Browse our CSNK1A1 Proteins (CSNK1A1)

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Casein Kinase 1, alpha 1 Proteins (CSNK1A1)
On are 21 Casein Kinase 1, alpha 1 (CSNK1A1) Proteins from 8 different suppliers available. Additionally we are shipping CSNK1A1 Antibodies (142) and CSNK1A1 Kits (6) and many more products for this protein. A total of 183 CSNK1A1 products are currently listed.
2610208K14Rik, 4632404G05Rik, 5430427P18Rik, anon-WO03040301.93, anon-WO03040301.95, CG2028, CHUNP6894, CK-II, ck1, ck1a, ck1alpha, CKI, CK I, CkIa, CKIALPHA, CKI alpha, Csnk1a, CSNK2A1, dmCK1, dmckI, Dmel\\CG2028, EHK, EHK1, EPPK, HLCDGP1, K1, KER1, KRT1A, l(1)G0492, NEPPK, PKA-C, PRO2975, wu:fb65a02, wu:fi30h04, wu:fj19c11, zgc:92158
list all proteins Gene Name GeneID UniProt
CSNK1A1 1452 P48729
CSNK1A1 93687  
CSNK1A1 113927 P97633

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CSNK1A1 Proteins (CSNK1A1) by Origin

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Top referenced CSNK1A1 Proteins

  1. Human CSNK1A1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003196 : Dubois, Kerai, Zemlickova, Howell, Jackson, Venkateswarlu, Cullen, Theibert, Larose, Roach, Aitken: Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins. in The Journal of biological chemistry 2001 (PubMed)
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More Proteins for CSNK1A1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Casein Kinase 1, alpha 1 (CSNK1A1) interaction partners

  1. we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.

  2. Expected genes in the Scar-Arp2 (show ACTR2 Proteins)/3 actin (show ACTB Proteins) nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature.

  3. CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser (show SIGLEC1 Proteins) and Thr (show TRH Proteins) residues in the N-terminus and targeting it for degradation.

  4. 2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways

  5. expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm

  6. doubletime and CKII (show CSNK2A1 Proteins) kinases collaborate to potentiate Drosophila PER transcriptional repressor activity

  7. Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.

  8. Mutation of ck1alpha or -epsilon or sgg/gsk3beta in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.

Human Casein Kinase 1, alpha 1 (CSNK1A1) interaction partners

  1. Disruption of CK1alpha function in myeloma cells resulted in decreased Mdm2 (show MDM2 Proteins), increased p53 (show TP53 Proteins) and p21 (show CDKN1A Proteins) and reduced expression of beta-catenin (show CTNNB1 Proteins) and AKT (show AKT1 Proteins).

  2. CK1delta enhances EPO (show EPO Proteins) secretion from liver cancer cells under hypoxia by modifying HIF-2alpha (show EPAS1 Proteins) and promoting its nuclear accumulation.

  3. CKIalpha-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII (show CAMK2G Proteins) gamma and delta may have negative roles in the HCV life cycle.

  4. Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis (show LBR Proteins).

  5. KRT1 (show KRT1 Proteins) played an important role of maintaining epithelial barrier and its down-regulation in intestinal tissue was correlated with the progression of inflammatory bowel disease.

  6. Report genetic/clinical spectrum of KRT1 (show KRT1 Proteins) mutations in keratinopathic ichthyosis (show LBR Proteins).

  7. Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.

  8. demonstrated the presence of a genetic cutaneous mosaicism. Both patients carry the KRT1 (show KRT1 Proteins) pI479T substitution, but in the palmoplantar areas of one of them, only the mutated allele is expressed (hemizygous). This leads to highlight a new type of cutaneous mosaic, the palmoplantar mosaicism

  9. study focuses on, how the structural dynamics and conformational changes of two CK1 (show CSNK1A1L Proteins) isoforms are synchronized in carcinogenic pathway

  10. NIFK (show MKI67IP Proteins) is required for lung cancer progression via the RUNX1 (show RUNX1 Proteins)-dependent CK1alpha repression, which activates TCF4 (show TCF4 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in metastasis and the Ki-67 (show MKI67 Proteins)-dependent regulation in cell proliferation.

Mouse (Murine) Casein Kinase 1, alpha 1 (CSNK1A1) interaction partners

  1. Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.

  2. Phosphorylation of LRRK2 (show LRRK2 Proteins) by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7 (show ARHGEF7 Proteins).

  3. Phosphorylation of FADD (show FADD Proteins) by the kinase CK1alpha promotes KRASG12D-induced lung cancer.

  4. Csnk1a1 knockdown results in decreased Rps6 (show RPS6 Proteins) phosphorylation, increased p53 (show TP53 Proteins) activity, and myeloid differentiation.

  5. study for the first time demonstrates that CK1alpha is required for chromosome alignment and segregation during oocyte meiotic maturation and early embryo development

  6. Silencing or deleting the p53 (show TP53 Proteins) gene demonstrated that genotoxic stress elicited Wnt (show WNT2 Proteins) signaling in a p53 (show TP53 Proteins)-independent manner. Instead, this response occurred through reduced abundance of Csnk1a1 (CK1alpha), a kinase that inhibits beta-catenin (show CTNNB1 Proteins).

  7. maintenance of intestinal homeostasis in CKIalpha-deficient gut (show GUSB Proteins) requires p53 (show TP53 Proteins)-mediated growth control, because the combined ablation of Csnk1a1 and either p53 (show TP53 Proteins) or its target gene p21 triggered high-grade dysplasia with extensive proliferation

  8. Casein kinase I (show CSNK1D Proteins) and casein kinase II (show CSNK2A1 Proteins) differentially regulate axin (show AXIN1 Proteins) function

  9. CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C (show HNRNPC PLURAL_@39359@)

  10. CK1 (show KRT1 Proteins) regulates fast synaptic transmission by glutamate (show GRIN1 Proteins) in brain. Activation of CK1 (show KRT1 Proteins) decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 (show PPP1CB Proteins) &/or 2A & increased dephosphorylation of NMDA receptors.

Zebrafish Casein Kinase 1, alpha 1 (CSNK1A1) interaction partners

  1. Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome.

  2. The phosphorylation of p53 (show TP53 Proteins) by CK1 is an isoform-specific reaction to the K(221)RQK(224) loop.

  3. data provide a molecular insight into the structural features that underlie the site specificity of CK1a

Cow (Bovine) Casein Kinase 1, alpha 1 (CSNK1A1) interaction partners

CSNK1A1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Alternative names and synonyms associated with CSNK1A1

  • Casein kinase Ialpha (CkIalpha)
  • casein kinase 1, alpha 1 (CSNK1A1)
  • casein kinase 1, alpha 1 (Csnk1a1)
  • casein kinase 1, alpha 1 (csnk1a1)
  • keratin 1 (KRT1)
  • 2610208K14Rik protein
  • 4632404G05Rik protein
  • 5430427P18Rik protein
  • anon-WO03040301.93 protein
  • anon-WO03040301.95 protein
  • CG2028 protein
  • CHUNP6894 protein
  • CK-II protein
  • ck1 protein
  • ck1a protein
  • ck1alpha protein
  • CKI protein
  • CK I protein
  • CkIa protein
  • CKIALPHA protein
  • CKI alpha protein
  • Csnk1a protein
  • CSNK2A1 protein
  • dmCK1 protein
  • dmckI protein
  • Dmel\\CG2028 protein
  • EHK protein
  • EHK1 protein
  • EPPK protein
  • HLCDGP1 protein
  • K1 protein
  • KER1 protein
  • KRT1A protein
  • l(1)G0492 protein
  • NEPPK protein
  • PKA-C protein
  • PRO2975 protein
  • wu:fb65a02 protein
  • wu:fi30h04 protein
  • wu:fj19c11 protein
  • zgc:92158 protein

Protein level used designations for CSNK1A1

CG2028-PA , CG2028-PB , CG2028-PC , CG2028-PD , CkIalpha-PA , CkIalpha-PB , CkIalpha-PC , CkIalpha-PD , caesin kinase I alpha , casein kinase 1 , casein kinase 1a , casein kinase 1alpha , casein kinase I , casein kinase ialpha , CKI-alpha , casein kinase I isoform alpha , clock regulator kinase , down-regulated in lung cancer , CK1 , casein kinase I-alpha , casein kinase I alpha LS , CK II alpha , casein kinase 2, alpha subunit , casein kinase II subunit alpha , casein kinase 1 alpha , protein kinase CK1 (casein kinase 1) isoform alpha , 67 kDa cytokeratin , CK-1 , cytokeratin 1 , cytokeratin-1 , epidermolytic hyperkeratosis 1 , hair alpha protein , keratin, type II cytoskeletal 1 , type-II keratin Kb1 , K1 , epithelial keratin 1 , epithelial keratin-1 , keratin 1 (epidermolytic hyperkeratosis) , keratin-1

32221 Drosophila melanogaster
1452 Homo sapiens
93687 Mus musculus
113927 Rattus norvegicus
192307 Danio rerio
380238 Xenopus laevis
395924 Gallus gallus
282684 Bos taurus
100514516 Sus scrofa
100301533 Oryctolagus cuniculus
101120241 Ovis aries
100009227 Oryctolagus cuniculus
379624 Xenopus laevis
3848 Homo sapiens
444857 Canis lupus familiaris
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