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phylogenetic analysis of the cytoplasmic regions of TLR genes suggested that the signal transduction pathway of TLR10 was different from those of TLR1 (show TLR1 Proteins) and TLR6 (show TLR6 Proteins)
A TLR10 allelic variant, I473T, has impaired NFkB inhibitory activity and is highly associated with disease severity and low response to infliximab in patients with rheumatoid arthritis
The data demonstrate that TLR10 is a novel regulator of innate immune responses and of the differentiation of primary human monocytes into effective dendritic cells.
these results demonstrate that TLR10 functions as a broad negative regulator of TLR signaling
Our results demonstrate that TLR10 has a functional role within the B cell lineage that is distinct from that of other TLR family members
Study concludes that genetic variation in the TLR10-TLR1-TLR6 (show TLR6 Proteins) gene cluster mediates responsiveness to organic dust, but indicates different signaling pathways for IL-6 (show IL6 Proteins) and TNF-alpha (show TNF Proteins). These studies provide new insight into the role of the TLR10-TLR1-TLR6 (show TLR6 Proteins) gene cluster and the innate immune response to organic dust.
Our results suggest that TLR10 is involved in the recognition of FSL-1 (show FSTL1 Proteins), LPS (show IRF6 Proteins), and flagellin (show FliC Proteins) and TLR-ligand-induced expression of TNF-alpha (show TNF Proteins) does not depend on TLR10.
Data indicate that polymorphisms in toll like receptor 10 (TLR10) are not associated with chronic Q fever.
Study annotated variants at 4p14 as expression quantitative trait loci (eQTL (show EQTN Proteins)) associated with TLR6 (show TLR6 Proteins)/10 and FAM114A1 (show FAM114A1 Proteins); findings suggest that 4p14 polymorphisms are linked to host immune response to H. pylori infection but not to its acquisition.
concluded that TLR-1 (show TLR1 Proteins) rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease
genetic variants in TLR10 are associated with protection against complicated skin and skin structure infections
The expression analysis showed similar expression profiles for TLR1 (show TLR1 Proteins) and TLR6 (show TLR6 Proteins), which indicate a co-regulation of these two genes, TLR10 had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 (show TLR1 Proteins) and TLR6 (show TLR6 Proteins).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
toll-like receptor 10
, toll-like receptor 10-like