SNCA Protein (full length)
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- Target See all SNCA Proteins
- SNCA (Synuclein, alpha (SNCA))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- full length
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)
- Sequence
- MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA
- Specificity
- ~14.46 kDa
- Purification
- Ion-exchange Purified
- Biological Activity Comment
- Endogenous alpha-synuclein phosphorylation. 100 μM alpha synuclein protein monomer (SPR-323) seeded with 10 nM alpha synuclein protein PFF (SPR-324) in 25 μM Thioflavin T (PBS pH 7.4, 100 μl reaction volume) generated an increased fluorescence intensity after incubation at 37°C with shaking at 600 rpm for 24 hours. Fluorescence was measured by excitation at 450 nm and emission at 485 nm on a Molecular Devices Gemini XPS microplate reader.
- Top Product
- Discover our top product SNCA Protein
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Synuclein, alpha (SNCA) (Ala53Thr-Mutant) (Active) protein
SNCA Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active
Synuclein, alpha (SNCA) (full length) (Active) proteinSNCA Origin: Human Host: Escherichia coli (E. coli) Recombinant >95% pure using SDS-PAGE analysis. SDS, WB, in vitro, in vivo Active
Synuclein, alpha (SNCA) proteinSNCA Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Synuclein, alpha (SNCA) (AA 1-140) protein (His tag)SNCA Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Synuclein, alpha (SNCA) (AA 1-140) protein (GST tag)SNCA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Synuclein, alpha (SNCA) (AA 31-140) protein (GST tag)SNCA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Synuclein, alpha (SNCA) protein (His tag)SNCA Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Synuclein, alpha (SNCA) (AA 1-139), (partial) protein (GST tag)SNCA Origin: Human Host: Escherichia coli (E. coli) Recombinant 90 % SDS, ELISA
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Certified >95% pure using SDS-PAGE analysis.
- Restrictions
- For Research Use only
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- Concentration
- Lot specific
- Buffer
- PBS pH 7.4
- Storage
- -80 °C
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- Target
- SNCA (Synuclein, alpha (SNCA))
- Alternative Name
- Alpha Synuclein (SNCA Products)
- Synonyms
- snca Protein, MGC64356 Protein, LOC619283 Protein, NACP Protein, alphaSYN Protein, PARK1 Protein, PARK4 Protein, PD1 Protein, synuclein alpha L homeolog Protein, alpha-synuclein Protein, synuclein alpha Protein, synuclein, alpha Protein, snca.L Protein, LOC619283 Protein, SNCA Protein, Snca Protein
- Background
- Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
- Gene ID
- 20617
- NCBI Accession
- NP_001035916
- UniProt
- O55042
- Pathways
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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