Browse our anti-GRP78 (HSPA5) Antibodies

Full name:
anti-Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) Antibodies (HSPA5)
On www.antibodies-online.com are 513 Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) Antibodies from 32 different suppliers available. Additionally we are shipping GRP78 Kits (41) and GRP78 Proteins (25) and many more products for this protein. A total of 590 GRP78 products are currently listed.
Synonyms:
AL022860, AU019543, baffled, Bip, cb865, D2Wsu17e, D2Wsu141e, fb60h09, fi36d04, GRP-78, Grp78, Hsce70, hspa5a, mBiP, MIF2, SEZ-7, Sez7, wu:fb60h09, wu:fi36d04, zgc:55994, zgc:77606
list all antibodies Gene Name GeneID UniProt
HSPA5 3309 P11021
HSPA5 14828 P20029
HSPA5 25617 P06761

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Most Popular Reactivities for anti-GRP78 (HSPA5) Antibodies

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anti-Human GRP78 Antibodies:

anti-Mouse (Murine) GRP78 Antibodies:

anti-Rat (Rattus) GRP78 Antibodies:

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Top referenced anti-GRP78 Antibodies

  1. Chicken Polyclonal GRP78 Primary Antibody for FACS, ICC - ABIN446401 : Pepping, Freeman, Gupta, Keller, Bruce-Keller: NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. in American journal of physiology. Endocrinology and metabolism 2013 (PubMed)
    Show all 13 references for 446401

  2. Dog (Canine) Polyclonal GRP78 Primary Antibody for ICC, IF - ABIN863190 : Cho, Park, Kim, Kim, Kim, Jang: BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1. in Molecular and cellular biology 2006 (PubMed)
    Show all 9 references for 863190

  3. Cow (Bovine) Monoclonal GRP78 Primary Antibody for ICC, IF - ABIN863112 : Yang, Turner, Gaut: The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. in The Journal of biological chemistry 1998 (PubMed)
    Show all 6 references for 863112

  4. Cow (Bovine) Monoclonal GRP78 Primary Antibody for ELISA, ICC - ABIN863113 : Koomägi, Mattern, Volm: Glucose-related protein (GRP78) and its relationship to the drug-resistance proteins P170, GST-pi, LRP56 and angiogenesis in non-small cell lung carcinomas. in Anticancer research 2000 (PubMed)
    Show all 6 references for 863113

  5. Human Polyclonal GRP78 Primary Antibody for EIA, IHC (p) - ABIN356850 : Sargent, Dunham, Trowsdale, Campbell: Human major histocompatibility complex contains genes for the major heat shock protein HSP70. in Proceedings of the National Academy of Sciences of the United States of America 1989 (PubMed)
    Show all 5 references for 356850

  6. Human Polyclonal GRP78 Primary Antibody for ICC, IF - ABIN152679 : Shin, Feltri, Wrabetz: Altered Trafficking and Processing of GALC Mutants Correlates with Globoid Cell Leukodystrophy Severity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 (PubMed)
    Show all 4 references for 152679

  7. Mouse (Murine) Monoclonal GRP78 Primary Antibody for Func, EIA - ABIN371046 : Bole, Hendershot, Kearney: Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas. in The Journal of cell biology 1986 (PubMed)
    Show all 3 references for 371046

  8. Human Polyclonal GRP78 Primary Antibody for IF, IHC (p) - ABIN651232 : Zhao, Zhang, Tian, Fang, Lu, Yuan, Yang, Wen: Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis. in Journal of medical virology 2009 (PubMed)
    Show all 2 references for 651232

  9. Human Polyclonal GRP78 Primary Antibody for FACS, IHC (p) - ABIN651231 : Zhuang, Scolyer, Murali, McCarthy, Zhang, Thompson, Hersey: Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010 (PubMed)
    Show all 2 references for 651231

More Antibodies against GRP78 Interaction Partners

Xenopus laevis Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. In amphibians, the association of BiP with unfolded protein and its possible role in aggresome function may be vital in the maintenance of cellular proteostasis.

  2. Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.

Human Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Results show that GRP78 was up-regulated in human prostate cancer and inversely correlated with PCA3 expression.

  2. Inhibition of 17beta-HSD (show HSD17B3 Antibodies) 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.

  3. GALNT6 (show GALNT6 Antibodies)-induced O-glycosylation is critical for the stability, subcellular localization, and anti-apoptotic function of GRP78 protein in cancer cells. We also suggest that GRP78 might enhance the activity of GALNT6 (show GALNT6 Antibodies) in carcinogenesis through driving Golgi-to-ER relocation of GALNT6 (show GALNT6 Antibodies).

  4. BiP (show GDF10 Antibodies) binds to the unfolded state of MJ0366 and prevents its refolding, and that this effect is dependent on both the type and concentration of nucleotides.

  5. GRP78 control of fatty acid oxidation may represent a new homeostatic function for GRP78.

  6. in vitro and in vivo upregulation of Par-4 (show PAWR Antibodies) expression is indispensable for the trafficking of GRP78 to the cell membrane and subsequent apoptosis of cancer cell

  7. We found that 25-epi (show TFPI Antibodies) Ritterostatin GN1N induced cell death in melanoma cells at nanomolar concentrations, and this cell death was characterized by inhibition of GRP78 expression, increased expression of the ER stress marker CHOP (show DDIT3 Antibodies), loss of mitochondrial membrane potential, and lipidation of the autophagy marker protein LC3B (show MAP1LC3B Antibodies).

  8. Data suggest that, in breast cancer cells, expression of HSD17B5 (show AKR1C3 Antibodies) and expression of GRP78 (an apoptosis inhibitor) are strongly but negatively correlated; GRP78 knockdown decreases breast cancer cell viability whereas HSD17B5 (show AKR1C3 Antibodies) knockdown increases cell viability and cell proliferation. (HSD17B5 (show AKR1C3 Antibodies), 17-beta-hydroxysteroid dehydrogenase 5; GRP78, 78 kDa glucose-regulated protein)

  9. Western blot analysis of subcutaneously implanted AsPC-1 and BxPC-3 tumors as well as orthotopically implanted Panc-1 tumors demonstrated upregulation of BIP (show GDF10 Antibodies), CHOP (show DDIT3 Antibodies), and IRE1alpha (show ERN1 Antibodies) expression in the tumor lysates from penfluridol-treated mice as compared to tumors from control mice

  10. HSP78 (show CLPB Antibodies) on the cell surface was upregulated in human neuroblastoma (show ARHGEF16 Antibodies) cells (SK-N-SH) infected with Enterovirus 71

Cow (Bovine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. This paper reports the localization of both GRP78 and HSP60 (show HSPD1 Antibodies) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (show HSPD1 Antibodies) in the sperm midpiece.

  2. BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death

Pig (Porcine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Over-expression of GRP78 enhances replication of Porcine Circovirus 2.

Mouse (Murine) Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Upregulating HSF1 (show HSF1 Antibodies) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP (show DDIT3 Antibodies) and increasing HSP70 (show HSP70 Antibodies) a5 (BiP/GRP78). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (show HSF1 Antibodies) being one likely key player in both systems.

  2. These results demonstrate a key role for GRP78 in alveolar epithelial cell survival.

  3. These results indicate that GRP78, an endoplasmic reticulum chaperon of the HSP70 (show HSP70 Antibodies) family, is a novel host factor involved at multiple steps of the Japanese encephalitis virus life cycle and could be a potential therapeutic target.

  4. Genetic or pharmacologic inhibition of the HSPA5-GPX4 (show GPX4 Antibodies) pathway enhanced gemcitabine sensitivity by disinhibiting ferroptosis in vitro and in both subcutaneous and orthotopic animal models of PDAC.

  5. The data presented indicate that the unfolded protein response is activated in fibrotic lung tissue and strongly localized to macrophages. GRP78- and CHOP (show DDIT3 Antibodies)-mediated macrophage apoptosis was found to protect against bleomycin-induced fibrosis.

  6. Endoplasmic reticulum stress gene GRP78 is involved in signaling pathway during hepatitis B virus-mediated hepatocarcinogenesis.

  7. data show that Med inhibits ER stress-induced apoptosis and promotes osteoblast cell survival by targeting GRP78.

  8. These results suggested the important roles of endoplasmic reticulum-related chaperons, Bip and SIL1 (show SIL1 Antibodies), in Alzheimer's disease-like tau hyperphosphorylation.

  9. We show that chronic VPA treatment did not modify the ATXN3 (show ATXN3 Antibodies) inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects

  10. these findings reveal a novel critical role of GRP78 in regulating ER stress-mediated apoptosis in cartilage development and the molecular mechanisms involved.

Zebrafish Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) interaction partners

  1. Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.

GRP78 (HSPA5) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.

Alternative names and synonyms associated with GRP78 (HSPA5)

  • 78 kDa glucose-regulated protein (CpipJ_CPIJ003550) antibody
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5) antibody
  • 78 kDa glucose-regulated protein (grp78) antibody
  • BiP/GRP78 (LOC100533358) antibody
  • glucose-regulated protein 78 (BiP/grp78) antibody
  • glucose-regulated protein 78 (Tc00.1047053506585.40) antibody
  • glucose-regulated protein 78 (Tb11.02.5450) antibody
  • glucose-regulated protein 78 (Tb11.02.5500) antibody
  • glucose-regulated protein 78 (LmjF28.1200) antibody
  • Hsp70 family ATPase KAR2 (KAR2) antibody
  • glucose-regulated protein 78kDa (grp78) antibody
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (hspa5) antibody
  • heat shock 70 kDa protein 5a (hspa5) antibody
  • heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (Hspa5) antibody
  • heat shock protein 5 (Hspa5) antibody
  • heat shock protein 5 (hspa5) antibody
  • AL022860 antibody
  • AU019543 antibody
  • baffled antibody
  • Bip antibody
  • cb865 antibody
  • D2Wsu17e antibody
  • D2Wsu141e antibody
  • fb60h09 antibody
  • fi36d04 antibody
  • GRP-78 antibody
  • Grp78 antibody
  • Hsce70 antibody
  • hspa5a antibody
  • mBiP antibody
  • MIF2 antibody
  • SEZ-7 antibody
  • Sez7 antibody
  • wu:fb60h09 antibody
  • wu:fi36d04 antibody
  • zgc:55994 antibody
  • zgc:77606 antibody

Protein level used designations for HSPA5

78 kDa glucose-regulated protein , GRP-78 , heat shock 70 kDa protein 5 , Protein 1603 , 78 kDa glucose-regulated protein homolog , luminal-binding protein , glucose-regulated protein 78 , glucose-regulated protein 78kDa , heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) , GRP 78 , biP , heavy-chain binding protein BiP , immunoglobulin heavy chain-binding protein , endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 , glucose-regulated protein, 78kDa , XAP-1 antigen , glucose regulated protein, 78 kDa , heat shock 70kD protein 5 (glucose-regulated protein, 78kD) , heat shock 70kD protein 5 , heat shock 70kDa protein 5 (glucose-regulated protein) , steroidogenesis-activator polypeptide , bip

GENE ID SPECIES
6034961 Culex quinquefasciatus
100173944 Pongo abelii
100196613 Salmo salar
100533358 Aplysia californica
543957 Solanum lycopersicum
3540481 Trypanosoma cruzi strain CL Brener
3665880 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3665885 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5653331 Leishmania major strain Friedlin
853418 Saccharomyces cerevisiae S288c
100135840 Oncorhynchus mykiss
379756 Xenopus laevis
464733 Pan troglodytes
703193 Macaca mulatta
100015941 Monodelphis domestica
100599238 Nomascus leucogenys
397850 Xenopus laevis
3309 Homo sapiens
415113 Bos taurus
396487 Gallus gallus
100731108 Cavia porcellus
407060 Sus scrofa
480726 Canis lupus familiaris
780447 Ovis aries
14828 Mus musculus
25617 Rattus norvegicus
378848 Danio rerio
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