CSNK1A1 Protein (GST tag)

Catalog No. ABIN7317097

Product Details

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This CSNK1A1 protein is labelled with GST tag.

Purpose: Recombinant Human CSNK1A1/CKI-alpha/CK1 Protein (GST Tag)(Active)

Sequence: Met 1-Phe 337

Characteristics: A DNA sequence encoding the full length of human CSNK1A1 isoform 1 (P48729-1) (Met 1-Phe 337) was expressed with the GST tag at the N-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 30 nmol/min/mg using casein as substrate.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, pH 7.4

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Alternative Name: CSNK1A1/CKI-alpha/CK1 (CSNK1A1 Products)

Synonyms: CK1 Protein, CK1a Protein, CKIa Protein, HLCDGP1 Protein, PRO2975 Protein, 2610208K14Rik Protein, 4632404G05Rik Protein, 5430427P18Rik Protein, Csnk1a Protein, CHUNP6894 Protein, ck1alpha Protein, wu:fb65a02 Protein, wu:fi30h04 Protein, wu:fj19c11 Protein, zgc:92158 Protein, KER1 Protein, ck1 Protein, CKIALPHA Protein, CK-II Protein, CSNK2A1 Protein, CG2028 Protein, CK I Protein, CK1alpha Protein, CKI Protein, CKI alpha Protein, CKIalpha Protein, CkIa Protein, Dmel\\CG2028 Protein, PKA-C Protein, anon-WO03040301.93 Protein, anon-WO03040301.95 Protein, ck1a Protein, dmCK1 Protein, dmckI Protein, l(1)G0492 Protein, casein kinase 1 alpha 1 Protein, casein kinase 1, alpha 1 Protein, keratin 1 Protein, casein kinase 1 alpha 1 L homeolog Protein, casein kinase 2 alpha 1 Protein, Casein kinase Ialpha Protein, CSNK1A1 Protein, Csnk1a1 Protein, csnk1a1 Protein, KRT1 Protein, csnk1a1.L Protein, CSNK2A1 Protein, CkIalpha Protein

Background:

Background: Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis.

Synonym: CK1;CK1a;CKIa;HEL-S-77p;HLCDGP1;PRO2975

Molecular Weight: 65.2 kDa

Pathways: WNT Signaling, Hedgehog Signaling