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VHL Proteins

(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

recommended

VHL Protein (AA 1-172) (GST tag) (ABIN1325000)

VHL Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

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recommended

VHL Protein (AA 1-213) (Strep Tag) (ABIN3075417)

Crystallography grade VHL Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA

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recommended

VHL Protein (AA 1-213) (His tag) (ABIN7424887)

VHL Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % WB, SDS, Imm, PC

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VHL Proteins by Grade

Find VHL Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

VHL Proteins by Origin

Find VHL Proteins for a variety of species such as anti-Human VHL, anti-Dog VHL, anti-Rat VHL. The species listed below are among those available. Click on a link to go to the corresponding products.

VHL Proteins by Source

Here you will find VHL Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

VHL Proteins by Protein Type

Here you can find VHL Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

VHL Proteins by Application

Find VHL Proteins validated for a specific application such as WB, ELISA, SDS, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular VHL Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

VHL Protein (AA 1-172) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1325000

Quantity 10 μg

Datasheet Datasheet

VHL Protein (AA 1-213) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3075417

Quantity 1 mg

Datasheet Datasheet

VHL Protein (AA 1-213) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7424887

Quantity 100 μg

Datasheet Datasheet

VHL Protein (AA 6-175) (His tag)

Reactivity Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7409467

Quantity 100 μg

Datasheet Datasheet

VHL Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2735257

Quantity 20 μg

Datasheet Datasheet

VHL Protein (AA 1-219) (His tag)

Reactivity Dog

Source Yeast

Validations

Cat. No. ABIN1634750

Quantity 1 mg

Datasheet Datasheet

Latest Publications for our VHL Proteins

Kim, Lee, Jang, Yi, Kim, Han, Lee, Tong, Vincelette, Gao, Yin, Evans, Choi, Qin, Liu, Zhang, Deng, Jen, Zhang, Wang, Lou: "WSB1 promotes tumor metastasis by inducing pVHL degradation." in: Genes & development, Vol. 29, Issue 21, pp. 2244-57, (2015) (PubMed).

Aliases for VHL Proteins

von Hippel-Lindau tumor suppressor (VHL) Proteins
von Hippel-Lindau (Vhl) Proteins
von Hippel-Lindau tumor suppressor (vhl) Proteins
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL) Proteins
von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992) Proteins
von Hippel-Lindau tumor suppressor (Vhl) Proteins
BcDNA:RH61560 Proteins
CG13221 Proteins
d-VHL Proteins
d-vhl Proteins
Dmel\\CG13221 Proteins
dmVHL Proteins
DVhl Proteins
Dvhl Proteins
dVHL Proteins
HRCA1 Proteins
hrca1 Proteins
pVHL Proteins
RCA1 Proteins
rca1 Proteins
VHL Proteins
vhl Proteins
VHL1 Proteins
vhl1 Proteins
Vhlh Proteins
zgc:158722 Proteins

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VHL Proteins by Grade

VHL Proteins by Origin

VHL Proteins by Source

VHL Proteins by Protein Type

VHL Proteins by Application

Popular VHL Proteins

Latest Publications for our VHL Proteins

Aliases for VHL Proteins

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