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The expression of ICOSL (show ICOSLG Proteins) in the cornea and the ICOS-mediated induction of Foxp3 (show FOXP3 Proteins)+ CD4 (show CD4 Proteins)+ regulatory T cells may contribute to successful corneal allograft survival.
this study reveals a previously unknown ICOS-TBK1 (show TBK1 Proteins) signaling pathway that specifies the commitment of germinal center follicular helper T cells
IFNAR1 (show IFNAR1 Proteins)-deficiency accelerated humoral immune responses and parasite control by boosting ICOS-signalling in two non-lethal murine models of malaria
Fecal levels of Crp1 (show CRIP1 Proteins) were significantly decreased in mice with graft-versus-host disease and were correlated with intestinal flora diversity.
IL-10 (show IL10 Proteins) production by CD4 (show CD4 Proteins)(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 (show IL27 Proteins) receptor signaling that is supported after CD4 (show CD4 Proteins)(+) T cell priming by ICOS signaling.
these data suggest ICOS is not required for follicular Th cell induction during Plasmodium chabaudi chabaudi AS infection
the ICOS signaling has a regulatory effect on CD154 (show CD40LG Proteins)/CD40 (show CD40 Proteins) expressions, and may play an important role in the hepatic egg granuloma formation of schistosomiasis.
data identify a role of ICOS in innate immunity and indicate that not only cytokines, but also costimulatory pathways such as those involving ICOS, can contribute to regulate the ILC2 pool.
results indicate that ILC2s might interact with B7RP-1 (show ICOSLG Proteins)-expressing DCs in allergic inflammatory lung, and ICOS signaling can positively regulate the protease allergen-induced ILC2 activation followed by eosinophil infiltration into the lungs
these data show a role for IL-6 (show IL6 Proteins) in promoting "effector" Tregs accrual with age likely through maintenance of ICOS expression.
This is the first replication association study of rs4325730 upstream of ICOS (show CTLA4 Proteins) with AIH in the Japanese population and rs4325730G is a risk allele.
the induction pathway of ICOS (show CTLA4 Proteins)(+) Foxp3 (show FOXP3 Proteins)(+) cells was analyzed
ratio of ICOS (show CTLA4 Proteins)(+) /PD-1 (show PDCD1 Proteins)(+) Tfh cells and the frequency of IL-21 (show IL17C Proteins)(+) Tfh cells may be indicators for evaluating the idiopathic membranous nephropathy development
The ICOS (show CTLA4 Proteins) and ICOSL (show ICOSLG Proteins) SNPs examined do not have an apparent effect on the disease susceptibility and prognosis of autoimmune thyroid diseases.
Follicular helper T cells differentiation is a multistage process involving BCL6 (show BCL6 Proteins) and other transcription factors, cytokines, and costimulation through ICOS (show CTLA4 Proteins) and several other molecules. (Review)
findings show Tregs from inflamed lung of sarcoidosis patients characterized by ICOS (show CTLA4 Proteins)(high) phenotype; high-level ICOS (show CTLA4 Proteins) expression was restricted to Tregs from inflamed lung and was absent in blood Tregs of sarcoidosis patients and in lung and blood Tregs of healthy volunteers; potential implication of ICOS/ICOS (show CTLA4 Proteins)-L (show ICOSLG Proteins) immune-regulatory axis in in disease activity and resolution
findings indicated that circulating memory Tfh cells, especially CCR7 (show CCR7 Proteins)+ICOS (show CTLA4 Proteins)+ memory Tfh cells, may be associated with the relapse of MS and may serve as a new therapeutic target
Expression of mutant caspase-9 (show CASP9 Proteins) correlated with a downregulation of BAFFR (show TNFRSF13C Proteins) (B-cell-activating factor (show TNFSF13B Proteins) belonging to the TNF (show TNF Proteins) family (BAFF) receptor (show TNFRSF13C Proteins)) in B cells and ICOS (inducible T-cell costimulator) in T cells.
Single nucleotide polymorphisms in RBPJ (show RBPJ Proteins), IL1R1 (show IL1RN Proteins), REV3L, TRAF3IP2 (show TRAF3IP2 Proteins), IRF1 (show IRF1 Proteins) and ICOS (show CTLA4 Proteins) showed association with rheumatoid arthritis in black South Africans.
This study found that ICOS rs1559931 SNP was associated with decreased hepatitis B virus-related hepatocellular carcinoma risk in the studied Chinese Han population, except for patients with natural clearance of hepatitis B virus.
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
inducible T-cell costimulator
, inducible T-cell co-stimulator
, CD28 and CTLA-4-like protein
, CD28-related protein 1
, activation-inducible lymphocyte immunomediatory molecule
, inducible costimulator