Browse our Hydroxysteroid (11-Beta) Dehydrogenase 2 Proteins (HSD11B2)

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Hydroxysteroid (11-Beta) Dehydrogenase 2 Proteins (HSD11B2)
On are 10 Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Proteins from 5 different suppliers available. Additionally we are shipping Hydroxysteroid (11-Beta) Dehydrogenase 2 Antibodies (98) and Hydroxysteroid (11-Beta) Dehydrogenase 2 Kits (22) and many more products for this protein. A total of 137 Hydroxysteroid (11-Beta) Dehydrogenase 2 products are currently listed.
11-HSD2, 11HSD2, AME, AME1, HSD2, HSD11B2, HSD11K, MGC81883, SDR9C3
list all proteins Gene Name GeneID UniProt
HSD11B2 3291 P80365
HSD11B2 15484 P51661
HSD11B2 25117 P50233

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Hydroxysteroid (11-Beta) Dehydrogenase 2 Proteins (HSD11B2) by Origin

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More Proteins for Hydroxysteroid (11-Beta) Dehydrogenase 2 Interaction Partners

Human Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. DNA sequence analysis of affected members of Apparent mineralocorticoid excess family revealed homozygous c.799A>G mutations within exon 4 of HSD11B2, corresponding to a p.T267A mutation of 11betaHSD2.

  2. activation of Hedgehog (show SHH Proteins) signaling is crucial for the upregulation and maintenance of 11beta-HSD2 expression in placenta

  3. Reciprocal regulation of the glucocorticoid metabolizing enzymes, 11beta-hydroxysteroid dehydrogenase types 1 and 2, is associated with steroid-responsiveness and disease remission in childhood nephrotic syndrome.

  4. Rac1 GTPase (show RACGAP1 Proteins) regulates 11beta-HSD2 expression, mineralocorticoid receptor (show NR3C2 Proteins) activation, and mineralocorticoid receptor (show NR3C2 Proteins)-mediated pro-fibrotic signaling.

  5. enhancer of zeste homolog 2 (EZH2 (show EZH2 Proteins)) accounts for the silence of 11beta-HSD2 expression via trimethylation of histone H3 (show HIST3H3 Proteins) lysine 27 at the promoter of the 11beta-HSD2 gene.

  6. Sensitivity to glucocorticoids did not appear to be mediated by changes in the expression of the beta variant of the glucocorticoid receptor or the 11-beta hydroxysteroid dehydrogenase 2 isozyme.

  7. Review of the role of HSD11B2 in pregnancy complications, fetal diseases, and later life morbidity.

  8. Since increased DNA methylation (show HELLS Proteins) in HSD11B2 and FKBP5 (show FKBP5 Proteins) are seen in a minority of bisulfite sequencing clones, these epigenetic changes, and functional consequences, may affect subpopulations of placental cells.

  9. significant positive correlation between DNA methylation of 11beta-HSD2 CpG 1 in infants and maternal sensitivity.

  10. The 11beta-HSD2 expression decreased in pre-eclamptic women of Chinese Han ethnicity, but was not interrelated with the promoter methylation status.

Pig (Porcine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. These results indicate that the effects of maternal protein restriction on placental 11beta-HSD2 expression are gender-dependent in the pig, and thyroid hormones may be involved in such effects.

  2. Postnatal ontogeny of 11beta-HSD2 gene expression is described for the first time in stress-related brain regions of domestic pigs at 7, 21, and 35 days of age.

  3. concluded that the 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 (show HSD11B1 Proteins) and 2) system is involved in the regulation of cortisol activity in the testis and thus in the regulation of spermatogenesis

  4. Effects of age, weaning and/or social isolation on the expression of genes regulating HSD11B2.

  5. The expression of 11beta-HSD2 in several types of cells forms consecutive lines of defense may protect spermatogonia against glucocorticoid-induced apoptosis.

  6. 11beta-HSD (show HAL Proteins) type 2, which is abundantly expressed, plays important roles in cortisol inactivation in pig Leydig cells.

  7. The amount of 11beta-HSD 2 in germ cells was greatest at birth, decreased thereafter and was absent after Week 3.

Cow (Bovine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. investigation of expression for 11HSD1, 11HSD2, and glucocorticoid receptor (show NR3C1 Proteins) during follicular maturation and atresia: in atretic follicles, expression of 11HSD2 increased in both granulosa cells and theca interna layers

Mouse (Murine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. Kidney-specific deficiency of 11beta-HSD2 leads to Salt-dependent Hypertension, which is attributed to mineralocorticoid receptor (show NR3C2 Proteins)-epithelial sodium channel-Na(+)-Cl(-) cotransporter (show SLC12A3 Proteins) activation in the kidney.

  2. Rac1 GTPase (show RACGAP1 Proteins) regulates 11beta-HSD2 expression, mineralocorticoid receptor (show NR3C2 Proteins) activation, and mineralocorticoid receptor (show NR3C2 Proteins)-mediated pro-fibrotic signaling.

  3. Nr3c2 (show NR3C2 Proteins) has a role in mouse skin development in a process that involves HSD11B1 (show HSD11B1 Proteins)/HSD11B2

  4. Reduced brain 11betaHSD2 promotes a hunger for salt and salt sensitivity. 11betaHSD2-positive neurons integrate salt appetite and the blood pressure response to dietary sodium through a mineralocorticoid receptor (show NR3C2 Proteins)-dependent pathway.

  5. 11betaHSD2 inhibition suppressed lung tumor growth and invasion in association with increased tissue active glucocorticoid levels, decreased COX-2 expression, inhibition of ERK (show EPHB2 Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.

  6. results show that intestinal epithelial 11ssHSD2 activity contributes to increased COX-2 expression in Apc (show APC Proteins)+/min intestinal adenomas and that 11ssHSD2 deficiency in intestinal epithelial cells suppresses adenoma development and growth

  7. 11beta-hydroxysteroid dehydrogenase-2 is a cortisol-inactivating enzyme with a role in keratinocyte cell proliferation and basal cell proliferation

  8. Reduced 11beta-hydroxysteroid dehydrogenase type 2 causes salt sensitivity of blood pressure because of impaired renal natriuretic capacity.

  9. findings implicate DNA methylation (show HELLS Proteins) as a mechanism by which prenatal stress alters HSD11B2 gene expression

  10. This study found that 11beta-hydroxysteroid dehydrogenase type 2 knockout mice develop nephrogenic diabetes insipidus.

Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Protein Profile

Protein Summary

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

Alternative names and synonyms associated with Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)

  • hydroxysteroid (11-beta) dehydrogenase 2 (hsd11b2)
  • hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2)
  • hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2)
  • NAD-dependent 11-beta-hydroxysteroid dehydrogenase (HSD11K)
  • 11-HSD2 protein
  • 11HSD2 protein
  • AME protein
  • AME1 protein
  • HSD2 protein
  • HSD11B2 protein
  • HSD11K protein
  • MGC81883 protein
  • SDR9C3 protein

Protein level used designations for HSD11B2

hydroxysteroid (11-beta) dehydrogenase 2 , corticosteroid 11-beta-dehydrogenase isozyme 2 , 11 beta-hydroxysteroid dehydrogenase type 2 , -HSD11 type II , 11-DH2 , 11-beta-HSD2 , 11-beta-hydroxysteroid dehydrogenase type 2 , 11-beta-hydroxysteroid dehydrogenase type II , NAD-dependent 11-beta-hydroxysteroid dehydrogenase , short chain dehydrogenase/reductase family 9C member 3 , 11-beta hydroxysteroid dehydrogenase , hydroxysteroid 11-beta dehydrogenase 2 , 11-beta-hydroxysteroid dehydrogenase 2 , 11(beta)-HSD2 , Hydroxysteroid dehydrogenase, 11 beta type 2

444491 Xenopus laevis
100034124 Equus caballus
100529249 Felis catus
3291 Homo sapiens
396948 Sus scrofa
282434 Bos taurus
100009531 Oryctolagus cuniculus
489758 Canis lupus familiaris
15484 Mus musculus
25117 Rattus norvegicus
443530 Ovis aries
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