Browse our PTPN1 Proteins (PTPN1)

Full name:
Protein tyrosine Phosphatase, Non-Receptor Type 1 Proteins (PTPN1)
On www.antibodies-online.com are 22 Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) Proteins from 11 different suppliers available. Additionally we are shipping PTPN1 Antibodies (251) and PTPN1 Kits (36) and many more products for this protein. A total of 322 PTPN1 products are currently listed.
Synonyms:
CPTP1, Ptp, PTP-1B, PTP-HA2, ptp1b, PTPN1, wu:fk54h03
list all proteins Gene Name GeneID UniProt
PTPN1 5770 P18031
PTPN1 19246 P35821
PTPN1 24697 P20417

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PTPN1 Proteins (PTPN1) by Origin

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Top referenced PTPN1 Proteins

  1. Human PTPN1 Protein expressed in Escherichia coli (E. coli) - ABIN2002547 : Frangioni, Beahm, Shifrin, Jost, Neel: The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. in Cell 1992 (PubMed)
    Show all 4 references for 2002547

  2. Human PTPN1 Protein expressed in Escherichia coli (E. coli) - ABIN666832 : Chernoff, Schievella, Jost, Erikson, Neel: Cloning of a cDNA for a major human protein-tyrosine-phosphatase. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)

More Proteins for PTPN1 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) interaction partners

  1. Data suggest TrxR1 (show TXNRD1 Proteins) and NADPH (show NQO1 Proteins) directly protect PTP1B from inactivation by oxidation; this protection is independent of TRX1 (show MLL Proteins) and PRX2 (show PRDX2 Proteins); this protection is blocked by auranofin (an inhibitor of TrxR1 (show TXNRD1 Proteins) and requires an intact selenocysteine residue in TrxR1 (show TXNRD1 Proteins). (TrxR1 (show TXNRD1 Proteins) = thioredoxin reductase 1 (show TXNRD1 Proteins); PTP1B = protein tyrosine phosphatase (show ACP1 Proteins), non-receptor type 1; TRX1 (show MLL Proteins) = thioredoxin-1; PRX2 (show PRDX2 Proteins) = paired related homeobox 2 (show PRRX2 Proteins) protein)

  2. Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.

  3. PTP1B was overexpressed in over 70% of breast cancer tissues, correlating with patients with estrogen receptor (ER (show ESR1 Proteins))-negative, progesterone receptor (PR (show PGR Proteins))-negative, and human epidermal growth factor receptor (show EGFR Proteins) 2 (HER2 (show ERBB2 Proteins))-positive tumors. The data also showed that both tumor size and lymph node metastasis were significantly higher in patients with a higher level of PTP1B.

  4. PTP1B uses conformational and dynamic allostery to regulate its activity. Both conformational rigidity and dynamics are essential for controlling protein activity.

  5. PTP1BDelta6 is a positive regulator of JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling in classical Hodgkin lymphoma cells.(

  6. In PTP1B and VHR (show DUSP3 Proteins), two new allosteric clusters were identified in each enzyme.

  7. PTP1B/RNF213 (show RNF213 Proteins)/alpha-KGDD pathway is critical for survival of HER2 (show ERBB2 Proteins)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment

  8. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  9. Data show that cichoric acid (CHA (show TCFL5 Proteins)) is a competitive inhibitor that binds in the active site of protein tyrosine phosphatase 1B (PTP1B), and chlorogenic acid (CGA (show CGA Proteins)), while a noncompetitive inhibitor, binds in the second aryl phosphate binding site, rather than the predicted benzfuran binding pocket.

  10. stimulation of the DOCK180 (show DOCK1 Proteins) pathway represents an alternative mechanism of PTP1B inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 (show KDR Proteins) activation as a prerequisite.

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) interaction partners

  1. The results suggest a deficiency of PTP1B improves hypothalamic insulin (show INS Proteins) sensitivity resulting in the attenuation of AgRP (show AGRP Proteins) mRNA expression under HFD conditions.

  2. cadherin 2 (CDH2 (show CDH2 Proteins)) and CDH4 (show CDH4 Proteins) cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and alpha- and beta-catenins.

  3. this paper shows that PTP1B specifically regulates IgE-mediated STAT5 (show STAT5A Proteins) pathway, but is redundant in influencing mast cell function in vivo

  4. PTP1B/RNF213 (show RNF213 Proteins)/alpha-KGDD pathway is critical for survival of HER2 (show ERBB2 Proteins)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment

  5. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  6. These findings reveal a novel role for pancreatic PTP1B in cerulein- and arginine-induced acute pancreatitis.

  7. POMC (show POMC Proteins)-Ptp1b deletion increases plasma TNF-alpha (show TNF Proteins) levels

  8. Data show that protein tyrosine phosphatase 1B (PTP1B)-deficiency enhanced JAK2 (show JAK2 Proteins)-STAT3 (show STAT3 Proteins) signaling in hypothalamic microglia and attenuated inflammation.

  9. Taken together, the data presented here suggest that PTP1B is essential for proper differentiation of ES cells into cardiomyocytes.

  10. This study demonstrates that PTP1B is an important positive regulator of neuroinflammation

Cow (Bovine) Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) interaction partners

  1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

PTPN1 Protein Profile

Protein Summary

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Alternative names and synonyms associated with PTPN1

  • protein tyrosine phosphatase, non-receptor type 1 (PTPN1)
  • protein tyrosine phosphatase, non-receptor type 1 (Ptpn1)
  • protein tyrosine phosphatase, non-receptor type 1 (ptpn1)
  • CPTP1 protein
  • Ptp protein
  • PTP-1B protein
  • PTP-HA2 protein
  • ptp1b protein
  • PTPN1 protein
  • wu:fk54h03 protein

Protein level used designations for PTPN1

protein tyrosine phosphatase, non-receptor type 1 , tyrosine-protein phosphatase non-receptor type 1 , tyrosine-protein phosphatase non-receptor type 1-like , protein tyrosine phosphatase, placental , protein-tyrosine phosphatase 1B , protein-protein-tyrosine phosphatase HA2 , protein-tyrosine phosphatase HA2 , PTP-1B , fk54h03 , protein tyrosine phosphatase 1b , non-receptor protein tyrosine phosphatase , phosphoprotein phosphatase , tyrosine phosphatase 1B

GENE ID SPECIES
469970 Pan troglodytes
702016 Macaca mulatta
100172151 Pongo abelii
100354834 Oryctolagus cuniculus
100387823 Callithrix jacchus
100481720 Ailuropoda melanoleuca
5770 Homo sapiens
19246 Mus musculus
24697 Rattus norvegicus
30081 Danio rerio
444514 Xenopus laevis
395688 Gallus gallus
477263 Canis lupus familiaris
396667 Sus scrofa
508658 Bos taurus
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