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Browse our DKK1 Proteins (DKK1)

Full name:
Dickkopf Homolog 1 (Xenopus Laevis) Proteins (DKK1)
On are 49 Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) Proteins from 16 different suppliers available. Additionally we are shipping DKK1 Antibodies (204) and DKK1 Kits (70) and many more products for this protein. A total of 345 DKK1 products are currently listed.
AI414495, CT34, dickkopf-1, Dickkopf1, dkk, DKK-1, dkk1, dkk1-A, mdkk-1, mSgy, SGY, SGY-1, SGY1, SK, Soggy, Xdkk-1, xdkk1
list all proteins Gene Name GeneID UniProt
DKK1 13380 O54908
DKK1 22943 O94907
DKK1 293897  

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DKK1 Proteins (DKK1) by Origin

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Top referenced DKK1 Proteins

  1. Rhesus Monkey DKK1 Protein expressed in Human Cells - ABIN2003963 : Glinka, Wu, Delius, Monaghan, Blumenstock, Niehrs: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. in Nature 1998 (PubMed)
    Show all 7 references for ABIN2003963

  2. Human DKK1 Protein expressed in Hi-5 - ABIN666746 : Nusse: Developmental biology. Making head or tail of Dickkopf. in Nature 2001 (PubMed)
    Show all 3 references for ABIN666746

  3. Human DKK1 Protein expressed in HEK-293 Cells - ABIN2180963 : Li, Pazgier, Li, Li, Liu, Zou, Li, Chen, Tarasov, Lu, Lu: Limitations of peptide retro-inverso isomerization in molecular mimicry. in The Journal of biological chemistry 2010 (PubMed)

  4. Human DKK1 Protein expressed in Human Cells - ABIN2003474 : Kohn, Kaneko, DePamphilis: DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis. in Molecular reproduction and development 2005 (PubMed)

More Proteins for DKK1 Interaction Partners

Pig (Porcine) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. DKK1 inhibits the WNT (show WNT2 Proteins) signaling pathway and improves pig oocyte maturation.

  2. Association analysis showed that different genotypes of DKK1 were associated with loin muscle area.

Zebrafish Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. Kremen1 (show KREMEN1 Proteins) modulates Wnt (show WNT2 Proteins) activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium

  2. Neuromast size is controlled by a balance between growth-promoting Wnt (show WNT2 Proteins) signaling activity in proliferation-competent cells and Wnt (show WNT2 Proteins)-inhibiting Dkk activity produced by differentiated sensory cells.

  3. Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins

  4. Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 Proteins) signaling inhibitor, Dkk, and induced expression of the Wnt (show WNT2 Proteins) ligand, Wnt4a.

Mouse (Murine) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. Dickkopf1 receptor Kremen1 (show KREMEN1 Proteins) is a bona fide dependence receptor, triggering cell death unless bound to its ligand.

  2. These results suggest that inhibiting Wnt (show WNT2 Proteins) signaling in embryonic stem cells using DKK1 may promote mouse ESCs (show NR2E3 Proteins) to differentiate into endoderm in vitro and in vivo

  3. These in vivo data support in vitro studies regarding the mechanism of HBM (show LRP5 Proteins)-causing mutations, and imply that HBM LRP5 (show LRP5 Proteins) receptors differ in their relative sensitivity to inhibition by SOST (show SOST Proteins) and DKK1.

  4. The combination of Dkk-1 overexpression by Dex and hypoxia causes the necrotic osteocytic cell death.

  5. platelet-derived Dickkopf-1 (Dkk1) as the major Wnt (show WNT2 Proteins) antagonist contributing to the suppression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in AECs during acute lung inflammation.

  6. R-spondin 1 (show RSPO1 Proteins)/dickkopf-1/beta-catenin (show CTNNB1 Proteins) machinery is involved in testicular embryonic angiogenesis

  7. When Dkk1(+/-) mice were crossed with Bmp2 (show BMP2 Proteins)(c/c);Prx1 (show PRDX1 Proteins)::cre mice, the offspring bearing both genetic alterations were unable to increase bone mass and heal fractures

  8. thyroid hormone (show PTH Proteins)-induced changes in bone remodeling are associated with a divergent regulation of DKK1 and sclerostin (show SOST Proteins)

  9. OTX2 (show OTX2 Proteins) and DKK1 exhibit asymmetric expression in the anterior ventral endoderm during embryonic anterior-posterior axis formation.

  10. Data indicate that both Dickkopf-1 (DKK1) and sclerostin (SOST (show SOST Proteins)) were downregulated in proteoglycan (show Vcan Proteins)-induced spondylitis (PGISp)-affected mouse spines.

Cow (Bovine) Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]

Human Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. High serum DKK-1 levels may be associated with tumor progression and poor prognosis in bladder cancer and may be used as a potential biomarker to predict the prognosis of patients with bladder cancer

  2. miR (show MLXIP Proteins)-152 blocked DKK1 transcriptional activity by binding to the 3'UTR of DKK1 mRNA.

  3. Synovial fibroblasts from patients with very early rheumatoid arthritis expressed significantly higher levels of DKK1 compared to patients with resolving arthritis.

  4. DKK1 polymorphisms may correlate to baseline bone mineral density and serum beta-CTX (show CYP27A1 Proteins) levels, but present a weak effect on the response to alendronate.

  5. Through expression of the WNT (show WNT2 Proteins) inhibitor DKK1, latency competent cancer cells self-impose a slow-cycling state with broad downregulation of ULBP ligands for NK cells and evasion of NK-cell-mediated clearance.

  6. DKK1 is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1's effects in inhibiting migration and invasion of breast cancer cells.

  7. DKK1 is associated with angiogenesis in the synovial fluid of patients with temporomandibular joint disorders

  8. AFP (show AFP Proteins) remained the best single marker, and the combined use of AFP (show AFP Proteins) with prothrombin (show F2 Proteins) precursor or DKK-1 had the best diagnostic performance compared to all other possible combinations of the four biomarkers, even in early stage hepatocellular carcinoma.

  9. Data indicate that in rheumatoid arthritis patients, level of receptor activator of nuclear factor-kappaB ligand (RANKL (show TNFSF11 Proteins)) on T cells is elevated, and the serum level of RANKL (show TNFSF11 Proteins) increases, but Dickkopf1 protein (DKK1) decreases.

  10. SOST (show SOST Proteins) and DKK1 have opposing effects on PC3 (show PCSK1 Proteins) cell invasion and bone-derived Wnt (show WNT2 Proteins) signaling positively contributes to the invasive phenotypes of PC3 (show PCSK1 Proteins)

Xenopus laevis Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) interaction partners

  1. dkk1 preferentially induced the expression of POX2, suggesting that dkk1 works as a morphogen (show SHH Proteins) to determine the different lineages.

  2. N1 is a novel signaling domain within the intact protein that is responsible for the potent effects of Dkk1 on the induction and patterning of the body axis and heart

  3. target Wnts of Dkk activity are maternal Wnt5a (show WNT5A Proteins) and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling

DKK1 Protein Profile

Protein Summary

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with DKK1

  • dickkopf 1 homolog (Xenopus laevis) (DKK1)
  • dickkopf WNT signaling pathway inhibitor 1 (dkk1)
  • dickkopf protein (dickkopf)
  • dickkopf 1b (dkk1b)
  • dickkopf homolog 1 (Xenopus laevis) (Dkk1)
  • dickkopf homolog 1 (Xenopus laevis) (DKK1)
  • dickkopf WNT signaling pathway inhibitor 1 (DKK1)
  • dickkopf WNT signaling pathway inhibitor 1 (Dkk1)
  • dickkopf-like 1 (DKKL1)
  • dickkopf-like 1 (Dkkl1)
  • AI414495 protein
  • CT34 protein
  • dickkopf-1 protein
  • Dickkopf1 protein
  • dkk protein
  • DKK-1 protein
  • dkk1 protein
  • dkk1-A protein
  • mdkk-1 protein
  • mSgy protein
  • SGY protein
  • SGY-1 protein
  • SGY1 protein
  • SK protein
  • Soggy protein
  • Xdkk-1 protein
  • xdkk1 protein

Protein level used designations for DKK1

dickkopf homolog 1 , dickkopf-like protein 1 , dickkopf-related protein 1 , dickkopf 1 homolog , dickkopf protein , Ci-dickkopf , dickkopf1 , dickkopf 1 , dickkopf-1 , dkk-1 , dickkopf related protein-1 , dickkopf-1 like , hDkk-1 , cancer/testis antigen 34 , protein soggy-1 , soggy , soggy-1 , soggy 1

450465 Pan troglodytes
702997 Macaca mulatta
100228789 Taeniopygia guttata
549037 Xenopus (Silurana) tropicalis
778575 Ciona intestinalis
780707 Ciona intestinalis
609600 Canis lupus familiaris
100157640 Sus scrofa
100009504 Oryctolagus cuniculus
101116876 Ovis aries
30197 Danio rerio
13380 Mus musculus
374156 Gallus gallus
504445 Bos taurus
22943 Homo sapiens
373592 Xenopus laevis
293897 Rattus norvegicus
100731485 Cavia porcellus
27120 Homo sapiens
50722 Mus musculus
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