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Human L1CAM Protein expressed in Human Cells - ABIN2002161
Rosenthal, Jouet, Kenwrick: Aberrant splicing of neural cell adhesion molecule L1 mRNA in a family with X-linked hydrocephalus. in Nature genetics 1993
Show all 6 Pubmed References
L1CAM failed to be a clinically relevant marker of poor prognosis in stage I endometrioid endometrial carcinoma
This study revealed an unexpected role of L1CAM in the pathological crosstalk between the immune and nervous systems.
Mutations involving L1 cell adhesion molecule is associated with chemotherapy-resistant urothelial carcinoma.
Data suggest that targeted therapy to neural cell adhesion molecule L1 (L1) might be effective in the treatment of retinoblastoma tumors.
CD10 (show MME Proteins) is a necessary component conferring the L1 effects in CRC (show CALR Proteins) cells. The identification of gene expression patterns of L1-domain-specific point mutations may provide novel markers and targets for interfering with L1-mediated CRC (show CALR Proteins) progression.
High L1-CAM (show CALM1 Proteins) expression is associated with low radiosensitivity in neuroblastoma (show ARHGEF16 Proteins).
Neural cell adhesion molecule L1 (L1CAM)-mediated cell-cell aggregation was severely impaired by L1CAM variants p.I37N, p.M172I and p.D202Y but was preserved by the variant p.T38M.
The differential expression timing of CD184 (show CXCR4 Proteins) and CD171 permits identification and enrichment of RGCs from retinal organoids at differing maturation states from committed progenitors to differentiating neurons.
This study examined the spatiotemporal distribution of L1CAM in the early human fetal period by means of immunohistochemistry and in situ hybridization. In advanced differentiated epithelia such as those of the gastrointestinal system, L1CAM localization vanishes. In epithelia, however, which undergo further development such as those of the urogenital system, L1CAM is further needed for their fully establishment.
The expression of L1CAM was associated with advanced stage, nodal involvement, high tumour grade, non-endometrioid histology, lymphovascular space invasion, and distant recurrences in all cases, and with reduced survival in the endometrial carcinomas, but not in the non-endometrioid carcinomas. L1CAM may induce EMT (show ITK Proteins)-like changes, but seems to only play a role in metastasis, not in invasion.
induced expression of L1CAM or PSA (show NPEPPS Proteins)-NCAM (show NCAM1 Proteins) in the iPSC-derived DA neurons cannot completely restore the neurite outgrowth potential that was reduced in these DA neurons as a consequence of epigenetic aberrations resulting from the iPSC reprogramming process.
Heterozygous L1CAM-deficient mice express an autism-like phenotype.
tumors in stressed animals demonstrated markedly enhanced expression of VEGFR-2 (show KDR Proteins) and L1CAM mRNA as well as pERK (show EIF2AK3 Proteins), MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins) protein expression.
Function-triggering antibodies to the adhesion molecule (show NCAM1 Proteins) L1 enhance recovery after injury of the adult mouse femoral nerve.
We suggest that L1 stimulates neuritogenesis by activating CK2alpha leading to decreased levels of PTEN and p53 (show TP53 Proteins) via a novel, L1-triggered and CK2alpha-mediated signal transduction pathway.
a positive relationship between L1 and pPKD1 in both cultured cerebellar neurons and human cerebellar tissue, suggesting that L1 functions in the modulation of PKD1 (show PKD1 Proteins) phosphorylation.
Myelin basic protein (show MBP Proteins) cleaves cell adhesion molecule (show MCAM Proteins) L1 and promotes neuritogenesis and cell survival.
These results demonstrate that L1 promotes neuronal differentiation from ESCs (show NR2E3 Proteins) through the L1-mediated enhancement of FUT9 (show FUT9 Proteins) and ST3Gal4 (show ST3GAL4 Proteins) expression.
L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment which is cleaved by cathepsin E (show CTSE Proteins)
the neurite outgrowth promoted by Neural Cell Adhesion Molecule L1 was strongly inhibited by siRNA against FGF21 (show FGF21 Proteins) gene or a treatment of cells with FGFR (show FGFR2 Proteins) inhibitor
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
neural cell adhesion molecule L1
, antigen identified by monoclonal antibody R1
, N-CAM L1
, nerve-growth factor-inducible large external glycoprotein
, neuron-glia cell adhesion molecule (Ng-CAM)
, neuronal-glial cell adhesion molecule