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LRP6 (show LRP6 Proteins) ectodomain becomes highly compact upon complexation with the Wnt (show WNT2 Proteins) antagonist Dkk1, suggesting a potential role for the ectodomain conformational change in the regulation of receptor oligomerization and signaling.
Our results suggest that measurement of DKK-1 combined with DKK-1 autoantibodies is a potentially valuable tool for the early detection of ESCC.
TET1 (show TET1 Proteins) potently inhibited canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 (show SFRP2 Proteins) and DKK1, which was associated with inhibition of EMT (show ITK Proteins) and cancer cell metastasis.
This is the first study demonstrating a link between B cell depletion and skin Dkk-1 upregulation in patients with systemic sclerosis
We found significantly increased levels of DKK-1 in patients with acute CO poisoning, compared to healthy controls. High levels of serum DKK-1 in patients were significantly correlated with severe neurological symptoms.
DKK1 prevents lung metastasis of breast cancer cells but promotes breast-to-bone metastasis.
Structure of the dual-mode Wnt (show WNT2 Proteins) regulator Kremen1 (show KREMEN1 Proteins) and insight into ternary complex formation with LRP6 (show LRP6 Proteins) and DKK1 have been presented.
CKAP4 (show CKAP4 Proteins) has a role as a Dickkopf1 receptor and in pancreatic and lung tumor progression
Expression of Cancer stem cells-associated DKK1 mRNA might be an unfavorable prognostic marker for patients with hepatocellular carcinoma.
In chronic kidney disease, serum levels of the Wnt (show WNT2 Proteins) inhibitors DKK1 and sclerostin (show SOST Proteins) are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin (show SOST Proteins), as opposed to DKK1, may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD (show DPEP1 Proteins)), particularly in dialysis patients.
The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and Hedgehog (show SHH Proteins) signaling
DKK1 inhibits the WNT (show WNT2 Proteins) signaling pathway and improves pig oocyte maturation.
Association analysis showed that different genotypes of DKK1 were associated with loin muscle area.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (show CHRD Proteins) and subsequent maintenance of dkk1b expression levels.
Kremen1 (show KREMEN1 Proteins) modulates Wnt (show WNT2 Proteins) activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium
Neuromast size is controlled by a balance between growth-promoting Wnt (show WNT2 Proteins) signaling activity in proliferation-competent cells and Wnt (show WNT2 Proteins)-inhibiting Dkk activity produced by differentiated sensory cells.
Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 Proteins) signaling inhibitor, Dkk, and induced expression of the Wnt (show WNT2 Proteins) ligand, Wnt4a.
Membrane-bound DKK-1 is a novel Foxp3 (show FOXP3 Proteins) postive Treg cell derived mediator to maintain immunological tolerance in T-cell-mediated autoimmune colitis.
Dkk1 promotes hematopoietic regeneration via direct effects on hematopoietic stem cells, decreasing the levels of mitochondrial reactive oxygen species and suppressing senescence, and via indirect effects on bone marrow endothelial cells, inducing EGF (show EGF Proteins) secretion.
Recombinant Dkk1 suppresses beta-catenin (show CTNNB1 Proteins) target genes in myeloid-derived suppressor cells (MDSCs) from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin (show CTNNB1 Proteins) in myeloid cells or after depletion of MDSCs, demonstrating that Dkk1 directly targets MDSCs.
A negative feedback loop involving WNT6 (show WNT6 Proteins) and DKK1 attenuates canonical WNT6 (show WNT6 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling, thereby allowing teratocarcinoma cells to differentiate.
Collectively, miR (show MLXIP Proteins)-9 promotes osteoblast differentiation of mesenchymal stem cells by suppressing DKK1 gene expression.
that Dkk1 negatively regulates BMP9 (show GDF2 Proteins)-induced osteogenic differentiation.
Disturbed oscillatory flow increases DKK1 expression. DKK1 knockdown attenuates OSS-induced monocyte adhesion and endothelial impairment. Genetic silencing of DKK1 limits atherogenesis in ApoE (show APOE Proteins)-/- mice.
Dickkopf1 receptor Kremen1 (show KREMEN1 Proteins) is a bona fide dependence receptor, triggering cell death unless bound to its ligand.
These results suggest that inhibiting Wnt (show WNT2 Proteins) signaling in embryonic stem cells using DKK1 may promote mouse ESCs (show NR2E3 Proteins) to differentiate into endoderm in vitro and in vivo
dkk1 preferentially induced the expression of POX2, suggesting that dkk1 works as a morphogen (show SHH Proteins) to determine the different lineages.
N1 is a novel signaling domain within the intact protein that is responsible for the potent effects of Dkk1 on the induction and patterning of the body axis and heart
target Wnts of Dkk activity are maternal Wnt5a (show WNT5A Proteins) and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
dickkopf 1 homolog
, dickkopf related protein-1
, dickkopf-1 like
, dickkopf-like protein 1
, dickkopf-related protein 1
, dickkopf homolog 1
, dickkopf 1
, dickkopf protein