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Browse our DKK1 Proteins (DKK1)

Full name:
Dickkopf Homolog 1 (Xenopus Laevis) Proteins (DKK1)
On are 52 Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) Proteins from 16 different suppliers available. Additionally we are shipping DKK1 Antibodies (212) and DKK1 Kits (74) and many more products for this protein. A total of 360 DKK1 products are currently listed.
AI414495, CT34, dickkopf-1, Dickkopf1, dkk, DKK-1, dkk1, dkk1-A, mdkk-1, mSgy, SGY, SGY-1, SGY1, SK, Soggy, Xdkk-1, xdkk1
list all proteins Gene Name GeneID UniProt
DKK1 13380 O54908
DKK1 22943 O94907
DKK1 293897  

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DKK1 Proteins (DKK1) by Origin

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Top referenced DKK1 Proteins

  1. Rhesus Monkey DKK1 Protein expressed in Human Cells - ABIN2003963 : Glinka, Wu, Delius, Monaghan, Blumenstock, Niehrs: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. in Nature 1998 (PubMed)
    Show all 7 references for ABIN2003963

  2. Rhesus Monkey DKK1 Protein expressed in Human Cells - ABIN2003960 : Mao, Wu, Li, Hoppe, Stannek, Glinka, Niehrs: LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. in Nature 2001 (PubMed)
    Show all 7 references for ABIN2003960

  3. Human DKK1 Protein expressed in Hi-5 - ABIN666746 : Nusse: Developmental biology. Making head or tail of Dickkopf. in Nature 2001 (PubMed)
    Show all 3 references for ABIN666746

  4. Human DKK1 Protein expressed in HEK-293 Cells - ABIN2180963 : Li, Pazgier, Li, Li, Liu, Zou, Li, Chen, Tarasov, Lu, Lu: Limitations of peptide retro-inverso isomerization in molecular mimicry. in The Journal of biological chemistry 2010 (PubMed)

  5. Human DKK1 Protein expressed in Human Cells - ABIN2003474 : Kohn, Kaneko, DePamphilis: DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis. in Molecular reproduction and development 2005 (PubMed)

More Proteins for DKK1 Interaction Partners

Pig (Porcine) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. DKK1 inhibits the WNT (show WNT2 Proteins) signaling pathway and improves pig oocyte maturation.

  2. Association analysis showed that different genotypes of DKK1 were associated with loin muscle area.

Rabbit Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and Hedgehog (show SHH Proteins) signaling

Zebrafish Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (show CHRD Proteins) and subsequent maintenance of dkk1b expression levels.

  2. Kremen1 (show KREMEN1 Proteins) modulates Wnt (show WNT2 Proteins) activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium

  3. Neuromast size is controlled by a balance between growth-promoting Wnt (show WNT2 Proteins) signaling activity in proliferation-competent cells and Wnt (show WNT2 Proteins)-inhibiting Dkk activity produced by differentiated sensory cells.

  4. Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins

  5. Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 Proteins) signaling inhibitor, Dkk, and induced expression of the Wnt (show WNT2 Proteins) ligand, Wnt4a.

Mouse (Murine) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. A negative feedback loop involving WNT6 (show WNT6 Proteins) and DKK1 attenuates canonical WNT6 (show WNT6 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling, thereby allowing teratocarcinoma cells to differentiate.

  2. Collectively, miR (show MLXIP Proteins)-9 promotes osteoblast differentiation of mesenchymal stem cells by suppressing DKK1 gene expression.

  3. that Dkk1 negatively regulates BMP9 (show GDF2 Proteins)-induced osteogenic differentiation.

  4. Disturbed oscillatory flow increases DKK1 expression. DKK1 knockdown attenuates OSS-induced monocyte adhesion and endothelial impairment. Genetic silencing of DKK1 limits atherogenesis in ApoE (show APOE Proteins)-/- mice.

  5. Dickkopf1 receptor Kremen1 (show KREMEN1 Proteins) is a bona fide dependence receptor, triggering cell death unless bound to its ligand.

  6. These results suggest that inhibiting Wnt (show WNT2 Proteins) signaling in embryonic stem cells using DKK1 may promote mouse ESCs (show NR2E3 Proteins) to differentiate into endoderm in vitro and in vivo

  7. These in vivo data support in vitro studies regarding the mechanism of HBM (show LRP5 Proteins)-causing mutations, and imply that HBM LRP5 (show LRP5 Proteins) receptors differ in their relative sensitivity to inhibition by SOST (show SOST Proteins) and DKK1.

  8. The combination of Dkk-1 overexpression by Dex and hypoxia causes the necrotic osteocytic cell death.

  9. platelet-derived Dickkopf-1 (Dkk1) as the major Wnt (show WNT2 Proteins) antagonist contributing to the suppression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in AECs during acute lung inflammation.

  10. R-spondin 1 (show RSPO1 Proteins)/dickkopf-1/beta-catenin (show CTNNB1 Proteins) machinery is involved in testicular embryonic angiogenesis

Cow (Bovine) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]

Human Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. Circulating sclerostin and Dickkopf-1 levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women.

  2. Results found miR (show MLXIP Proteins)-203 and DKK1 to be expressed at differential levels in cisplatin-sensitive and -insensitive lung adenocarcinoma tissues; there was also a negative correlation between them.

  3. Serum levels of OPG (show TNFRSF11B Proteins) and DKK-1 were measured in 97 rheumatoid arthritis patients who were treated according to a treat-to-target strategy (T2T) aimed at remission (DAS28<2.6).

  4. DKK1 can promote vasculogenic mimicry formation via induction of the expression of epithelial-mesenchymal transition and cancer stem-like cell-related proteins.

  5. Our study highlighted the high serum levels of DKK-1 and sclerostin (show SOST Proteins) in T1DM children and their relationship with altered glycemic control

  6. DKK-1 may play a role in switching to new bone formation in ankylosing spondylitis progression.

  7. link between Fibulin-4 (show FBLN4 Proteins) and the canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway that may contribute to our understanding of the molecular mechanisms of OA

  8. our findings reveal a new regulatory mechanism for miR (show MLXIP Proteins)-373-3p and suggest that miR (show MLXIP Proteins)-373-3p might be a potential target in tongue squamous cell carcinoma therapy

  9. there is a SP1 (show PSG1 Proteins) site in DKK1 promoter region; overexpression of SP1 (show PSG1 Proteins) could increase DKK1 promoter activity in a dose dependent manner; and siRNA inhibition of SP1 (show PSG1 Proteins) expression reduced DKK1 promoter activity and decreased the expression of DKK1 protein.

  10. After evaluating a panel of Wnt (show WNT2 Proteins) activating and inhibiting molecules, authors show that primary human MSCs increase the expression of Dkk-1, an inhibitor of Wnt (show WNT2 Proteins) signaling, into the extracellular environment following chemotherapy exposure in a p53 (show TP53 Proteins)-dependent manner.

Xenopus laevis Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. dkk1 preferentially induced the expression of POX2, suggesting that dkk1 works as a morphogen (show SHH Proteins) to determine the different lineages.

  2. N1 is a novel signaling domain within the intact protein that is responsible for the potent effects of Dkk1 on the induction and patterning of the body axis and heart

  3. target Wnts of Dkk activity are maternal Wnt5a (show WNT5A Proteins) and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling

DKK1 Protein Profile

Protein Summary

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with DKK1

  • dickkopf 1 homolog (Xenopus laevis) (DKK1)
  • dickkopf WNT signaling pathway inhibitor 1 (dkk1)
  • dickkopf protein (dickkopf)
  • dickkopf 1b (dkk1b)
  • dickkopf homolog 1 (Xenopus laevis) (Dkk1)
  • dickkopf homolog 1 (Xenopus laevis) (DKK1)
  • dickkopf WNT signaling pathway inhibitor 1 (DKK1)
  • dickkopf WNT signaling pathway inhibitor 1 (Dkk1)
  • dickkopf-like 1 (DKKL1)
  • dickkopf-like 1 (Dkkl1)
  • AI414495 protein
  • CT34 protein
  • dickkopf-1 protein
  • Dickkopf1 protein
  • dkk protein
  • DKK-1 protein
  • dkk1 protein
  • dkk1-A protein
  • mdkk-1 protein
  • mSgy protein
  • SGY protein
  • SGY-1 protein
  • SGY1 protein
  • SK protein
  • Soggy protein
  • Xdkk-1 protein
  • xdkk1 protein

Protein level used designations for DKK1

dickkopf homolog 1 , dickkopf-like protein 1 , dickkopf-related protein 1 , dickkopf 1 homolog , dickkopf protein , Ci-dickkopf , dickkopf1 , dickkopf 1 , dickkopf-1 , dkk-1 , dickkopf related protein-1 , dickkopf-1 like , hDkk-1 , cancer/testis antigen 34 , protein soggy-1 , soggy , soggy-1 , soggy 1

450465 Pan troglodytes
702997 Macaca mulatta
100228789 Taeniopygia guttata
549037 Xenopus (Silurana) tropicalis
778575 Ciona intestinalis
780707 Ciona intestinalis
609600 Canis lupus familiaris
100157640 Sus scrofa
100009504 Oryctolagus cuniculus
101116876 Ovis aries
30197 Danio rerio
13380 Mus musculus
374156 Gallus gallus
504445 Bos taurus
22943 Homo sapiens
373592 Xenopus laevis
293897 Rattus norvegicus
100731485 Cavia porcellus
27120 Homo sapiens
50722 Mus musculus
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