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Browse our PTPN1 Proteins (PTPN1)

Full name:
Protein tyrosine Phosphatase, Non-Receptor Type 1 Proteins (PTPN1)
On are 22 Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) Proteins from 12 different suppliers available. Additionally we are shipping PTPN1 Antibodies (236) and PTPN1 Kits (29) and many more products for this protein. A total of 300 PTPN1 products are currently listed.
CPTP1, Ptp, PTP-1B, PTP-HA2, ptp1b, PTPN1, wu:fk54h03
list all proteins Gene Name GeneID UniProt
PTPN1 5770 P18031
PTPN1 19246 P35821
PTPN1 24697 P20417

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PTPN1 Proteins (PTPN1) by Origin

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Top referenced PTPN1 Proteins

  1. Human PTPN1 Protein expressed in Escherichia coli (E. coli) - ABIN2002547 : Frangioni, Beahm, Shifrin, Jost, Neel: The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. in Cell 1992 (PubMed)
    Show all 4 references for ABIN2002547

  2. Human PTPN1 Protein expressed in Escherichia coli (E. coli) - ABIN666832 : Chernoff, Schievella, Jost, Erikson, Neel: Cloning of a cDNA for a major human protein-tyrosine-phosphatase. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)

More Proteins for PTPN1 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) interaction partners

  1. stimulation of the DOCK180 (show DOCK1 Proteins) pathway represents an alternative mechanism of PTP1B inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 (show KDR Proteins) activation as a prerequisite.

  2. Overexpression of PTP1B is associated with breast neoplasms.

  3. The analysis revealed three candidate genes GSK3B, PTPN1, STX4 (show STX4 Proteins) that are differentially expressed in study subjects. GSK3B was highly significant in Ps-T2D (P=0.00018, FR=-26.6), followed by Ps (P=0.0028, FR=-14.5) and T2D groups (P=0.032, FR=-5.9). PTPN1 showed significant association only with PS-T2D (P=0.00027, FR=-8.5). STX4 (show STX4 Proteins) showed significant association with both Ps (P=0.0002, FR=-20) and Ps-T2D (P=0.0016, FR=-11.2).

  4. LPS (show IRF6 Proteins) tolerance interferes with TLR4 (show TLR4 Proteins) signaling by inhibiting Lyn (show LYN Proteins) and c-Src (show SRC Proteins) phosphorylation and their recruitment to TLR4 (show TLR4 Proteins), while increasing the phosphatase activity and expression of PP2A (show PPP2R4 Proteins), PTPN22 (show PTPN22 Proteins), PTP1B and MKP1 (show DUSP1 Proteins).

  5. PTP1B directly regulates STAT5 (show STAT5A Proteins) phosphorylation and its activation via the cAMP/PKA pathway downstream of the 5-HT7 (show HTR7 Proteins) receptor is involved in the suppression of beta-casein (show CSN2 Proteins) expression in MCF-12A cells

  6. On EGF (show EGF Proteins) stimulation, complexes containing Mena (show EGFR Proteins) and PTP1B are recruited to the EGFR (show EGFR Proteins), causing receptor dephosphorylation and leading to decreased motility responses.

  7. PTP1B dephosphorylates PITX1 (show PITX1 Proteins) to weaken its protein stability and the transcriptional activity for p120RasGAP (show RASA1 Proteins) gene expression

  8. our data indicate that by targeting PTP1B, miR (show MLXIP Proteins)-744 plays a feed-forward role in regulating type I IFN signaling pathway.

  9. O-GlcNAcylation of PTP1B can influence insulin (show INS Proteins) signal transduction by modulating its own phosphatase activity, which participates in the process of hepatic insulin (show INS Proteins) resistance.

  10. Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcomes imatinib-resistance of K562 cells.

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) interaction partners

  1. Taken together, the data presented here suggest that PTP1B is essential for proper differentiation of ES cells into cardiomyocytes.

  2. This study demonstrates that PTP1B is an important positive regulator of neuroinflammation

  3. Cudrania tricuspidata leaves (CTe) had a strong inhibitory effect on PTP1B activity and substantially inhibited fat accumulation in 3T3-L1 cells

  4. Deletion of Ptp1b in POMC (show POMC Proteins) neurons protects from leptin (show LEP Proteins)- and sympatho-mediated increases in BP.

  5. these data provide first evidence for a key regulatory role for PTP1B in mediating a central dendritic cells function of initiating adaptive immune responses in response to innate immune cell activation.

  6. These findings indicated that improvement of insulin (show INS Proteins) sensitivity and hypoglycemic effects of ME may be attributed to the inhibition of PTP1B. Thereby, we pioneered the inhibitory potential of ME targeted on PTP1B as anti-T2DM drug discovery.

  7. This study presents PTP1B as a mechanism-based therapeutic target for RTT, validating a unique strategy for treating the disease by modifying signal transduction pathways with small-molecule drugs.

  8. Studied the liver-specific role of PTP1B in GH signaling.

  9. Superoxide anion radicals induce IGF-1 resistance through activation of PTP1B and PTEN.

  10. Fumosorinone increased glucose uptake and improved insulin (show INS Proteins) resistance by down-regulating the expression of PTP1B and activating the insulin (show INS Proteins) signaling pathway, suggesting that it may possess antidiabetic properties.

PTPN1 Protein Profile

Protein Summary

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Alternative names and synonyms associated with PTPN1

  • protein tyrosine phosphatase, non-receptor type 1 (PTPN1)
  • protein tyrosine phosphatase, non-receptor type 1 (Ptpn1)
  • protein tyrosine phosphatase, non-receptor type 1 (ptpn1)
  • CPTP1 protein
  • Ptp protein
  • PTP-1B protein
  • PTP-HA2 protein
  • ptp1b protein
  • PTPN1 protein
  • wu:fk54h03 protein

Protein level used designations for PTPN1

protein tyrosine phosphatase, non-receptor type 1 , tyrosine-protein phosphatase non-receptor type 1 , tyrosine-protein phosphatase non-receptor type 1-like , protein tyrosine phosphatase, placental , protein-tyrosine phosphatase 1B , protein-protein-tyrosine phosphatase HA2 , protein-tyrosine phosphatase HA2 , PTP-1B , fk54h03 , protein tyrosine phosphatase 1b , non-receptor protein tyrosine phosphatase , phosphoprotein phosphatase , tyrosine phosphatase 1B

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100354834 Oryctolagus cuniculus
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100481720 Ailuropoda melanoleuca
5770 Homo sapiens
19246 Mus musculus
24697 Rattus norvegicus
30081 Danio rerio
444514 Xenopus laevis
395688 Gallus gallus
477263 Canis lupus familiaris
396667 Sus scrofa
508658 Bos taurus
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