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Browse our SARM1 Proteins (SARM1)

Full name:
Sterile alpha and TIR Motif Containing 1 Proteins (SARM1)
On are 3 Sterile alpha and TIR Motif Containing 1 (SARM1) Proteins from 2 different suppliers available. Additionally we are shipping SARM1 Antibodies (51) and many more products for this protein. A total of 59 SARM1 products are currently listed.
A830091I15Rik, C78606, MyD88-5, MyD885, SAMD2, SARM
list all proteins Gene Name GeneID UniProt
SARM1 237868 Q6PDS3
SARM1 23098 Q6SZW1
Rat SARM1 SARM1 287545  

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SARM1 Proteins (SARM1) by Origin

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More Proteins for SARM1 Interaction Partners

Mouse (Murine) Sterile alpha and TIR Motif Containing 1 (SARM1) interaction partners

  1. Sarm1(-/-)mice developed fewer Beta-amyloid precursor protein aggregates in axons of corpus callosum after traumatic brain injury.

  2. MMP-12 (show MMP12 Proteins) up-regulation mediated by SARM-TRIF (show RNF138 Proteins) signaling pathway contributes to IFN-gamma (show IFNG Proteins)-independent airway inflammation and AHR (show AHR Proteins) post RSV infection in nude mice.

  3. SARM1, Not MyD88 (show MYD88 Proteins), Mediates TLR7 (show TLR7 Proteins)/TLR9 (show TLR9 Proteins)-Induced Apoptosis in Neurons

  4. nicotinamide mononucleotide adenylyltransferase 2 (show NMNAT2 Proteins)-depletion-dependent degeneration of established axons and restricted extension of developing axons are thus both SARM1 dependent

  5. SARM1-induced depletion of NAD(+) may explain the potent axon protection in Wallerian degeneration slow (Wld(s)) mutant mice.

  6. The findings suggest that Sarm1 regulates social behaviors and cognition.

  7. Therefore, Sarm1 functions downstream of ROS (show ROS1 Proteins) to induce neuronal cell death and axon degeneration during oxidative stress.

  8. SARM expression was reduced and TRIF (show RNF138 Proteins) expression was increased after respiratory syncytial virus infection.

  9. this study identifies a new role for SARM in CCL5 (show CCL5 Proteins) expression in macrophages.

  10. Wild-type LPS (show TLR4 Proteins) is able to upregulate SARM and to prevent SIRPalpha downregulation.

Human Sterile alpha and TIR Motif Containing 1 (SARM1) interaction partners

  1. Active nerve degeneration requires SARM1 and MAP kinases, including DLK (show DAPK3 Proteins), while the NAD+ synthetic enzyme NMNAT2 (show NMNAT2 Proteins) prevents degeneration.

  2. Data show that sterile alpha- and armadillo-motif-containing protein (SARM) modulates MyD88 protein-mediated Toll-like receptors (TLRs) activation through BB-loop dependent interleukin-1 receptor (TIR) TIR-TIR interactions.

  3. These results indicate that association of PINK1 (show PINK1 Proteins) with SARM1 and TRAF6 (show TRAF6 Proteins) is an important step for mitophagy.

  4. The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.

  5. Rapid Wallerian degeneration requires the pro-degenerative molecules SARM1.

  6. Data found that the UXT (show UXT Proteins) isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis.

  7. SARM overexpression caused mitochondrial clustering which has also been observed in several cell death phenomenon.

  8. The N-terminal 27 amino acids (S27 (show RPS27 Proteins)) of SARM, which is hydrophobic and polybasic, acts as a mitochondria-targeting signal sequence, associating SARM to the mitochondria. The S27 (show RPS27 Proteins) peptide has an inherent ability to bind to lipids and mitochondria.

  9. SARM-mediated inhibition may not be exclusively directed at TRIF (show TRIM69 Proteins) or MyD88 (show MYD88 Proteins), but that SARM may also directly inhibit MAPK (show MAPK1 Proteins) phosphorylation

  10. TIR adaptor SARM is a negative regulator of Toll (show TLR4 Proteins)-like receptor signaling.

SARM1 Protein Profile

Protein Summary

Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation (By similarity).

Alternative names and synonyms associated with SARM1

  • sterile alpha and TIR motif containing 1 (SARM1)
  • sterile alpha and TIR motif containing 1 (LOC100349344)
  • sterile alpha and HEAT/Armadillo motif containing 1 (Sarm1)
  • sterile alpha and TIR motif containing 1 (Sarm1)
  • sterile alpha and TIR motif containing 1 (sarm1)
  • A830091I15Rik protein
  • C78606 protein
  • MyD88-5 protein
  • MyD885 protein
  • SAMD2 protein
  • SARM protein

Protein level used designations for SARM1

sterile alpha and TIR motif-containing protein 1 , sterile alpha and TIR motif containing 1 , Tir-1 homolog , SAM domain-containing protein 2 , sterile alpha and Armadillo repeat protein , sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila , sterile alpha motif domain-containing protein 2 , tir-1 homolog

491165 Canis lupus familiaris
100059075 Equus caballus
536256 Bos taurus
100349344 Oryctolagus cuniculus
237868 Mus musculus
23098 Homo sapiens
287545 Rattus norvegicus
403143 Danio rerio
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