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Browse our anti-HFE (HFE) Antibodies

Full name:
anti-Hemochromatosis Antibodies (HFE)
On are 74 Hemochromatosis (HFE) Antibodies from 16 different suppliers available. Additionally we are shipping HFE Proteins (15) and HFE Kits (1) and many more products for this protein. A total of 97 HFE products are currently listed.

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Top referenced anti-HFE Antibodies

  1. Human Monoclonal HFE Primary Antibody for IF, WB - ABIN395159 : Lehmann, Schuur, Warden, Hammond, Belbin, Kölsch, Lehmann, Wilcock, Brown, Kehoe, Morris, Barker, Coto, Alvarez, Deloukas, Mateo, Gwilliam, Combarros, Arias-Vásquez, Aulchenko, Ikram, Breteler, van Duijn, Oulhaj, Heun, Cortina-Borja, Morgan, Robson, Smith: Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project. in Neurobiology of aging 2011 (PubMed)
    Show all 5 references for ABIN395159

  2. Human Monoclonal HFE Primary Antibody for ICC, ELISA - ABIN969192 : Hosgood, Menashe, He, Chanock, Lan: PTEN identified as important risk factor of chronic obstructive pulmonary disease. in Respiratory medicine 2009 (PubMed)
    Show all 2 references for ABIN969192

  3. Human Polyclonal HFE Primary Antibody for IHC (p), WB - ABIN390457 : Valenti, Girelli, Valenti, Castagna, Como, Campostrini, Rametta, Dongiovanni, Messa, Fargion: HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients. in Clinical journal of the American Society of Nephrology : CJASN 2009 (PubMed)
    Show all 2 references for ABIN390457

  4. Human Polyclonal HFE Primary Antibody for EIA, WB - ABIN453091 : Won, Jeong, Chung, Lee, Hwang, Kim, Lee, Kim, Park, Lee, Kim: Hepatic iron, serum ferritin, HFE mutation, and hepatic fibrosis in chronic hepatitis C. in Intervirology 2009 (PubMed)
    Show all 2 references for ABIN453091

  5. Human Polyclonal HFE Primary Antibody for IHC, IHC (p) - ABIN4317233 : Lenarduzzi, Hui, Yue, Ito, Shi, Williams, Bruce, Sakemura-Nakatsugawa, Xu, Schimmer, Liu: Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer. in PLoS ONE 2013 (PubMed)

  6. Cow (Bovine) Polyclonal HFE Primary Antibody for IHC, WB - ABIN2781800 : Gleeson, Evans, Bradley, Jones, Peck, Dube, Rigby, Dalton: HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls. in The American journal of gastroenterology 2006 (PubMed)

More Antibodies against HFE Interaction Partners

Human Hemochromatosis (HFE) interaction partners

  1. The results show an association between presence of one or both H63D alleles and development of BIP (show GDF10 Antibodies) in testicular cancer patients treated with bleomycin combination chemotherapy.

  2. C282Y but not H63D mutation of HFE was related to elevated cancer risk.

  3. Rare HFE variants are therefore the most frequent cause of hemochromatosis in non-C282Y homozygote HFE patients

  4. in Greek population cohort the frequencies of polymorphism were as follows: rs1800562: GG (wildtype)=97.0%, GA=1.5%,AA=1.5%; rs1799945: CC (wildtype)=74.4%, CG=23.4%, GG=2.2%; rs1800730:AA (wildtype)=98.1%, AT=1.5% and TT=0.4%. No association between the HFE polymorphisms rs1800562, rs1799945 and rs1800730 and gender could be established.

  5. In conclusion, our metaanalysis showed a marginal higher prevalence of H63D variant of the HFE gene in alcoholic liver disease but did not support an increased risk of C282Y mutation.

  6. HFE gene mutations are effective on iron deposition in the liver in sickle cell disease patients. In patients for whom recurrent erythrocyte transfusions are required, genotyping of the HFE gene will be helpful while management with chelating agents is being planned.

  7. The HFE genotype may predict myelodysplastic syndrome prognosis and there is a need for further studies. It remains a challenging question if HFE mutated myelodysplastic syndrome patients should be considered for potent iron chelation therapy.

  8. C282Y homozygotes referred for HFE testing commonly have a GNPAT (show GNPAT Antibodies) variant. This GNPAT (show GNPAT Antibodies) variant does not appear be a co-modifying gene affecting expression of HFE related hemochromatosis in this population. The GNPAT (show GNPAT Antibodies) variant does not predict the severity of iron overload.

  9. In this study, HFE p.282Y variant (rs1800562 A allele) was significantly associated with the risk of varicose veins (OR 1.79, 95 % CI = 1.11-2.89, P = 0.02).

  10. Statistically significant differences were observed for genotype distribution of C282Y and H63D between the general population and the patients diagnosed with hereditary hemochromatosis.

Mouse (Murine) Hemochromatosis (HFE) interaction partners

  1. unlike homozygous Hfe deletion, heterozygous gene deletion disrupted glucose homeostasis but did not affect lipid metabolism or liver injury.

  2. Single Hjv (show HFE2 Antibodies)(-)/(-) and double Hfe(-)/(-)Hjv (show HFE2 Antibodies)(-)/(-) mice exhibit comparable iron overload. Hfe and Hjv (show HFE2 Antibodies) regulate hepcidin (show HAMP Antibodies) via the same pathway.

  3. Results show that HFE requires HJV (show HFE2 Antibodies) to activate downstream signal transduction pathways for hepcidin (show HAMP Antibodies) regulation.

  4. Alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD.

  5. results provide evidence that HFE induces hepcidin (show HAMP Antibodies) expression via the BMP pathway: HFE interacts with ALK3 (show BMPR1A Antibodies) to stabilize ALK3 (show BMPR1A Antibodies) protein and increase ALK3 (show BMPR1A Antibodies) expression at the cell surface.

  6. These results support in vivo studies which suggest that Hfe and Tfr2 (show TFR2 Antibodies) can independently regulate hepcidin (show HAMP Antibodies).

  7. A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.

  8. Hfe-knockout mice did not have higher brain iron levels than wildtype controls.

  9. Hfe(-/-) retinal pigment epithelial cells exhibited slower senescence rate and higher survivin (show BIRC5 Antibodies) expression than wild type cells. Hfe(-/-) cells migrated faster and showed greater glucose uptake and increased expression of GLUTs.

  10. Findings suggest a novel role for Hfe and/or imbalanced iron homeostasis in the regulation of the inflammatory response in the lung and hereditary hemochromatosis.

HFE Antigen Profile

Antigen Summary

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Alternative names and synonyms associated with HFE

  • hemochromatosis (HFE) antibody
  • hemochromatosis (Hfe) antibody
  • HFE1 antibody
  • HH antibody
  • HLA-H antibody
  • MR2 antibody
  • MVCD7 antibody
  • TFQTL2 antibody

Protein level used designations for anti-Hemochromatosis (HFE) Antibodies

MHC class I-like protein HFE , hereditary hemochromatosis protein , hereditary hemochromatosis protein HLA-H , high Fe , RT1-CAFE , hereditary hemochromatosis protein homolog , hemochromatosis protein

3077 Homo sapiens
497622 Bos taurus
29199 Rattus norvegicus
15216 Mus musculus
462489 Pan troglodytes
100688951 Canis lupus familiaris
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