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VHL Products

(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))

Categories

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

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Featured VHL Categories

VHL Antibodies

High quality antibodies with extensive validation data.

VHL ELISA Kits

Reliable ELISA kits for a wide range of species.

VHL Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended VHL Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IHC (p), IP, ICC
Validations
  • (1)
  • (8)
Cat. No. ABIN2854928
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
  • (6)
Cat. No. ABIN3020968
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, FACS, IF, IHC (p)
Validations
  • (7)
Cat. No. ABIN390462
Quantity 200 μL
Datasheet Datasheet

Recommended VHL ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971170
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960511
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN585359
Quantity 96 tests
Datasheet Datasheet

Recommended VHL Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1325000
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424887
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7409467
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our VHL products

Li, Qu, Jin, Guo, Wang, Qi, Yang, Zhang, Li: "Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis." in: Scientific reports, Vol. 6, pp. 32131, (2018) (PubMed).

Gao, Wu, Xie, Li, Mao, Duan, Han, Han, Yu, Lu, Yang, Xu, Xia, Chen, Wang: "VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2." in: Nature communications, Vol. 8, pp. 15337, (2018) (PubMed).

Guo, Qi, Yang, Wang, Wang, Li, Li, Qu, Wang, Han: "Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts." in: Cell and tissue research, Vol. 367, Issue 2, pp. 197-211, (2017) (PubMed).

Liu, Cai, Hu, Mei, Zhang, Ouyang, Wang, Zhang, Xiao: "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)." in: The Journal of biological chemistry, Vol. 291, Issue 49, pp. 25692-25705, (2017) (PubMed).

Lee, Frattini, Bansal, Castano, Sherman, Hutchinson, Bruce, Califano, Liu, Cardozo, Iavarone, Lasorella: "An ID2-dependent mechanism for VHL inactivation in cancer." in: Nature, Vol. 529, Issue 7585, pp. 172-7, (2016) (PubMed).

Kim, Lee, Jang, Yi, Kim, Han, Lee, Tong, Vincelette, Gao, Yin, Evans, Choi, Qin, Liu, Zhang, Deng, Jen, Zhang, Wang, Lou: "WSB1 promotes tumor metastasis by inducing pVHL degradation." in: Genes & development, Vol. 29, Issue 21, pp. 2244-57, (2015) (PubMed).

Alahari, Post, Caniggia: "Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta." in: Endocrinology, Vol. 156, Issue 8, pp. 3012-25, (2015) (PubMed).

Shao, Zhang, Yang, Qi, Zhang, Deng: "HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression." in: In vitro cellular & developmental biology. Animal, Vol. 51, Issue 8, pp. 808-14, (2015) (PubMed).

Cho, Kaowinn, Moon, Soh, Kang, Jung, Oh, Song, Koh, Chung: "Oncotropic H-1 parvovirus infection degrades HIF-1α protein in human pancreatic cancer cells independently of VHL and RACK1." in: International journal of oncology, Vol. 46, Issue 5, pp. 2076-82, (2015) (PubMed).

Du, Zhang, Zhang, Ouyang, Wang, Liu, Li, Ji, Liu, Xiao: "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1782-90, (2015) (PubMed).

Synonyms and alternative names related to VHL

von Hippel-Lindau tumor suppressor (VHL), von Hippel-Lindau (Vhl), von Hippel-Lindau tumor suppressor (vhl), von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL), von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992), von Hippel-Lindau tumor suppressor (Vhl), BcDNA:RH61560, CG13221, d-VHL, d-vhl, Dmel\\CG13221, dmVHL, DVhl, Dvhl, dVHL, HRCA1, hrca1, pVHL, RCA1, rca1, VHL, vhl, VHL1, vhl1, Vhlh, zgc:158722

Protein level used designations for VHL

  • elongin binding protein
  • protein G7
  • von Hippel-Lindau disease tumor suppressor
  • CG13221-PA
  • CG13221-PB
  • Vhl-PA
  • Vhl-PB
  • von hippel lindau
  • von hippel lindau protein
  • pVHL
  • von Hippel-Lindau tumor suppressor
  • von Hippel-Lindau syndrome homolog
  • von Hippel-Lindau syndrome protein homolog
  • Von Hippel-Lindau disease tumor suppressor
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