ICOS Protein (Fc Tag)
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- Target See all ICOS Proteins
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
- Protein Type
- Recombinant
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Origin
- Rat
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ICOS protein is labelled with Fc Tag.
- Purpose
- Recombinant Rat ICOS/AILIM/CD278 Protein (Fc Tag)
- Sequence
- Met1-Leu142
- Characteristics
- A DNA sequence encoding the rat ICOS (Q9R1T7-1) (Met1-Leu142) was expressed with the Fc region of human IgG1 at the C-terminus.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product ICOS Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
- Alternative Name
- ICOS/AILIM/CD278 (ICOS Products)
- Synonyms
- ICOS Protein, AILIM Protein, CCLP Protein, CRP-1 Protein, H4 Protein, Ly115 Protein, CD278 Protein, CVID1 Protein, Ailim Protein, inducible T-cell costimulator Protein, inducible T cell co-stimulator Protein, inducible T-cell co-stimulator Protein, ICOS Protein, LOC100232284 Protein, Icos Protein
- Background
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Background: Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.Immune CheckpointImmune Checkpoint ProteinsImmune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: ICOS;Ailim
- Molecular Weight
- 40.7 kDa
- Pathways
- Cancer Immune Checkpoints
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