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anti-Mouse (Murine) ASCL2 Antibodies:
anti-Rat (Rattus) ASCL2 Antibodies:
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Cow (Bovine) Polyclonal ASCL2 Primary Antibody for WB - ABIN2779425
Shahib, Martaadisoebrata, Kato: Detection of HASH2 (ASCL2) gene expression in gestational trophoblastic disease. in The Journal of reproductive medicine 2006
Show all 2 Pubmed References
More DNMT1 (show DNMT1 PLURAL_@45155@) mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 mRNA was present at highest levels in transgenic SCNT embryos.
Mash2 is highly conserved across species and is specifically expressed in the bovine placenta. Bovine Mash2 appears to be maternally expressed after implantation, but the paternal genome plays a role in regulating expression.
The lack of differential expression by microarray profiling of fetal tissues from swine parthenotes and control bi-parental fetuses supports lack of imprinting at ASCL2 in pigs.
Ascl2 inhibits myogenic differentiation by targeting MRFs and facilitates the generation of postnatal satellite cells.
overexpression of the imprinted Ascl2 gene has considerable consequences for placental development, specifically for the parietal trophoblast giant cell and spongiotrophoblast lineages both of which express pregnancy-related hormones.
The ascl2 forms a transcriptional switch that is both Wnt (show WNT2 Antibodies) responsive and Wnt (show WNT2 Antibodies) dependent to define stem cell identity.
Ascl2 directly initiates follicular T-helper cell development
TSSC3 (show PHLDA2 Antibodies) plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3 (show PHLDA2 Antibodies)/PI3K/AKT (show AKT1 Antibodies)/MASH2 signaling pathway.
Elevated expression of Ascl2 in a Wnt (show WNT2 Antibodies) signalling dependent manner specifically in the stem cell compartment of the intestine neither increases tumour formation nor diminishes survival in a well established intestinal tumour model, the Apc (show APC Antibodies)(min) mouse.
Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells
Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.
Mash2 gene is preferentially expressed from the paternal allele.
The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the mouse model of Beckwith-Wiedemann Syndrome.
WiNTRLINC1 interacts with TCF4 (show TCF4 Antibodies)/beta-catenin (show CTNNB1 Antibodies) to mediate the juxtaposition of its promoter with the regulatory regions of ASCL2.
Data suggest an interplay between megakaryocytic leukemia 1 (MKL1 (show MKL1 Antibodies)) and ASH2 protein to promote tumor necrosis factor alpha (TNF-alpha (show TNF Antibodies)) induced proinflammatory transcription in macrophages.
Ascl2 over-expression is associated with colorectal neoplasms.
expression of ASCL2 may identify an aggressive subgroup in lung squamous cell carcinoma
the histone methyltransferase core enzyme ASH2L (show ASH2L Antibodies) was bound at EGFR (show EGFR Antibodies) in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 (show EP300 Antibodies) was bound in samples with H3K27ac enrichment
SEMA3F (show SEMA3F Antibodies) functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 (show CXCR4 Antibodies) signaling axis.
SNAIL1 (show SNAI1 Antibodies) combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 (show EPHB3 Antibodies) tumor suppressor in colorectal cancer.
Ash2L acts in concert with P53 promoter occupancy to activate RNA Polymerase II by aiding formation of a stable transcription pre-initiation complex required for its activation.
ASCL2 gene expression is regulated by miR (show MLXIP Antibodies)-200a/b/c, miR (show MLXIP Antibodies)-141 and miR429 levels in colon cancer.
ASH2L (show ASH2L Antibodies) enhances ERalpha (show ESR1 Antibodies) expression as a coactivator of GATA3 (show GATA3 Antibodies) in breast cancers
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
achaete-scute complex-like protein 2
, achaete-scute complex homolog 2 (Drosophila)
, achaete-scute complex homolog-like 2
, achaete-scute homolog 2
, achaete scute-like protein 2
, long transient receptor potential-related channel 5
, mammalian achaete scute homolog 2
, transcription factor cash4
, achaete-scute complex-like 2
, class A basic helix-loop-helix protein 45
, mammalian achaete/scute homologue 2
, ASH2-like protein
, set1/Ash2 histone methyltransferase complex subunit ASH2