEK-293 Cells - ABIN2180987 : Agiostratidou, Muros, Shioi, Marambaud, Robakis: The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. in Journal of neurochemistry 2006 (PubMed)
    Show all 4 references for ABIN2180987

  5. Human E-cadherin Protein expressed in Wheat germ - ABIN3013372 : Tsunematsu, Takihara, Ishimaru, Pagano, Takata, Kudo: Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis. in Nature communications 2013 (PubMed)

More Proteins for E-cadherin Interaction Partners

Xenopus laevis Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. E-cadherin has a role in cranial neural crest migration in Xenopus laevis

  2. the switch from E- to N-cadherin (show CDH2 Proteins) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.

  3. Moderate attenuation of C-cadherin function affects cell adhesion but not gastrulation.

  4. Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.

  5. The functional and physical relationships between PAPC, FLRT3, and C-cadherin, was investigated.

  6. PAPC mediates these functions by down-regulating the adhesion activity of C-cadherin.

  7. Results suggest that the basis for cell segregation during morphogenesis does not map exclusively to protein-level differences in E-, N-, or C-cadherin adhesion.

  8. G-protein-coupled receptors control cortical actin assembly by controlling the amount of cadherin expressed on the cell surface.

  9. Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region

  10. Data show that the intracellular domain of PAPC (Protocadherin) interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.

Mouse (Murine) Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. We conclude that p120ctn (show CTNND1 Proteins) is not only an adaptor and regulator of E-cadherin, but is also indispensable for proper lineage commitment.

  2. The reduction in tumor growth in fat1 mice compared with wildtype controls may have been associated, in part, to the: i) Increased expression of Ecadherin and the reduced expression of its transcriptional repressors.

  3. These observations suggest that the overexpression of CatE (show CTSE Proteins) interferes with neuronal differentiation of P19 (show CDKN2D Proteins) cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin (show CDH2 Proteins).

  4. E-cadherin-mediated cell-cell contacts can modulate osteoclast-specific gene expression and prompt differentiating osteoclast precursors toward migratory and fusion activities.

  5. These results provide a new mechanism by which LXA4 inhibits LPS (show TLR4 Proteins)-induced ALI through Nrf2 (show NFE2L2 Proteins)-mediated E-cadherin expression

  6. Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis.

  7. E-cadherin expression regulates inflammatory mediators in macrophages.

  8. Increased expression of E-cadherin binds to and sequesters beta-catenin (show CTNNB1 Proteins) away from downstream Wnt (show WNT2 Proteins) signaling proteins.

  9. Results suggest a regulatory function of E-cadherin that modulates Nrg1 (show NRG1 Proteins) signaling and promotes Schwann cell myelin formation

  10. Both catalytic and non-catalytic APC (show APC Proteins)/C-Fzr1/Cdh1 (show FZR1 Proteins)-mediated activities of PTEN are required for stalk cells' proliferative arrest. Findings implicate the PTEN-APC (show APC Proteins)/C-Fzr1/Cdh1 (show FZR1 Proteins) hub in angiogenesis.

Human Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. A recursively partitioned mixture model of all 3 somatic alteration burden measures resulted in classes of tumors whose epigenetic and genetic burden profile were associated with the PAM50 subtype and mutations in TP53 (show TP53 Proteins), PIK3CA (show PIK3CA Proteins), and CDH1

  2. Therefore, EGF (show EGF Proteins) is suggested to induce E-cadherin down-regulation at the transcriptional level through the MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway, which might result in, at least in part, the induction of cellular morphological changes and cell migration in LoVo cells.

  3. While Claudin 1 (show CLDN7 Proteins) and 4 expression and activities of small GTPases were not affected, gamma-Secretase-mediated cleavage of E-Cadherin was attenuated by Leda-1/Pianp (show C12orf53 Proteins).

  4. Data suggest expression of ECAD (E-cadherin) in bladder cancer cell lines correlates with presence of intercellular junctions and level of PAK5 (show PAK6 Proteins) (p21 (show CDKN1A Proteins)-activated kinase PAK5 (show PAK6 Proteins) protein) expression; endogenous PAK5 (show PAK6 Proteins) is localized to intercellular junctions and interacts with ECAD; depletion of PAK5 (show PAK6 Proteins) expression reduces integrity of intercellular junctions; PAK5 (show PAK6 Proteins) mRNA levels are reduced in bladder cancer compared with normal controls.

  5. DNMT1 (show DNMT1 Proteins) down regulation mediated upregulation of CDH1 (hereafter, DNMT1 (show DNMT1 Proteins)/CDH1 loop) in presence of ectopic-excess of miR (show MLXIP Proteins)-152 prevents migration of cancer cells.

  6. This study reports the identification of a novel human E-cadherin variant mRNA produced by alternative splicing.

  7. The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02). Gene-based analyses revealed that CDH1 was responsible for the pathway association (P < 0.01),corrected P = 0.02). rs142697907 in PTPN14 (show PTPN14 Proteins) was associated with ER-positive breast cancer and rs2456773 in CDK1 (show CDK1 Proteins) with ER-negativity in case-only analysis after gene-level correction

  8. CDH1 hypermethylation may play a key role in the carcinogenesis of HCC (show FAM126A Proteins)

  9. Thrombomodulin (show THBD Proteins) up-regulated E-cadherin but down-regulated N-cadherin (show CDH2 Proteins) expression, resulting in reversal of epithelial-mesenchymal transition (EMT (show ITK Proteins)) in the lung cancer cells.

  10. The epithelial cell membrane protein E (show CRISP1 Proteins)-cadherin physically binds to PKD1 (show PKD1 Proteins) which leads to a subcellular redistribution of PKD1 (show PKD1 Proteins).

Pig (Porcine) Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.

  2. In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.

  3. Localisation of NANOG (show NANOG Proteins), OCT4 (show POU5F1 Proteins), and E-CADHERIN in porcine pre- and peri (show PLIN1 Proteins)-implantation embryos.

  4. The epiblast expressed epithelial markers, MUC1 (show MUC1 Proteins) and E-CADHERIN, and the pluripotency markers, DNMT3B (show DNMT3B Proteins) and CRIPTO (show TDGF1 Proteins).

Cow (Bovine) Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.

  2. E-cadherin and beta-catenin (show CTNNB1 Proteins) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells

  3. Results describe the effect of suppression of connexin 43 (show GJA1 Proteins) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.

Zebrafish Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) interaction partners

  1. E-cadherin mRNA coinjection demonstrated the specificity of cdh1 morpholino oligonucleotides-induced defects

  2. Results suggest that Wnt11 (show WNT11 Proteins) controls tissue morphogenesis by modulating E-cadherin-mediated cell cohesion through Rab5c (show Rab5c Proteins), a novel mechanism of Wnt (show WNT2 Proteins) signaling in gastrulation.

E-cadherin (CDH1) Protein Profile

Protein Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Alternative names and synonyms associated with E-cadherin (CDH1)

  • cadherin 3, type 1, P-cadherin (placental) (cdh3-a)
  • Aerobic running capacity QTL 1 (Arunc1)
  • cadherin 1 (Cdh1)
  • cadherin 1, type 1, E-cadherin (epithelial) (CDH1)
  • cadherin 1, type 1, E-cadherin (epithelial) (Cdh1)
  • cadherin 1, type 1, E-cadherin (epithelial) (cdh1)
  • E-cadherin-like (LOC100356548)
  • si:busm1-180o5.2 (si:busm1-180o5.2)
  • AA960649 protein
  • arc-1 protein
  • Arc1 protein
  • b-cadherin protein
  • cadherin-1 protein
  • cd324 protein
  • cdh1 protein
  • cdh1-a protein
  • cdhc-A protein
  • cdhe protein
  • cdhp protein
  • E-cad protein
  • E-cadherin protein
  • ecad protein
  • hjmd protein
  • L-CAM protein
  • LCAM protein
  • pcad protein
  • si:dz180o5.2 protein
  • Um protein
  • UVO protein
  • uvomorulin protein
  • xb-cad protein
  • XB-cadherin protein
  • XBcad protein
  • xcdh1 protein
  • XTCAD-1 protein

Protein level used designations for CDH1

C-cadherin (EP-cadherin) , EP-cadherin , cadherin 1, type 1, E-cadherin (epithelial) , ARC-1 , E-cadherin , cadherin-1 , epithelial cadherin , uvomorulin , CAM 120/80 , E-Cadherin , cadherin 1, E-cadherin (epithelial) , calcium-dependent adhesion protein, epithelial , cell-CAM 120/80 , L-CAM , liver cell adhesion molecule , liver cell adhesion protein , xTCAD-1 , Epithelial cadherin , hypothetical protein LOC368517

394290 Xenopus laevis
444901 Rattus norvegicus
12550 Mus musculus
83502 Rattus norvegicus
999 Homo sapiens
442858 Canis lupus familiaris
100048953 Sus scrofa
282637 Bos taurus
415860 Gallus gallus
101095391 Felis catus
101119747 Ovis aries
100726210 Cavia porcellus
100337618 Xenopus laevis
100174439 Pongo abelii
100356548 Oryctolagus cuniculus
368517 Danio rerio
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