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orchestrated regulation of MHC II surface expression in thymic epithelial cells (TECs) by MARCH 8 and CD83 plays a major role in CD4 (show CD4 Proteins)(+) T cell selection.
CD83-mediated MHCII stabilization through antagonism of March8 as a novel functional adaptation of cortical epithelial cells for T cell selection.
results show that CD83 is important for B cell activation and modulates germinal center composition and IgE Ab responses in vivo
Our findings indicate that CD83 homotypic interactions regulate DC activation and promote mucosal homeostasis.
CD83(+) T cells share important features with regulatory T cells, identifying CD83 as a novel lineage marker to discriminate between different T cell populations.
CD83 differentially modulates follicular and marginal zone B cell responses
Dendritic cells co-cultivated with antigen-specific induced Tregs expressed lower levels of CD83. A major suppressive mechanism of DC function by iTregs is secondary to the effects of IL-10 (show IL10 Proteins) on MARCH1 & CD83 expression.
activated T cells induce CD83 on B cells via CD40 engagement but independent of TCR/MHC binding and thus independent of antigen-specificity of B cells.
found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1
Data strongly suggest that CD83 is expressed by B cells upon activation and contributes to the regulation of B cell function.
the presence of CD83 in mDC (show ADAM11 Proteins) membranes enhances T lymphocyte proliferation by boosting calcium release from intracellular stores in these cells.
this study shows differential expression and function of CD83 on human immune cells, and reveals potential new roles for this molecule as a target of therapeutic manipulation in transplantation, inflammation, and autoimmune diseases
We conducted a genome-wide association study (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine ratio. A single SNP at 6p23 (near CD83) and several SNPs at 7p21 (near AHR (show AHR Proteins)), 15q24 (near CYP1A2 (show CYP1A2 Proteins)) and 19q13.2 (near CYP2A6 (show CYP2A6 Proteins)) met GW-significance (P < 5 x 10-8) and were associated with one or more metabolites
Crystal structure of human CD83 reveals that its surface domain consists of an Ig-like domain only.CD83 exerts its immunological activity by mixed homotypic and heterotypic interactions as typically observed for proteins present in the immunological synapse.
this study shows that dendritic cells from rheumatoid arthritis patients have low expression levels of CD83
Triple costimulation via CD80 (show CD80 Proteins), 4-1BB (show TNFRSF9 Proteins), and CD83 ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2 (show IL2 Proteins).
nonspreading Rift Valley fever virus infection of monocyte-derived immature denditic cells results in incomplete maturation, associated with gradual downregulation of CD83.
Sustained expression of CD83 was observed when CD4 (show CD4 Proteins)+ T cells were induced by transforming growth factor-beta to differentiate into CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+ forkhead box P3 (show FOXP3 Proteins)+ regulatory T (iTreg) cells.
These results suggest that HTLV-I induces CD83 expression on T cells via Tax1 (show CNTN2 Proteins) -mediated NF-kappaB (show NFKB1 Proteins) activation, which may promote HTLV-I infection in vivo.
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene.
, B-cell activation protein
, CD83 antigen
, CD83 antigen (activated B lymphocytes, immunoglobulin superfamily)
, cell surface protein HB15
, cell-surface glycoprotein