Browse our DKK1 Proteins (DKK1)

Full name:
Dickkopf Homolog 1 (Xenopus Laevis) Proteins (DKK1)
On are 55 Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) Proteins from 16 different suppliers available. Additionally we are shipping DKK1 Antibodies (220) and DKK1 Kits (74) and many more products for this protein. A total of 371 DKK1 products are currently listed.
AI414495, CT34, dickkopf-1, Dickkopf1, dkk, DKK-1, dkk1, dkk1-A, mdkk-1, mSgy, SGY, SGY-1, SGY1, SK, Soggy, Xdkk-1, xdkk1
list all proteins Gene Name GeneID UniProt
DKK1 13380 O54908
DKK1 22943 O94907
DKK1 293897  

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DKK1 Proteins (DKK1) by Origin

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Top referenced DKK1 Proteins

  1. Rhesus Monkey DKK1 Protein expressed in Human Cells - ABIN2003963 : Glinka, Wu, Delius, Monaghan, Blumenstock, Niehrs: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. in Nature 1998 (PubMed)
    Show all 7 references for 2003963

  2. Rhesus Monkey DKK1 Protein expressed in Human Cells - ABIN2003960 : Mao, Wu, Li, Hoppe, Stannek, Glinka, Niehrs: LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. in Nature 2001 (PubMed)
    Show all 7 references for 2003960

  3. Human DKK1 Protein expressed in Hi-5 - ABIN666746 : Nusse: Developmental biology. Making head or tail of Dickkopf. in Nature 2001 (PubMed)
    Show all 3 references for 666746

  4. Human DKK1 Protein expressed in HEK-293 Cells - ABIN2180963 : Li, Pazgier, Li, Li, Liu, Zou, Li, Chen, Tarasov, Lu, Lu: Limitations of peptide retro-inverso isomerization in molecular mimicry. in The Journal of biological chemistry 2010 (PubMed)

  5. Human DKK1 Protein expressed in Human Cells - ABIN2003474 : Kohn, Kaneko, DePamphilis: DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis. in Molecular reproduction and development 2005 (PubMed)

More Proteins for DKK1 Interaction Partners

Pig (Porcine) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. DKK1 inhibits the WNT (show WNT2 Proteins) signaling pathway and improves pig oocyte maturation.

  2. Association analysis showed that different genotypes of DKK1 were associated with loin muscle area.

Rabbit Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and Hedgehog (show SHH Proteins) signaling

Zebrafish Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (show CHRD Proteins) and subsequent maintenance of dkk1b expression levels.

  2. Kremen1 (show KREMEN1 Proteins) modulates Wnt (show WNT2 Proteins) activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium

  3. Neuromast size is controlled by a balance between growth-promoting Wnt (show WNT2 Proteins) signaling activity in proliferation-competent cells and Wnt (show WNT2 Proteins)-inhibiting Dkk activity produced by differentiated sensory cells.

  4. Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins

  5. Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 Proteins) signaling inhibitor, Dkk, and induced expression of the Wnt (show WNT2 Proteins) ligand, Wnt4a.

Mouse (Murine) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. Dkk1 promotes hematopoietic regeneration via direct effects on hematopoietic stem cells, decreasing the levels of mitochondrial reactive oxygen species and suppressing senescence, and via indirect effects on bone marrow endothelial cells, inducing EGF (show EGF Proteins) secretion.

  2. Recombinant Dkk1 suppresses beta-catenin (show CTNNB1 Proteins) target genes in myeloid-derived suppressor cells (MDSCs) from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin (show CTNNB1 Proteins) in myeloid cells or after depletion of MDSCs, demonstrating that Dkk1 directly targets MDSCs.

  3. A negative feedback loop involving WNT6 (show WNT6 Proteins) and DKK1 attenuates canonical WNT6 (show WNT6 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling, thereby allowing teratocarcinoma cells to differentiate.

  4. Collectively, miR (show MLXIP Proteins)-9 promotes osteoblast differentiation of mesenchymal stem cells by suppressing DKK1 gene expression.

  5. that Dkk1 negatively regulates BMP9 (show GDF2 Proteins)-induced osteogenic differentiation.

  6. Disturbed oscillatory flow increases DKK1 expression. DKK1 knockdown attenuates OSS-induced monocyte adhesion and endothelial impairment. Genetic silencing of DKK1 limits atherogenesis in ApoE (show APOE Proteins)-/- mice.

  7. Dickkopf1 receptor Kremen1 (show KREMEN1 Proteins) is a bona fide dependence receptor, triggering cell death unless bound to its ligand.

  8. These results suggest that inhibiting Wnt (show WNT2 Proteins) signaling in embryonic stem cells using DKK1 may promote mouse ESCs (show NR2E3 Proteins) to differentiate into endoderm in vitro and in vivo

  9. These in vivo data support in vitro studies regarding the mechanism of HBM (show LRP5 Proteins)-causing mutations, and imply that HBM LRP5 (show LRP5 Proteins) receptors differ in their relative sensitivity to inhibition by SOST (show SOST Proteins) and DKK1.

  10. The combination of Dkk-1 overexpression by Dex and hypoxia causes the necrotic osteocytic cell death.

Cow (Bovine) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]

Human Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. CKAP4 (show CKAP4 Proteins) has a role as a Dickkopf1 receptor and in pancreatic and lung tumor progression

  2. Expression of Cancer stem cells-associated DKK1 mRNA might be an unfavorable prognostic marker for patients with hepatocellular carcinoma.

  3. In chronic kidney disease, serum levels of the Wnt (show WNT2 Proteins) inhibitors DKK1 and sclerostin (show SOST Proteins) are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin (show SOST Proteins), as opposed to DKK1, may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD (show DPEP1 Proteins)), particularly in dialysis patients.

  4. endogenous expression of the WNT (show WNT2 Proteins) antagonists DKK1 and FRZB (show FRZB Proteins) is necessary for multiple steps during chondrogenesis

  5. The expression level of DKK1 in serum was increased in breast cancer patients, suggesting that serum expression level of DKK1 could be a useful biomarker in breast cancer.

  6. Results show that the expression of DKK1 is elevated in human HBV-related hepatocellular carcinoma tissues.

  7. DKK-1 and PDCD5 (show PDCD5 Proteins) can be independent predictors of overall survival in patients suffering from chondrosarcoma.

  8. In patients with hepatocellular carcinoma serum DKK1 level correlated with tumor size, consequently, patients with bigger tumors tend to have higher levels of DKK1.

  9. Our results indicate that DKK1 and SFRP1 (show SFRP1 Proteins) may be potentially useful biomarkers for evaluating the beneficial effects of long-term exercise on physical fitness and metabolism as well as the prognosis of patients with cancer.

  10. Dickkopf-1 and sclerostin (show SOST Proteins) were never correlated with each other or with bone turnover markers patients with Paget's disease of bone

Xenopus laevis Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. dkk1 preferentially induced the expression of POX2, suggesting that dkk1 works as a morphogen (show SHH Proteins) to determine the different lineages.

  2. N1 is a novel signaling domain within the intact protein that is responsible for the potent effects of Dkk1 on the induction and patterning of the body axis and heart

  3. target Wnts of Dkk activity are maternal Wnt5a (show WNT5A Proteins) and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling

DKK1 Protein Profile

Protein Summary

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with DKK1

  • dickkopf 1 homolog (Xenopus laevis) (DKK1)
  • dickkopf WNT signaling pathway inhibitor 1 (dkk1)
  • dickkopf protein (dickkopf)
  • dickkopf 1b (dkk1b)
  • dickkopf homolog 1 (Xenopus laevis) (Dkk1)
  • dickkopf homolog 1 (Xenopus laevis) (DKK1)
  • dickkopf WNT signaling pathway inhibitor 1 (DKK1)
  • dickkopf WNT signaling pathway inhibitor 1 (Dkk1)
  • dickkopf-like 1 (DKKL1)
  • dickkopf-like 1 (Dkkl1)
  • AI414495 protein
  • CT34 protein
  • dickkopf-1 protein
  • Dickkopf1 protein
  • dkk protein
  • DKK-1 protein
  • dkk1 protein
  • dkk1-A protein
  • mdkk-1 protein
  • mSgy protein
  • SGY protein
  • SGY-1 protein
  • SGY1 protein
  • SK protein
  • Soggy protein
  • Xdkk-1 protein
  • xdkk1 protein

Protein level used designations for DKK1

dickkopf homolog 1 , dickkopf-like protein 1 , dickkopf-related protein 1 , dickkopf 1 homolog , dickkopf protein , Ci-dickkopf , dickkopf1 , dickkopf 1 , dickkopf-1 , dkk-1 , dickkopf related protein-1 , dickkopf-1 like , hDkk-1 , cancer/testis antigen 34 , protein soggy-1 , soggy , soggy-1 , soggy 1

450465 Pan troglodytes
702997 Macaca mulatta
100228789 Taeniopygia guttata
549037 Xenopus (Silurana) tropicalis
778575 Ciona intestinalis
780707 Ciona intestinalis
609600 Canis lupus familiaris
100157640 Sus scrofa
100009504 Oryctolagus cuniculus
101116876 Ovis aries
30197 Danio rerio
13380 Mus musculus
374156 Gallus gallus
504445 Bos taurus
22943 Homo sapiens
373592 Xenopus laevis
293897 Rattus norvegicus
100731485 Cavia porcellus
27120 Homo sapiens
50722 Mus musculus
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