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Browse our anti-ITK (ITK) Antibodies

Full name:
anti-IL2-Inducible T-Cell Kinase Antibodies (ITK)
On are 111 IL2-Inducible T-Cell Kinase (ITK) Antibodies from 21 different suppliers available. Additionally we are shipping ITK Proteins (10) and ITK Kits (5) and many more products for this protein. A total of 138 ITK products are currently listed.
EMT, LPFS1, LYK, PSCTK2, Tcsk, Tsk
list all antibodies Gene Name GeneID UniProt
ITK 16428 Q03526
ITK 3702 Q08881
ITK 363577  

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Most Popular Reactivities for anti-ITK (ITK) Antibodies

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anti-Mouse (Murine) ITK Antibodies:

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anti-Rat (Rattus) ITK Antibodies:

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Top referenced anti-ITK Antibodies

  1. Human Polyclonal ITK Primary Antibody for EIA, WB - ABIN359985 : Brazin, Mallis, Fulton, Andreotti: Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 5 references for ABIN359985

  2. Human Monoclonal ITK Primary Antibody for WB - ABIN2869313 : Perez-Villar, ODay, Hewgill, Nadler, Kanner: Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha). in International immunology 2001 (PubMed)
    Show all 3 references for ABIN2869313

  3. Human Monoclonal ITK Primary Antibody for IP, WB - ABIN967287 : Heyeck, Wilcox, Bunnell, Berg: Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. in The Journal of biological chemistry 1997 (PubMed)
    Show all 3 references for ABIN967287

  4. Human Monoclonal ITK Primary Antibody for ICC, FACS - ABIN969222 : Huck, Feyen, Niehues, Rüschendorf, Hübner, Laws, Telieps, Knapp, Wacker, Meindl, Jumaa, Borkhardt: Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. in The Journal of clinical investigation 2009 (PubMed)
    Show all 2 references for ABIN969222

  5. Human Monoclonal ITK Primary Antibody for ELISA, WB - ABIN1724708 : Graves, Siroux, Guerra, Klimecki, Martinez: Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. in The Journal of allergy and clinical immunology 2005 (PubMed)
    Show all 2 references for ABIN1724708

  6. Human Polyclonal ITK Primary Antibody for WB - ABIN374095 : Tanaka, Asao, Ohtani, Nakamura, Sugamura: A novel human tyrosine kinase gene inducible in T cells by interleukin 2. in FEBS letters 1993 (PubMed)

More Antibodies against ITK Interaction Partners

Mouse (Murine) IL2-Inducible T-Cell Kinase (ITK) interaction partners

  1. pharmacological inhibition of ITK resulted in T cell hyperplasia and the increased production of TH2-type cytokines.

  2. ITK and BTK (show BTK Antibodies) regulate thermal homeostasis during septic response through mast cell function in mice.

  3. Taken together, these data indicate that ITK plus RLK (show TXK Antibodies) inhibition may have therapeutic potential in Th1 (show HAND1 Antibodies)-mediated inflammatory diseases.

  4. This work has important implications for understanding the role of Itk signaling in the development versus function of iNKT cells, Th1 (show HAND1 Antibodies), Th2, and Th17 cells.

  5. The kinase Itk and the adaptor TSAd (show SH2D2A Antibodies) change the specificity of the kinase Lck (show LCK Antibodies) in T cells by promoting the phosphorylation of Tyr192.

  6. Data indicate that the interleukin-2 (show IL2 Antibodies) inducible tyrosine kinase (show TYRO3 Antibodies) K390R point mutation (Itk-KD) transgenic mice were largely protected from inflammatory symptoms in an Ovalbumin (show OVA Antibodies) model of airway inflammation.

  7. The Itk pleckstrin (show PLEK Antibodies) homology domain binds to Calmodulin (show Calm2 Antibodies) and PI(3,4,5)Pto promote efficient calcium signaling and IL-17A (show IL17A Antibodies) production.

  8. Signaling by Itk promotes autoimmunity and CNS inflammation.

  9. ITK thus regulates the development and function of Tregs.

  10. Data indicate that the IL2-inducible T-cell kinase itk(-/-) innate zinc finger protein 145 PLZF (show ZBTB16 Antibodies)(+)CD4 (show CD4 Antibodies)(+) T cells express alphabeta TCRs, neither beta2-microglobulin-dependent MHC class I nor any MHC class II molecules are required for their development.

Human IL2-Inducible T-Cell Kinase (ITK) interaction partners

  1. We conclude that ITK, formerly considered an immune cell-specific protein, is aberrantly expressed in melanoma and promotes tumor development and progression

  2. The kinase Itk and the adaptor TSAd (show SH2D2A Antibodies) change the specificity of the kinase Lck (show LCK Antibodies) in T cells by promoting the phosphorylation of Tyr192.

  3. Found that 38% and 14% of the Angioimmunoblastic T-cell lymphoma cases exhibited gains of ITK and SYK (show SYK Antibodies) genes, respectively.

  4. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK (show TXK Antibodies), and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.

  5. approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR (show EGFR Antibodies) in EGFR (show EGFR Antibodies)-dependent PC9 (show PCSK9 Antibodies) cells, and these genes include seven of nine Src (show SRC Antibodies) family kinase genes, FGFR1 (show FGFR1 Antibodies), FGFR2 (show FGFR2 Antibodies), ITK, NTRK1 (show NTRK1 Antibodies), NTRK2 (show NTRK2 Antibodies), MOS (show MOS Antibodies), MST1R (show MST1R Antibodies), and RAF1 (show RAF1 Antibodies).

  6. ITK deficiency is a genetic cause of idiopathic CD4 (show CD4 Antibodies)+ T-cell lymphopenia.

  7. Data indicate reduced T-cell activation by altered IL-2 inducible T-cell kinase (ITK) expression in vitro.

  8. T-cell-specific human ITK-Syk (show SYK Antibodies) oncogene (show RAB1A Antibodies) in mice leads to early polyclonal T cell lymphoproliferation (show FAS Antibodies) with B cell expansion. It induces terminal T cell differentiation via Blimp-1 (show PRDM1 Antibodies), eliminating oncogene (show RAB1A Antibodies)-expressing cells early in development.

  9. Case Report/Letter: ITK/SYK (show SYK Antibodies) translocation in angioimmunoblastic T-cell lymphoma.

  10. a new pathway regulated by Itk in cells, and suggest cross talk between Itk and G-protein signaling downstream of the TcR.

ITK Antigen Profile

Antigen Summary

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.

Alternative names and synonyms associated with ITK

  • IL2 inducible T cell kinase (Itk) antibody
  • IL2-inducible T-cell kinase (ITK) antibody
  • IL2-inducible T-cell kinase (Itk) antibody
  • EMT antibody
  • LPFS1 antibody
  • LYK antibody
  • PSCTK2 antibody
  • Tcsk antibody
  • Tsk antibody

Protein level used designations for ITK

T-cell-specific kinase , interleukin-2-inducible T cell kinase , kinase TLK , tyrosine-protein kinase ITK/TSK , IL-2-inducible T cell kinase , IL-2-inducible T-cell kinase , homolog of mouse T-cell itk/tsk , interleukin-2-inducible T-cell kinase , kinase EMT , tyrosine-protein kinase LYK

16428 Mus musculus
3702 Homo sapiens
363577 Rattus norvegicus
489159 Canis lupus familiaris
100523474 Sus scrofa
522311 Bos taurus
416247 Gallus gallus
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