Browse our SNCA Proteins (SNCA)

Full name:
Synuclein, alpha Proteins (SNCA)
On are 72 Synuclein, alpha (SNCA) Proteins from 16 different suppliers available. Additionally we are shipping SNCA Antibodies (659) and SNCA Kits (68) and many more products for this protein. A total of 824 SNCA products are currently listed.
alphaSYN, LOC619283, MGC64356, NACP, PARK1, PARK4, PD1, snca
list all proteins Gene Name GeneID UniProt
SNCA 20617 O55042
SNCA 6622 P37840
SNCA 29219 P37377

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SNCA Proteins (SNCA) by Origin

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Top referenced SNCA Proteins

  1. Mouse (Murine) SNCA Protein expressed in Escherichia coli (E. coli) - ABIN667142 : Kim: Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil. in Molecules and cells 1997 (PubMed)
    Show all 3 references for 667142

  2. Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN1046507 : Uéda, Fukushima, Masliah, Xia, Iwai, Yoshimoto, Otero, Kondo, Ihara, Saitoh: Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 3 references for 1046507

  3. Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN2005039 : Lee, Choi, Lee: Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for 2005039

  4. Rat (Rattus) SNCA Protein expressed in Rabbit - ABIN1742284 : Jüttner, Moré, Das, Babich, Meier, Henning, Erdmann, Mu Ller, Otto, Grantyn, Rathjen: Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. in Neuron 2005 (PubMed)

More Proteins for SNCA Interaction Partners

Xenopus laevis Synuclein, alpha (SNCA) interaction partners

  1. study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg (show SNCG Proteins)) during embryogenesis

Mouse (Murine) Synuclein, alpha (SNCA) interaction partners

  1. Data suggest that endocytosis is the principal mechanism by which proteopathic alpha-synuclein aggregates are internalized in primary hippocampal neurons in culture; aggregates are rapidly trafficked along endosomal/lysosomal pathway, where most of the material remains for days as proposed in neurodegenerative synucleinopathies.

  2. LRRK2 (show LRRK2 Proteins) negatively regulates the clearance of alphaSYN accompanied by down-regulation of the endocytosis pathway; LRRK2 (show LRRK2 Proteins) in microglia may function as the offending molecule responsible for neurodegeneration, in terms of down-regulation of alphaSYN clearance.

  3. sideroflexin 3 (SFXN3 (show SFXN3 Proteins)) was found to be a mitochondrial protein (show COX6B2 Proteins) localized to the inner mitochondrial membrane.

  4. The ability of monomeric alpha-synuclein to enhance ATP synthase efficiency under physiological conditions may be of importance when alpha-synuclein undergoes the misfolding and aggregation

  5. Rab7 (show RAB7A Proteins) accumulated in GCase (show GBA Proteins) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (show GBA Proteins) can reverse ALR (show GFER Proteins) impairment, we anticipate that strategies to restore GCase (show GBA Proteins) activity in the brains of both sporadic patients with PD and those with GBA1 (show GBA Proteins) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.

  6. Study showed that apoptosis is an important form of cellular degeneration in lipopolysaccharide (LPS (show TLR4 Proteins)-sensitized hypoxic-ischemic (HI) injury in the immature brain. Loss of PINK1 (show PINK1 Proteins) can protect the immature brain against cell apoptosis induced by LPS (show TLR4 Proteins)-sensitized HI injury. Moreover, alpha-Syn plays a neuroprotective role in LPS (show TLR4 Proteins)-sensitized HI brain damage in PINK1 (show PINK1 Proteins)-knockout neonatal mice

  7. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  8. These results indicate that fragmented amyloid-like aggregates of short alpha-syn fibrils are the key pathogenic seeds that trigger prion (show PRNP Proteins)-like conversion.

  9. In summary, we have combined multiple data sets to identify transcripts, which are strong candidates for being phenotypic modifiers, and demonstrated SNCA is a modifier of pathology in motor neuron disease.

  10. In alpha-synuclein knock-out mice there was a decrease in neuronal glucose metabolism in cerebral cortex gray matter.

Human Synuclein, alpha (SNCA) interaction partners

  1. Data suggest that endocytosis is the principal mechanism by which proteopathic alpha-synuclein aggregates are internalized in primary hippocampal neurons in culture; aggregates are rapidly trafficked along endosomal/lysosomal pathway, where most of the material remains for days as proposed in neurodegenerative synucleinopathies.

  2. Data suggest that endocytosis and lysosomal processing of proteopathic alpha-synuclein aggregates in neurons are consistent with models of neurodegeneration in synucleinopathies. [EDITORIAL]

  3. These results indicate that LRRK2 (show LRRK2 Proteins) and alpha-synuclein participate in the dysregulation of CADPS2 (show CADPS2 Proteins) by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.

  4. Increasing evidence supports that small alpha-synuclein aggregates or oligomers may be the real culprit, causing deficits in neurotransmission and neurogenesis in the hippocampus and related brain regions, which constitute the major mechanism for the hippocampal dysfunctions and associated neuropsychiatric manifestations in synucleinopathies. [alpha-synuclein]

  5. Most anti-PD1 (show PDCD1 Proteins)-related adrenal insufficiency cases involved an isolated ACTH (show POMC Proteins) deficiency. Eosinophilia may be an early indicator before the onset of symptoms.

  6. Significantly higher transcript expression levels of PD1 (show PDCD1 Proteins) were found in tumor tissue, whilst a general increase in PDL1 (show CD274 Proteins) expression was found in tumor tissues, although this did not reach statistical significance. Our study demonstrates higher levels of expression of PDL1 (show CD274 Proteins) are associated with favorable clinical outcome.

  7. The chemical properties of cell membrane lipids determine whether or not the lipids can trigger the aggregation of alpha-synuclein.

  8. The absence of mutations in SNCA genes reveals that they are uncommon causes of Parkinson disease in Brazil

  9. AEP is activated and cleaves human alpha-synuclein at N103 in an age-dependent manner.

  10. Alpha-synuclein fibrils elicit protein accumulation and aggregation in dopamine neurons. Synaptic pathology is linked to alpha-synuclein aggregation. Alpha-synuclein fibrils compromise dopamine neuron survival in a dose- and time-dependent manner.

Cow (Bovine) Synuclein, alpha (SNCA) interaction partners

  1. analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 Proteins) [ANXB12]

  2. Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.

SNCA Protein Profile

Protein Summary

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Alternative names and synonyms associated with SNCA

  • synuclein, alpha (snca)
  • alpha-synuclein (LOC619283)
  • alpha-synuclein (LOC100359228)
  • synuclein, alpha (Snca)
  • synuclein, alpha (non A4 component of amyloid precursor) (SNCA)
  • synuclein, alpha (non A4 component of amyloid precursor) (Snca)
  • alphaSYN protein
  • LOC619283 protein
  • MGC64356 protein
  • NACP protein
  • PARK1 protein
  • PARK4 protein
  • PD1 protein
  • snca protein

Protein level used designations for Synuclein, alpha Proteins (SNCA)

synuclein, alpha , alpha-synuclein , alpha SYN , non-A beta component of AD amyloid , non-A4 component of amyloid , non A-beta component of AD amyloid , synuclein alpha-140 , alpha synuclein

380315 Xenopus laevis
619283 Takifugu rubripes
100359228 Oryctolagus cuniculus
20617 Mus musculus
6622 Homo sapiens
29219 Rattus norvegicus
641350 Sus scrofa
282857 Bos taurus
395393 Gallus gallus
100294604 Ovis aries
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